2-(4-propylphenyl)ethanol | 107473-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-propylphenyl)ethanol
• 英文别名: 4-propyl-phenethyl alcohol；2-Hydroxy-1-(4-propyl-phenyl)-aethan；1-(4-Propyl-phenyl)-aethanol-(2)；4-Propyl-phenaethylalkohol
• CAS: 107473-34-7
• 化学式: C₁₁H₁₆O
• 分子量: 164.247
• InChiKey: COXVVRAGVZOPFK-UHFFFAOYSA-N

物化性质

• 沸点：
  97-98 °C(Press: 1 Torr)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-propylphenyl)ethanol 在 三溴化磷 作用下， 以 二氯甲烷 为溶剂， 以33 %的产率得到C₁₁H₁₅Br
  参考文献：
  名称：

  AROMATIC COMPOUND, ORGANIC SEMICONDUCTOR LAYER AND ORGANIC THIN FILM TRANSISTOR

  摘要：

  An aromatic compound which is represented by formula (1-I) or (1 -II). In formulae (1-I) and (1-II), Ar represents a monocyclic ring or the like; each of X 1 and X 2 represents an oxygen atom or the like; each of Y 1 and Y 2 represents CR 6 or the like; each of R 1 to R 6 represents a hydrogen atom or the like; and at least one of the R 1 to R 6 moieties is a group that is represented by formula (2). In formula (2), A represents a specific alkenyl group or the like; each of 1 and n represents 0 or 1; m represents an integer from 1 to 20; and each of Z 1 and Z 2 represents a hydrogen atom or the like.

  公开号：

  US20230142592A1
• 作为产物：
  描述：

  4-丙基苯乙酸 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-(4-propylphenyl)ethanol
  参考文献：
  名称：

  Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding

  摘要：

  DOI：

  10.1021/acs.jmedchem.3c01189

文献信息

• Improved Synthesis of 2-(4-Propylphenyl)ethanol
  作者：A. Stephen K. Hashmi、Tobias Burkert、Jan W. Bats、Aleksandra Martyniak

  DOI：10.1515/znb-2006-0210

  日期：2006.2.1

  A new procedure for the synthesis of 2-(4-propylphenyl)ethanol is provided. This new procedure significantly reduces side-products as 1-(4-propylphenyl)ethanol and 2-bromoethanol, which are obtained when using the previously known procedure. Only with the new procedure an efficient purification on the large scale needed for avoided-level-crossing muon-spin resonance experiments was possible.

  Structural details of the title compound could be derived from an X-ray structure analysis of a crystalline derivative, the nitrobenzoyl ester.

  摘要 提供了一种合成2-(4-丙基苯基)乙醇的新方法。使用这种新方法可以显著减少副产物，如1-(4-丙基苯基)乙醇和2-溴乙醇，而这些副产物是使用先前已知的方法时所得到的。只有使用这种新方法才能进行大规模高效的纯化，以进行避免电平交叉的缪子自旋共振实验。 通过对结晶衍生物——硝基苯甲酰酯的X射线结构分析，可以得到该标题化合物的结构细节。
• Cis-1,4-substituted 2-butene derivative
  申请人：Chisso Corporation

  公开号：US05401434A1

  公开（公告）日：1995-03-28

  A novel liquid crystal compound having an intermediate group of a cis-1,4-substituted 2-butenyl group, low viscosity and a broad mesomorphic temperature range is provided, which compound is expressed by the following formula: ##STR1## wherein R.sup.1 represents an alkyl group of 1 to 10 carbon atoms, n represents 1 or 2, X represents a hydrogen atom, an alkyl group, a halogen atom, a cyano group, an alkoxy group, a methyl group substituted by 1 to 3 halogen atom(s) or a trihaloalkoxy group, and Y and Y' each independently represents a hydrogen atom, or a halogen atom.

  提供了一种新型液晶化合物，具有一个顺式-1,4-取代的2-丁烯基中间基团，低粘度和宽广的介温范围，该化合物由以下公式表示：##STR1## 其中R.sup.1表示1至10个碳原子的烷基，n表示1或2，X表示氢原子、烷基、卤素原子、氰基、烷氧基、1至3个卤素原子取代的甲基基团或三卤代烷氧基，Y和Y'各自独立表示氢原子或卤素原子。
• AZOLE AND THIAZOLE DERIVATIVES AND THEIR USE
  申请人：Ray Nicholas Charles

  公开号：US20120277275A1

  公开（公告）日：2012-11-01

  Compounds of formula (I) are useful in the treatment of diseases where enhanced M3 receptor activation is implicated, such as respiratory tract diseases:

  式(I)的化合物在治疗呼吸道疾病等需要增强M3受体激活的疾病中很有用。
• BENZAMIDE DERIVATIVES AND THEIR USE AS HSP90 INHIBTORS
  申请人：Donald Alastair David Graham

  公开号：US20130143926A1

  公开（公告）日：2013-06-06

  The invention provides a compound which is (a) a phenylamide derivative of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt, N-oxide, hydrate, prodrug or solvate thereof: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. The compounds are useful in the treatment of diseases mediated by HSP90.

  该发明提供了一种化合物，它是（a）公式（I）的苯酰胺衍生物或其互变异构体，或（b）其药学上可接受的盐，N-氧化物，水合物，前药或溶剂化物：其中R1，R2，R3，R4，R5，R6和R7如本文所定义。这些化合物在治疗由HSP90介导的疾病方面是有用的。
• ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
  申请人：SANOFI

  公开号：US20140309264A1

  公开（公告）日：2014-10-16

  The present invention relates to compounds of the formula I, wherein A, Y, Z, R 3 to R 6 , R 20 to R 22 and R 50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA 1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

  本发明涉及公式I的化合物，其中A、Y、Z、R3至R6、R20至R22和R50具有所述权利要求中指示的含义，它们是有价值的药物活性化合物。具体而言，它们是内皮分化基因受体2（Edg-2，EDG2）的抑制剂，该受体被溶血磷脂酸（LPA）激活，也称为LPA1受体，并且对于例如动脉粥样硬化、心肌梗死和心力衰竭等疾病的治疗是有用的。此外，本发明还涉及公式I化合物的制备方法、它们的使用以及包含它们的药物组合物。