Diacetyldiphenylurea bisguanylhydrazone | 13284-07-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Diacetyldiphenylurea bisguanylhydrazone
• 英文别名: 1,3-bis[4-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]urea
• CAS: 13284-07-6
• 化学式: C₁₉H₂₄N₁₀O
• 分子量: 408.5
• InChiKey: HCAQGQIHBFVVIX-LYXAAFRTSA-N

物化性质

• 物理描述：
  Insoluble in water. (NTP, 1992)
• 溶解度：
  Insoluble (NTP, 1992)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  195
• 氢给体数：
  6
• 氢受体数：
  5

文献信息

• Use of Chk2 Kinase Inhibitors for Cancer Treatment
  申请人：Pommier Yves

  公开号：US20100069423A1

  公开（公告）日：2010-03-18

  Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
• COMPOSITIONS USEFUL FOR TREATING HERPES SIMPLEX KERATITIS, AND METHODS USING SAME
  申请人：Drexel University

  公开号：US20150080390A1

  公开（公告）日：2015-03-19

  The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes simplex keratitis, in a subject. In certain embodiments, the compositions of the present invention comprise an ATM inhibitor and an anti-herpetic agent. In other embodiments, the compositions comprise a Chk2 inhibitor and an anti-herpetic agent. In yet other embodiments, the compositions comprise a Chk2 inhibitor and an ATM inhibitor, and optionally an anti-herpetic agent.
• Compositions Useful for Treating Herpes Simplex Labialis and/or Herpes Esophagitis, and Methods Using Same
  申请人：Clifford Jane E.

  公开号：US20160089372A1

  公开（公告）日：2016-03-31

  The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes simplex labialis or herpes esophagitis, in a subject. In certain embodiments, the compositions of the invention comprise an ATM inhibitor and an anti-herpetic agent. In other embodiments, the compositions comprise a Chk2 inhibitor and an anti-herpetic agent. In yet other embodiments, the compositions comprise a Chk2 inhibitor and an ATM inhibitor, and optionally an anti-herpetic agent.
• Compositions Useful for Treating Herpes Simplex Keratitis, and Methods Using Same
  申请人：DREXEL UNIVERSITY

  公开号：US20170056410A1

  公开（公告）日：2017-03-02

  The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes simplex keratitis, in a subject. In certain embodiments, the compositions of the present invention comprise an ATM inhibitor and an anti-herpetic agent. In other embodiments, the compositions comprise a Chk2 inhibitor and an anti-herpetic agent. In yet other embodiments, the compositions comprise a Chk2 inhibitor and an ATM inhibitor, and optionally an anti-herpetic agent.
• US8765802B2
  申请人：——

  公开号：US8765802B2

  公开（公告）日：2014-07-01