4-(tert-butyl)-6-methyl-2-aminophenol | 57465-17-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(tert-butyl)-6-methyl-2-aminophenol
• 英文别名: 2-Amino-4-tert-butyl-6-methyl-phenol；2-Amino-4-t-butyl-6-methylphenol；2-Amino-4-tert-butyl-6-methylphenol
• CAS: 57465-17-5
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: OUROFCWPNNYRFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-oxo-acetyl chloride 、 4-(tert-butyl)-6-methyl-2-aminophenol 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-(5-tert-butyl-2-hydroxy-3-methyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide
  参考文献：
  名称：

  [EN] CYTOKINE INHIBITORS
  [FR] INHIBITEURS DES CYTOKINES

  摘要：

  公开号：

  WO2005023761A3
• 作为产物：
  描述：

  5-硝基-6-羟基-1-甲基-3-叔丁基苯 在 溶剂黄146 、 锌 作用下， 生成 4-(tert-butyl)-6-methyl-2-aminophenol
  参考文献：
  名称：

  Reactions of 3,4,6-Trialkylphenols. III. Oxidation Studies

  摘要：

  DOI：

  10.1021/ja01648a068

文献信息

• CYTOKINE INHIBITORS
  申请人：Boman Erik

  公开号：US20100093734A1

  公开（公告）日：2010-04-15

  The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.

  本发明提供了低分子量化合物，可用作细胞因子抑制剂及其组合物。特别是，本发明的化合物可用作抗炎剂。还提供了制备这种药剂的方法，以及其在预防或治疗由细胞因子介导的疾病，如关节炎方面的用途。
• ALPHA-KETOAMIDES AND DERIVATIVES THEREOF
  申请人：Boman Erik

  公开号：US20100273797A1

  公开（公告）日：2010-10-28

  The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.

  本发明提供了低分子量化合物，可用作细胞因子抑制剂及其组合物。特别地，本发明的化合物可用作抗炎剂。还提供了制备这些药剂的方法，并将其用于预防或治疗由细胞因子介导的疾病，例如关节炎。
• 1,2-ALKANE POLYOL-CONTAINING COMPOSITION
  申请人：Osaka Organic Chemical Ind., Ltd.

  公开号：EP2985017A1

  公开（公告）日：2016-02-17

  Provided is a composition containing, as an alkane polyol, a C4-18 1,2-alkane polyol in which the degradation over time of the C4-18 1,2-alkane polyol, which has inferior chemical stability and degrades easily, is suppressed, the composition being suitable for use in a cosmetic, an inkjet ink, a fiber or a coating material such as a paint. A composition containing 1,2-alkane polyol that can be used in a cosmetic, an inkjet ink, a raw material for fibers or a coating material, the alkane polyol being a C4-18 1,2-alkane polyol, and the composition containing a radical scavenger.

  本发明提供了一种含有 C4-18 1,2-烷烃多元醇作为烷烃多元醇的组合物，在该组合物中，化学稳定性较差且容易降解的 C4-18 1,2-烷烃多元醇随时间推移的降解受到抑制，该组合物适用于化妆品、喷墨墨水、纤维或涂料等涂层材料。一种含有 1,2-烷烃多元醇的组合物，可用于化妆品、喷墨墨水、纤维原料或涂层材料，烷烃多元醇为 C4-18 1,2-烷烃多元醇，组合物中含有自由基清除剂。
• Synthesis of substituted amidobenzoate compounds, the compounds obtained and the use thereof as phthalate free internal electron donor for polymerization of olefins
  申请人：SABIC GLOBAL TECHNOLOGIES B.V.

  公开号：US10611864B2

  公开（公告）日：2020-04-07

  The present invention relates to a compound according to Formula (I) wherein R1 is a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, and alkylaryl groups, and one or more combinations thereof; wherein R2 is a hydrogen atom, an aryl group or an alkyl group; and wherein R3, R4, R5 and R6, are the same or different and are each independently a hydrogen atom, a halogen atom, a cyano group, an amino group, a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, and alkylaryl groups or an alkoxy group, and one or more combinations thereof as internal electron donor and to a process for the synthesis of a compound according to Formula (I), wherein R1 is a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, alkoxycarbonyl and alkylaryl groups, and one or more combinations thereof; wherein R2 is a hydrogen atom or an alkyl group; wherein R3, R4, R5 and R6, are the same or different and are each independently selected from a group consisting of a hydrogen atom; a hydrocarbyl, preferably, said process comprising the step of reacting a compound according to Formula (II) [R1—C(═O)Cl] with a compound according to Formula (III) to obtain the compound according to Formula (I) and to the use of these compounds as internal donor in Ziegler-Natta catalysis of olefins.

  本发明涉及一种符合式（I）的化合物 其中 R1 是烃基，选自由烷基、烯基、芳基、芳烷基和烷芳基以及它们的一种或多种组合组成的组； 其中 R2 是氢原子、芳基或烷基；其中 R3、R4、R5 和 R6 相同或不同，各自独立地为氢原子、卤素原子、氰基、氨基、选自烷基、烯基、芳基、芳烷基和烷芳基的烃基或烷氧基、及其一个或多个组合作为内电子供体，并用于合成根据式（I）的化合物的工艺， 其中 R1 是选自由烷基、烯基、芳基、芳烷基、烷氧羰基和烷芳基及其一个或多个组合组成的组的烃基；其中 R2 是氢原子或烷基； 其中 R3、R4、R5 和 R6 相同或不同，且各自独立地选自由氢原子、烃基组成的组，优选地，所述工艺包括将根据式（II）的化合物[R1-C(═O)Cl]与根据式（III）的化合物反应以获得根据式（I）的化合物的步骤，以及将这些化合物用作烯烃的齐格勒-纳塔催化反应中的内部供体。
• [EN] SYNTHESIS OF SUBSTITUTED AMIDOBENZOATE COMPOUNDS, THE COMPOUNDS OBTAINED AND THE USE THEREOF AS PHTHALATE FREE INTERNAL ELECTRON DONOR FOR POLYMERIZATION OF OLEFINS<br/>[FR] SYNTHÈSE DE COMPOSÉS AMIDOBENZOATE SUBSTITUÉS, COMPOSÉS OBTENUS ET UTILISATION DE CES DERNIERS EN TANT QUE DONNEUR D'ÉLECTRONS INTERNE SANS PHTALATE POUR LA POLYMÉRISATION D'OLÉFINES
  申请人：SABIC GLOBAL TECHNOLOGIES BV

  公开号：WO2017050870A9

  公开（公告）日：2018-01-25