1-(1,2-diphenyl)-1H-imidazole | 99369-23-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(1,2-diphenyl)-1H-imidazole
• 英文别名: 1-(1,2-Diphenylethyl)imidazole
• CAS: 99369-23-0
• 化学式: C₁₇H₁₆N₂
• 分子量: 248.327
• InChiKey: FFQCWOTUCCPLPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(1,2-diphenyl)-1H-imidazole 、 1,5-萘二磺酸 以 乙醇 为溶剂， 生成 1-(1,2-Diphenyl-ethyl)-1H-imidazole; compound with naphthalene-1,5-disulfonic acid
  参考文献：
  名称：

  α-Lithiation ofN-Arylmethylimidazoles and Triazoles: A General Method for the Synthesis of 1,2-Diaryl-1-(N-azolyl)-ethanes

  摘要：

  DOI：

  10.1055/s-1985-31187
• 作为产物：
  描述：

  二苯基乙酮 在 copper acetylacetonate 、 水 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 甲醇 、 氟苯 为溶剂， 反应 2.0h， 生成 1-(1,2-diphenyl)-1H-imidazole
  参考文献：
  名称：

  乙酰丙酮铜[铜（ACAC）2 ] / BINAP-推荐Ç SP 3 N键的形成通过还原偶联Ñ -Tosylhydrazones与苯胺

  摘要：

  AbstractWe report the the copper(II) acetoacetonate [Cu(acac)2]/BINAP‐catalyzed synthesis of arylamines from N‐tosylhydrazones and anilines. A fine tuning of the reaction conditions was required to accomplish the cross‐coupling successfully, including the ligands effect and the addition of small amounts of water. The characteristic feature of this protocol is its functional group compatibility and its chemoselectivity when various aminophenol derivatives were used. Taking into consideration the interest for this copper‐reductive coupling in which no stoichiometric metal hydride reagent is employed, this can be considered as an alternative to the conventional reductive amination.magnified image

  DOI：

  10.1002/adsc.201300466

文献信息

• Moreno-Manas, M.; Bassa, J.; Llado, N., Journal of Heterocyclic Chemistry, 1990, vol. 27, # 3, p. 673 - 678
  作者：Moreno-Manas, M.、Bassa, J.、Llado, N.、Pleixats, R.

  DOI：——

  日期：——
• CUBERES, M. R.;MORENO-MANAS, M.;TRIUS, A., SYNTHESIS, BRD, 1985, N 3, 302-304
  作者：CUBERES, M. R.、MORENO-MANAS, M.、TRIUS, A.

  DOI：——

  日期：——
• Copper Acetoacetonate [Cu(acac)₂]/BINAP-Promoted C<i>sp</i>³N Bond Formation<i>via</i>Reductive Coupling of<i>N</i>-Tosylhydrazones with Anilines
  作者：Jessy Aziz、Jean-Daniel Brion、Abdallah Hamze、Mouad Alami

  DOI：10.1002/adsc.201300466

  日期：2013.8.12

  AbstractWe report the the copper(II) acetoacetonate [Cu(acac)2]/BINAP‐catalyzed synthesis of arylamines from N‐tosylhydrazones and anilines. A fine tuning of the reaction conditions was required to accomplish the cross‐coupling successfully, including the ligands effect and the addition of small amounts of water. The characteristic feature of this protocol is its functional group compatibility and its chemoselectivity when various aminophenol derivatives were used. Taking into consideration the interest for this copper‐reductive coupling in which no stoichiometric metal hydride reagent is employed, this can be considered as an alternative to the conventional reductive amination.magnified image
• α-Lithiation of<i>N</i>-Arylmethylimidazoles and Triazoles: A General Method for the Synthesis of 1,2-Diaryl-1-(<i>N</i>-azolyl)-ethanes
  作者：María Rosa Cuberes、Marcial Moreno-Mañas、Antonio Trius

  DOI：10.1055/s-1985-31187

  日期：——