benzyl N-[2-(2-aminoethylamino)ethyl] carbamate | 135646-62-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl N-[2-(2-aminoethylamino)ethyl] carbamate
• 英文别名: benzyl N-[2-(2-aminoethylamino)ethyl]carbamate
• CAS: 135646-62-7
• 化学式: C₁₂H₁₉N₃O₂
• 分子量: 237.302
• InChiKey: DZFDRXLZVDLWJK-UHFFFAOYSA-N

物化性质

• 沸点：
  421.2±35.0 °C(Predicted)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  76.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzyl N-[2-(2-aminoethylamino)ethyl] carbamate 在 sodium tetrahydroborate 作用下， 以 甲醇 、 氯仿 为溶剂， 生成 benzyl N-[2-[2-[[2-methoxy-3-[[2-[2-(phenylmethoxycarbonylamino)ethylamino]ethylamino]methyl]phenyl]methylamino]ethylamino]ethyl]carbamate
  参考文献：
  名称：

  含1,1'-双（2-苯酚）功能的多胺大环的模板合成

  摘要：

  报道了两个新的多胺大环的合成，每个大环带有1,1'-双（2-苯酚）基团作为环状骨架的组成部分。通过使用合适的多胺的镉（II）配合物与3,3'-二甲酰基-1,1'-双（2-苯酚）缩合的模板反应获得配体，然后选择性还原两个亚胺键并脱金属在酸性介质中。

  DOI：

  10.1002/1099-0690(20022)2002:3<402::aid-ejoc402>3.0.co;2-e
• 作为产物：
  描述：

  氯甲酸苄酯 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 氯仿 为溶剂， 生成 benzyl N-[2-(2-aminoethylamino)ethyl] carbamate
  参考文献：
  名称：

  Modification of the enkephalin "message" with an artificial polycationic C-terminus

  摘要：

  The C-terminal ''address'' sequences of prodynorphin-drived opioid peptides contain an unusually high proportion of basic residues, which are known to be crucial for conferring high activity and selectivity for kappa-opioid receptors. In an effort to investigate the possibility that the polycationic ''tails'' may be involved in a coulombic interaction with a complementary polyanionic receptor domain, we attached a series of achiral peptide-like cationic fragments to the C-terminus of the opioid peptide ''message'', Tyr-Gly-Gly-Phe. Binding of the various compounds to opioid receptor types in guinea pig brain membranes was weak, and the pharmacologic activities in the guinea pig ileum were marginal. These results indicate either that the chosen ligand design does not satisfy the structural requirements of the hypothesized coulombic interaction or that the latter is a minor criterion governing receptor recognition.

  DOI：

  10.1021/jm00113a020

文献信息

• Monoprotection of Triamines with Alkyl Phenyl Carbonates
  作者：Amanda B. Sølvhøj、Christian Tortzen、Jørn B. Christensen

  DOI：10.1080/00304948.2012.697748

  日期：2012.1

  the monoprotection of N1-(2-aminoethyl)-1,2-diaminoethane (1), N1-(3-aminopropyl)-1,3-diaminopropane (6) and N1-(2-aminoethyl)-1,3-diaminopropane (9), which are commercially available, inexpensive and interesting as building blocks for a new family of dendrimers. The regioselective acylation of polyamines has been the subject of considerable interest and is undoubtly related to the versatility of the

  从历史上看，我们一直对使用化学计量的试剂开发用于部分保护多胺并避免使用色谱纯化的简单程序感兴趣。我们之前描述了使用烷基苯基碳酸酯以一般到良好的产率对二胺和三胺进行单保护和双保护。1,2 烷基苯基碳酸酯易于大规模合成并且保质期长。 1 我们感兴趣在N1-(2-氨基乙基)-1,2-二氨基乙烷(1)、N1-(3-氨基丙基)-1,3-二氨基丙烷(6)和N1-(2-氨基乙基)-1,3-的单保护中二氨基丙烷 (9)，它们是可商购的、廉价且有趣的，可作为新的树枝状聚合物家族的构建单元。多胺的区域选择性酰化一直是人们相当感兴趣的主题，无疑与产品的多功能性以及化学家对分子对称性破坏的迷恋有关。由于多胺是多元胺，这表明部分质子化是为某些氨基提供临时保护的策略之一。然而，这种策略需要严格的 pH 控制和对单个 pKb 值的先验知识。Bruice 和 Willis 研究了无环脂肪族 α,ω-二胺与乙酸苯酯的单乙酰化反应，3
• Production processes and systems, compositions, surfactants, monomer units, metal complexes, phosphate esters, glycols, aqueous film forming foams, and foams stabilizers
  申请人：Boggs Janet

  公开号：US20070149437A1

  公开（公告）日：2007-06-28

  Production processes and systems are provided that include reacting halogenated compounds, dehalogenating compounds, reacting alcohols, reacting olefins and a saturated compounds, reacting reactants having at least two —CF 3 groups with reactants having cyclic groups. RF compositions such as R F -intermediates, R F -surfactants, R F -monomers, R F- monomer units, R F -metal complexes, R F -phosphate esters, R F -glycols, R F urethanes, and/or R F -foam stabilizers. The R F portion can include at least two —CF 3 groups, at least three —CF 3 groups, and/or at least two —CF 3 groups and at least two —CH 2 — groups. Detergents, emulsifiers, paints, adhesives, inks, wetting agents, foamers, and defoamers including the R F -surfactant composition are provided. Acrylics, resins, and polymers are provided that include a R F -monomer unit Compositions are provided that include a substrate having a R F -composition thereover. Aqueous Film Forming Foam (“AFFF”) formulations are provided that can include R F -surfactants and/or R F -foam stabilizers are provided.

  提供生产过程和系统，包括反应卤代化合物，脱卤化合物，反应醇，反应烯烃和饱和化合物，将至少含有两个—CF3基团的反应物与具有环状基团的反应物反应。提供RF组分，例如RF中间体，RF表面活性剂，RF单体，RF单体单元，RF金属络合物，RF磷酸酯，RF乙二醇，RF聚氨酯和/或RF泡沫稳定剂。RF部分可以包括至少两个—CF3基团，至少三个—CF3基团，和/或至少两个—CF3基团和至少两个—CH2—基团。提供包括RF表面活性剂组分的清洁剂，乳化剂，油漆，粘合剂，油墨，润湿剂，发泡剂和消泡剂。提供包括RF单体单元的丙烯酸，树脂和聚合物。提供包括具有RF组分的基底的组合物。提供包括RF表面活性剂和/或RF泡沫稳定剂的水性成膜泡沫（“AFFF”）配方。
• An anthracene-based Cd2+ fluorescent chemosensor with a 4,7-bis(2-hydroxyethyl)-9-hydroxy-1,4,7-triazanonyl group as a highly selective chelator to Cd2+ over Zn2+
  作者：Koji Tsukamoto、Shogo Iwasaki、Mari Isaji、Hatsuo Maeda

  DOI：10.1016/j.tetlet.2013.08.055

  日期：2013.11

  We have developed a Cd2+ fluorescent chemosensor with high selectivity as well as sensitivity by tethering a 4,7-bis(2-hydroxyethyl)-9-hydroxy-1,4,7-triazanonyl chelator to anthracene. This sensor features the ability to discriminate Cd2+ from Zn2+ to a high degree (K-dzn/K-dCd = 560) in a pH 7.2 buffer. (C) 2013 Elsevier Ltd. All rights reserved.
• Modification of the enkephalin "message" with an artificial polycationic C-terminus
  作者：Alan R. Jacobson、S. William Tam、Lawrence M. Sayre

  DOI：10.1021/jm00113a020

  日期：1991.9

  The C-terminal ''address'' sequences of prodynorphin-drived opioid peptides contain an unusually high proportion of basic residues, which are known to be crucial for conferring high activity and selectivity for kappa-opioid receptors. In an effort to investigate the possibility that the polycationic ''tails'' may be involved in a coulombic interaction with a complementary polyanionic receptor domain, we attached a series of achiral peptide-like cationic fragments to the C-terminus of the opioid peptide ''message'', Tyr-Gly-Gly-Phe. Binding of the various compounds to opioid receptor types in guinea pig brain membranes was weak, and the pharmacologic activities in the guinea pig ileum were marginal. These results indicate either that the chosen ligand design does not satisfy the structural requirements of the hypothesized coulombic interaction or that the latter is a minor criterion governing receptor recognition.
• A Template Synthesis of Polyamine Macrocycles Containing the 1,1′-Bis(2-phenol) Function
  作者：Mauro Formica、Vieri Fusi、Luca Giorgi、Mauro Micheloni、Pierangela Palma、Roberto Pontellini

  DOI：10.1002/1099-0690(20022)2002:3<402::aid-ejoc402>3.0.co;2-e

  日期：2002.2

  The synthesis of two new polyamine macrocycles, each bearing the 1,1′-bis(2-phenol) group as an integral part of the cyclic framework, is reported. The ligands were obtained by template reactions using a cadmium(II) complex of the suitable polyamine condensed with 3,3′-diformyl-1,1′-bis(2-phenol), followed by selective reduction of the two imine bonds and demetallation in acidic medium.

  报道了两个新的多胺大环的合成，每个大环带有1,1'-双（2-苯酚）基团作为环状骨架的组成部分。通过使用合适的多胺的镉（II）配合物与3,3'-二甲酰基-1,1'-双（2-苯酚）缩合的模板反应获得配体，然后选择性还原两个亚胺键并脱金属在酸性介质中。