N-methyl-N-(4-methylbenzyl)prop-2-yn-1-amine | 709-86-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-(4-methylbenzyl)prop-2-yn-1-amine
• 英文别名: <4-Methyl-benzyl>-methyl-propin-(2)-yl-amin；N-methyl-N-[(4-methylphenyl)methyl]prop-2-yn-1-amine
• CAS: 709-86-4
• 化学式: C₁₂H₁₅N
• mdl: MFCD14631444
• 分子量: 173.258
• InChiKey: CENLKUAPIIECBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基炔丙基胺 、 对甲基苯甲醛 在 盐酸 、 sodium cyanoborohydride 作用下， 生成 N-methyl-N-(4-methylbenzyl)prop-2-yn-1-amine
  参考文献：
  名称：

  Synthesis, Biological Evaluation and Quantitative Structure Activity Relationship Analysis of Nuclear-substituted Pargylines as Competitive Inhibitors of MAO-A and MAO-B

  摘要：

  一系列取代核素的帕吉林衍生物已经制备并在受控条件下进行了测试（旨在测量竞争性抑制的成分），作为 MAO-A 和 -B 的竞争性抑制剂。只有当考虑 m- 和 p- 取代衍生物时才能获得生物数据与取代基团的物理化学常数之间的充分相关性。当抑制 MAO-B 时，p- 取代衍生物显示的活性范围较窄，未找到有意义的相关性。然而，通过 m- 取代衍生物对 MAO-B 的抑制需要包括 Verloop L 参数以获得充分的相关性，这表明 MAO-B 的抑制剂结合位点位于比 MAO-A 表面上的尺寸更有限的空腔内。对 MAO-A 和 -B 的抑制表明，抑制活性与 π 之间存在抛物线关系。虽然这种抛物线关系对于 MAO-A 的抑制显示出最大值（平均 πo = 0·86），但对于 MAO-B 的抑制却显示出最小值的 π 值（πmin= −0·5），即尚未达到 MAO-B 抑制的最佳 π 值，但对于这一系列化合物而言，该值将大于 MAO-A 的值。 Hammett σ 函数仅在 p- 取代衍生物抑制 MAO-A 时才显得重要或显著。

  DOI：

  10.1111/j.2042-7158.1991.tb03476.x

文献信息

• A TiO2 immobilized Ru(ii) polyazine complex: a visible-light active photoredox catalyst for oxidative cyanation of tertiary amines
  作者：Pawan Kumar、Sanny Varma、Suman L. Jain

  DOI：10.1039/c3ta14783e

  日期：——

  nanocrystalline TiO2 grafted ruthenium(II) polyazine complex was found to be an efficient visible light photoredox catalyst for the oxidative cyanation of tertiary amines to the corresponding α-aminonitriles in high to excellent yields, using molecular oxygen as an oxidant and sodium cyanide in acetic acid as a cyanide source. The developed photoredox catalyst could be easily recovered by simple filtration

  发现化学功能化的纳米晶TiO 2接枝的钌（II）聚嗪络合物是一种高效的可见光光氧化还原催化剂，使用分子氧作为氧化剂和钠，可以将叔胺氧化氰化成相应的α-氨基腈，而且产率高至优异。乙酸中的氰化物为氰化物来源。所开发的光氧化还原催化剂可以通过简单的过滤容易地回收，并在具有恒定催化活性的情况下重复使用几次。
• A fragment-like approach to PYCR1 inhibition
  作者：Kirsty Milne、Jianhui Sun、Esther A. Zaal、Jenna Mowat、Patrick H.N. Celie、Alexander Fish、Celia R. Berkers、Giuseppe Forlani、Fabricio Loayza-Puch、Craig Jamieson、Reuven Agami

  DOI：10.1016/j.bmcl.2019.07.047

  日期：2019.9

  Pyrroline-5-carboxylate reductase 1 (PYCR1) is the final enzyme involved in the biosynthesis of proline and has been found to be upregulated in various forms of cancer. Due to the role of proline in maintaining the redox balance of cells and preventing apoptosis, PYCR1 is emerging as an attractive oncology target. Previous PYCR1 knockout studies led to a reduction in tumor growth. Accordingly, a small molecule inhibitor of PYCR1 could lead to new treatments for cancer, and a focused screening effort identified pargyline as a fragment-like hit. We report the design and synthesis of the first tool compounds as PYCR1 inhibitors, derived from pargyline, which were assayed to assess their ability to attenuate the production of proline. Structural activity studies have revealed the key determinants of activity, with the most potent compound (4) showing improved activity in vitro in enzyme (IC50 = 8.8 mu M) and pathway relevant effects in cell-based assays.
• MAO INHIBITING N-BENZYL-N-PROPARGYL-AMINES USEFUL FOR TREATING OBESITY
  申请人：McElroy John F.

  公开号：US20080182824A1

  公开（公告）日：2008-07-31

  The invention provides novel N-benzyl-N-propargyl-amines that are monoamine oxidase inhibitors, but generally exhibit little or no CNS effects.
• US8124802B2
  申请人：——

  公开号：US8124802B2

  公开（公告）日：2012-02-28