2-(2-Methylphenyl)-3,6-dihydrooxazine-6-carboxylic acid | 1257308-20-5

• 分子结构分类: 有机化合物 - 苯类化合物 - N-苯基羟胺
• 英文名称: 2-(2-Methylphenyl)-3,6-dihydrooxazine-6-carboxylic acid
• 英文别名: 2-(2-methylphenyl)-3,6-dihydrooxazine-6-carboxylic acid
• CAS: 1257308-20-5
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: ISOOKOBTTIHJQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-戊二烯酸 、 厄多司坦 以 N,N-二甲基甲酰胺 为溶剂， 95.0 ℃ 、100.0 kPa 条件下， 反应 0.78h， 以75%的产率得到2-(2-Methylphenyl)-3,6-dihydrooxazine-6-carboxylic acid
  参考文献：
  名称：

  Straightforward hetero Diels–Alder reactions of nitroso dienophiles by microreactor technology

  摘要：

  The hetero Diels-Alder reactions of 2-nitrosotoluene and some representative acylnitrosodienophiles with a selected set of 1,3-dienes were studied under microflow conditions. The main assets of the technology, that is, an accurate control of the reaction parameters and continuous operating, led to an increased efficiency of this reaction. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.117

文献信息

• Straightforward hetero Diels–Alder reactions of nitroso dienophiles by microreactor technology
  作者：Jean-Christophe M.R. Monbaliu、Ana Cukalovic、Jacqueline Marchand-Brynaert、Christian V. Stevens

  DOI：10.1016/j.tetlet.2010.08.117

  日期：2010.11

  The hetero Diels-Alder reactions of 2-nitrosotoluene and some representative acylnitrosodienophiles with a selected set of 1,3-dienes were studied under microflow conditions. The main assets of the technology, that is, an accurate control of the reaction parameters and continuous operating, led to an increased efficiency of this reaction. (C) 2010 Elsevier Ltd. All rights reserved.