1,4,6-trimethyl-2-oxo-1,2-dihydropyrimidine | 15715-27-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,4,6-trimethyl-2-oxo-1,2-dihydropyrimidine
• 英文别名: 1,4,6-trimethyl-2(1H)-pyrimidinone；1,4,6-trimethyl-2-oxopyrimidine；1,4,6-trimethylpyrimidin-2-ones；1,4,6-trimethylpyrimidine-2-one；1,4,6-trimethyl-1H-pyrimidin-2-one；1,4,6-Trimethyl-1H-pyrimidin-2-on；1,4,6-trimethylpyrimidin-2(1H)-one；1,4,6-trimethylpyrimidin-2-one
• CAS: 15715-27-2
• 化学式: C₇H₁₀N₂O
• 分子量: 138.169
• InChiKey: DFIRQBAOBSARLW-UHFFFAOYSA-N

物化性质

• 沸点：
  206.4±23.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,4,6-trimethyl-2-oxo-1,2-dihydropyrimidine 在 劳森试剂 作用下， 以 苯 为溶剂， 反应 4.0h， 以15%的产率得到1,4,6-trimethyl-2(1H)-pyrimidinethione
  参考文献：
  名称：

  Katoh, Akira; Kashima, Choji; Omote, Yoshimori, Heterocycles, 1982, vol. 19, # 12, p. 2283 - 2286

  摘要：

  DOI：
• 作为产物：
  描述：

  4,6-二甲基-1-苯基嘧啶-2-硫酮 在 盐酸 、 silver perchlorate 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成 1,4,6-trimethyl-2-oxo-1,2-dihydropyrimidine
  参考文献：
  名称：

  Kashima, Choji; Katoh, Akira; Yokota, Yuko, Chemical and pharmaceutical bulletin, 1982, vol. 30, # 6, p. 1942 - 1946

  摘要：

  DOI：

文献信息

• Nitrogenous Heterocyclic Derivatives And Their Application In Drugs
  申请人：SUNSHINE LAKE PHARMA CO., LTD.

  公开号：US20150087639A1

  公开（公告）日：2015-03-26

  The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.

  本发明涉及医学领域，提供了新颖的含氮杂环化合物，其制备方法及其作为药物的用途，特别是用于治疗和预防组织纤维化。还提供了包含这些含氮杂环化合物的药用组合物，以及这些组合物在治疗人类或动物组织纤维化方面的用途，特别是用于人类或动物肾间质纤维化、肾小球硬化、肝纤维化、肺纤维化、腹膜纤维化、心肌纤维化、皮肤纤维化、术后粘连、良性前列腺增生、骨骼肌纤维化、硬皮病、多发性硬化、胰腺纤维化、肝硬化、肌肉肉瘤、神经纤维瘤、肺间质纤维化、糖尿病肾病、阿尔茨海默病或血管纤维化。
• Substance for Dyeing Keratinic Fibers
  申请人：Gross Wibke

  公开号：US20070287686A1

  公开（公告）日：2007-12-13

  Compositions suitable for treating keratinic fibers, in particular human hair, are disclosed, which compositions comprise: (i) at least one component selected from the group consisting of salt compounds of general formula I, enamine counterparts of salt compounds of general formula I, and mixtures thereof: wherein each Me represents a methyl group, R represents a substituent selected from the group consisting of an allyl group, a hydroxy-(C 2-6 )-alkyl group, a benzyl group, and substituted benzyl groups, and X − represents a physiologically compatible anion; and (ii) at least one aldehyde selected from the group consisting of 4-hydroxy-3-methoxybenzaldehyde, 3,5-dimethoxy-4-hydroxybenzaldehyde, 4-hydroxy-1-naphthaldehyde, 4-hydroxy-2-methoxybenzaldehyde, 3,4-dihydroxy-5-methoxybenzaldehyde, 3,4,5-tri-hydroxybenzaldehyde, 3,5-dibromo-4-hydroxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, 3-bromo-4-hydroxybenzaldehyde, 4-hydroxy-3-methylbenzaldehyde, 3,5-dimethyl-4-hydroxybenzaldehyde, 5-bromo-4-hydroxy-3-methoxybenzaldehyde, 4-diethylamino-2-hydroxybenzaldehyde, 4-dimethylamino-2-methoxybenzaldehyde, and mixtures thereof.

  本发明涉及适用于处理角蛋白纤维，特别是人类头发的组合物，其中包括以下组成部分：（i）至少一种从一般式I的盐化合物，一般式I的烯胺对应物和它们的混合物中选择的组分：其中每个Me代表一个甲基基团，R代表从烯丙基基团，一个羟基-（C2-6）-烷基基团，苄基和取代苄基基团中选择的取代基团，并且X-代表生理兼容的阴离子；和（ii）至少一种从4-羟基-3-甲氧基苯甲醛，3,5-二甲氧基-4-羟基苯甲醛，4-羟基-1-萘醛，4-羟基-2-甲氧基苯甲醛，3,4-二羟基-5-甲氧基苯甲醛，3,4,5-三羟基苯甲醛，3,5-二溴-4-羟基苯甲醛，4-羟基-3-硝基苯甲醛，3-溴-4-羟基苯甲醛，4-羟基-3-甲基苯甲醛，3,5-二甲基-4-羟基苯甲醛，5-溴-4-羟基-3-甲氧基苯甲醛，4-二乙基氨基-2-羟基苯甲醛，4-二甲基氨基-2-甲氧基苯甲醛和它们的混合物中选择的醛。
• Compositions for treating keratinic fibers, methods of treating such fibers therewith and compounds contained therein
  申请人：Henkel AG & Co. KGaA

  公开号：US07678156B2

  公开（公告）日：2010-03-16

  Compositions suitable for treating keratinic fibers, in particular human hair, are disclosed, which compositions comprise: (i) at least one component selected from the group consisting of salt compounds of general formula I, enamine counterparts of salt compounds of general formula I, and mixtures thereof: Where each Me represents a methyl group, R represents a substituent selected from the group consisting of an allyl group, a hydroxy-(C2-6)-alkyl group, a benzyl group, and substituted benzyl groups, and X− represents a physiologically compatible anion; and (ii) at least one aldehyde selected from the group consisting of 4-hydroxy-3-methoxybenzaldehyde, 3,5-dimethoxy-4-hydroxybenzaldehyde, 4-hydroxy-1-naphthaldehyde, 4-hydroxy-2-methoxybenzaldehyde, 3,4-dihydroxy-5-methoxybenzaldehyde, 3,4,5-trihydroxybenzaldehyde, 3,4-dibromo-4-hydroxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, 3-bromo-4-hydroxybenzaldehyde, 4-hydroxy-3-methylbenzaldehyde, 3,5-dimethyl-4-hydroxy-benzaldehyde, 5-bromo-4-hydroxy-3-methoxybenzaldehyde, 4-diethylamino-2-hydroxybenzaldehyde, 4-dimethylamino-2-methoxybenzaldehyde and mixtures thereof.

  本发明披露了适用于处理角蛋白纤维，特别是人类头发的组合物，其中所述组合物包括：(i)至少一种来自以下化合物组的选择性组分：通式I的盐类化合物，通式I的恩啉对应物，以及它们的混合物：其中每个Me代表一个甲基基团，R代表选自烯丙基基团，羟基-(C2-6)-烷基基团，苄基和取代苄基基团的取代基团，X-代表生理相容的阴离子；以及(ii)至少一种选自以下化合物组的醛类：4-羟基-3-甲氧基苯甲醛，3,5-二甲氧基-4-羟基苯甲醛，4-羟基-1-萘甲醛，4-羟基-2-甲氧基苯甲醛，3,4-二羟基-5-甲氧基苯甲醛，3,4,5-三羟基苯甲醛，3,4-二溴-4-羟基苯甲醛，4-羟基-3-硝基苯甲醛，3-溴-4-羟基苯甲醛，4-羟基-3-甲基苯甲醛，3,5-二甲基-4-羟基苯甲醛，5-溴-4-羟基-3-甲氧基苯甲醛，4-二乙基氨基-2-羟基苯甲醛，4-二甲基氨基-2-甲氧基苯甲醛以及它们的混合物。
• Nishio, Takehiko; Kato, Akira; Kashima, Choji, Journal of the Chemical Society. Perkin transactions I, 1980, p. 607 - 610
  作者：Nishio, Takehiko、Kato, Akira、Kashima, Choji、Omote, Yoshimori

  DOI：——

  日期：——
• Intermediates in the transformation of 1,2-dialkylpyrimidinium iodides in the Kost-Sagitullin rearrangement
  作者：G. G. Danagulyan、D. A. Tadevosyan、F. S. Kinoyan

  DOI：10.1007/s10593-006-0161-8

  日期：2006.6