3-allyloxazolidine-2,4-dione | 90724-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-allyloxazolidine-2,4-dione
• 英文别名: 3-allyl-oxazolidine-2,4-dione；3-Allyl-oxazolidin-2,4-dion；3-Allyl-oxazolidin-dion-(2,4)；3-Prop-2-enyl-1,3-oxazolidine-2,4-dione
• CAS: 90724-65-5
• 化学式: C₆H₇NO₃
• 分子量: 141.126
• InChiKey: WNIVNEAJDJJHAD-UHFFFAOYSA-N

物化性质

• 沸点：
  72 °C(Press: 5 Torr)
• 密度：
  1.248±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-3-Propenyl hydroxyacetamide 、 碳酸二乙酯 生成 3-allyloxazolidine-2,4-dione
  参考文献：
  名称：

  N-Substituted Oxazolidinediones

  摘要：

  DOI：

  10.1021/ja01533a042

文献信息

• Electrochemical studies on haloamides. Part XII. Electrosynthesis of oxazolidine-2,4-diones
  作者：Maria Antonietta Casadei、Stefania Cesa、Achille Inesi

  DOI：10.1016/0040-4020(95)00257-9

  日期：1995.5

  Electrogenerated bases promote the carboxylation of NH-protic carboxamides bearing a leaving group at the position 2 to give oxazolidine-2,4-diones. The process is believed to involve acid-base reaction with the substrate, carboxylation of its conjugate base to the corresponding carbamate and ring-closure following intramolecular SN2 reaction. A variety of oxazolidine-2,4-diones, including clinically

  电生成的碱促进在位置2带有离去基团的NH-质子型羧酰胺的羧化反应，生成恶唑烷-2,4-二酮。该过程被认为涉及与基板成相应的氨基甲酸盐和闭环以下的分子内S酸性-碱反应，其共轭碱的羧化Ñ 2反应。已经以高至优异的收率制备了各种恶唑烷-2,4-二酮，包括临床使用的trimethadione®和malidone®，确立了这种新的成环方法的范围和通用性。
• N-(2-Hydroxyalkanoyl)-N,N'-Dialkylureas and a process for their preparation
  申请人：Galliani Guido

  公开号：US20080085937A1

  公开（公告）日：2008-04-10

  N-(2-hydroxyalkanoyl)-N,N′-dialkylureas of general formula (1) are described A-X-(A) m (1) where A: m=0 or m=1; when m=0, X=R′″, where R′″ is an aliphatic, cycloaliphatic, arylaliphatic radical, C 1 -C 18 ; when m=1, X=—(CH 2 ) n —, where n is an integer from 1 and 20, preferably from 2 to 6; R is chosen among H, and alkyl radicals C 1 -C 8 , possibly substituted with halogen atoms; R′ is an aliphatic, cycloaliphatic, arylaliphatic radical, C 1 -C 18 ; R″ is chosen among H, aliphatic, cycloaliphatic, arylaliphatic radical, C 1 -C 18 . The preparation of said compounds is described, as well as the preparation of corresponding polymers.

  通用公式（1）中描述了一种N-(2-羟基烷酰基)-N,N′-二烷基脲，其结构为A-X-(A)m(1)，其中A:m=0或m=1；当m=0时，X=R′″，其中R′″是一种脂肪族、环脂族、芳基脂族基团，碳链长度为C1-C18；当m=1时，X=—(CH2)n—，其中n为1到20的整数，最好为2到6；R可为H或烷基基团C1-C8，可能被卤素原子取代；R′为一种脂肪族、环脂族、芳基脂族基团，碳链长度为C1-C18；R″可为H，也可为一种脂肪族、环脂族、芳基脂族基团，碳链长度为C1-C18。描述了所述化合物的制备方法，以及相应聚合物的制备方法。
• Activation of Carbon Dioxide by Electrogenerated Superoxide Ion:  A New Carboxylating Reagent
  作者：Maria Antonietta Casadei、Stefania Cesa、Franco Micheletti Moracci、Achille Inesi、Marta Feroci

  DOI：10.1021/jo9512057

  日期：1996.1.1
• Synthesis of 3-alkyloxazolidin-2,4-diones using 2-chloroacetamides, carbon dioxide and 1,8-diazabicyclo[5.4.0]undecene (DBU)
  作者：Guido Galliani、Bruno Rindone、Francesco Saliu

  DOI：10.1016/j.tetlet.2009.06.109

  日期：2009.9

  Diazabicyclo[5.4.0]undecene (DBU) reacts with carbon dioxide and N-substituted-2-chloroacetoamides in a very simple one-step procedure, to give the corresponding 3-substituted oxazolidin-2,4-diones in excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.
• Davies et al., Journal of the Chemical Society, 1950, p. 34
  作者：Davies et al.

  DOI：——

  日期：——