4-Methyl-malachitgruen | 17717-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methyl-malachitgruen
• 英文别名: [4-[[4-(Dimethylamino)phenyl]-(4-methylphenyl)methylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium
• CAS: 17717-39-4
• 化学式: C₂₄H₂₇N₂
• 分子量: 343.492
• InChiKey: NKVMQUJYFIVECI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  6.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Methyl-malachitgruen 在 三氧化硫 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Sinev, V. V.; Ivanov, Yu. E., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 10, p. 1866 - 1870

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲苯基溴化镁 、 米氏酮 生成 4-Methyl-malachitgruen
  参考文献：
  名称：

  Ginsburg; Sawlin, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 678,680; engl. Ausg. S. 747, 749

  摘要：

  DOI：

文献信息

• Sinev, V. V.; Nikolova, T. A., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 707 - 713
  作者：Sinev, V. V.、Nikolova, T. A.

  DOI：——

  日期：——
• Sinev, V. V.; Smirnova, E. N., Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 1070 - 1072
  作者：Sinev, V. V.、Smirnova, E. N.

  DOI：——

  日期：——
• Methods of discovering chemicals capable of functioning as gene expression modulators
  申请人：Foulkes Gordon J.

  公开号：US20080009060A1

  公开（公告）日：2008-01-10

  The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell. Additionally, this invention provides a method for determining whether a molecule known to be a modulator of protein biosynthesis is capable of transcriptionally modulating expression of a gene-of-interest.
• Ginsburg; Sawlin, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 678,680; engl. Ausg. S. 747, 749
  作者：Ginsburg、Sawlin

  DOI：——

  日期：——
• Sinev, V. V.; Ivanov, Yu. E., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 10, p. 1866 - 1870
  作者：Sinev, V. V.、Ivanov, Yu. E.

  DOI：——

  日期：——