1-methyl-1-phenyl-3-propylurea | 63098-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methyl-1-phenyl-3-propylurea
• 英文别名: N-Methyl-N-phenyl-N'-propylurea
• CAS: 63098-94-2
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: NGOIMSHGDCPKRL-UHFFFAOYSA-N

物化性质

• 沸点：
  353.6±15.0 °C(Predicted)
• 密度：
  1.051±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  正丙胺 、 methyl-phenyl-carbamic acid-(2,2,2-trichloro-ethyl ester) 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以85%的产率得到1-methyl-1-phenyl-3-propylurea
  参考文献：
  名称：

  催化 DBU 由氨基甲酸三氯乙酯直接合成不对称脲化合物

  摘要：

  DOI：

  10.1002/bkcs.11314

文献信息

• One-pot synthesis of trisubstituted ureas from α-chloroaldoxime O-methanesulfonates and secondary amines
  作者：Juthanat Kaeobamrung、Asan Lanui、Sirinad Mahawong、Witthawin Duangmak、Vatcharin Rukachaisirikul

  DOI：10.1039/c5ra10060g

  日期：——

  Trisubstituted ureas can be synthesized in a one-pot fashion from bench-stable α-chloroaldoxime O-methanesulfonates and secondary amines under mild reaction conditions.

  三取代脲可以在温和的反应条件下从稳定的α-氯代aldoxime O-甲磺酸酯和二级胺一锅法合成。
• Methods for modulating taste receptors
  申请人：MARS, INCORPORATED

  公开号：US11185100B2

  公开（公告）日：2021-11-30

  Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

  本文描述了存在于鲜味受体结构域中的氨基酸，其中氨基酸与至少一种核苷酸衍生物和/或至少一种跨膜化合物相互作用，从而增强、调节、增加和/或提高鲜味受体的活性。此类化合物可用于调味组合物，以增强食品的鲜味和/或适口性。
• FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME
  申请人：MARS, INCORPORATED

  公开号：US20180168208A1

  公开（公告）日：2018-06-21

  A flavor composition comprising at least one nucleotide derivative and/or at least one transmembrane compound that modulates, increases and/or enhances the activity of an umami receptor is provided that can be used to enhance the umami taste and/or palatability of food products. In certain, non-limiting embodiments, the flavor composition comprises at least one nucleotide derivative and/or at least one transmembrane compound, optionally at least one nucleotide, optionally at least one first amino acid, optionally at least one second amino acid.
• METHODS FOR MODULATING TASTE RECEPTORS
  申请人：MARS, INCORPORATED

  公开号：US20180255813A1

  公开（公告）日：2018-09-13

  Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.
• [EN] IMMUNOMODULATING UREA AZALIDES<br/>[FR] AZALIDES D'URÉE IMMUNOMODULATEURS
  申请人：ZOETIS SERVICES LLC

  公开号：WO2021183758A1

  公开（公告）日：2021-09-16

  Defined herein are immunomodulating Formula (1) compounds wherein R, R0, R1, R2,R3 and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.