2-(4-methoxyphenyl)-2-(trifluoromethyl)-pyrrolidine | 1262380-91-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-(4-methoxyphenyl)-2-(trifluoromethyl)-pyrrolidine
• 英文别名: 2-(4-Methoxyphenyl)-2-(trifluoromethyl)-pyrrolidine；2-(4-methoxyphenyl)-2-(trifluoromethyl)pyrrolidine
• CAS: 1262380-91-5
• 化学式: C₁₂H₁₄F₃NO
• 分子量: 245.244
• InChiKey: AWBFVJNYQZRFCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(4-甲氧基苯基)-3,4-二氢-2H-吡咯 、 (三氟甲基)三甲基硅烷 在 二氟化氢钾 、 三氟乙酸 作用下， 以 乙腈 为溶剂， 以49%的产率得到2-(4-methoxyphenyl)-2-(trifluoromethyl)-pyrrolidine
  参考文献：
  名称：

  The reaction of cyclic imines with the Ruppert–Prakash reagent. Facile approach to α-trifluoromethylated nornicotine, anabazine, and homoanabazine

  摘要：

  We have demonstrated that the Ruppert-Prakash reagent is able to react with a number of cyclic imines under acidic condition to afford the corresponding alpha-trifluoromethyl derivatives of nitrogen heterocycles. 5-7-Membered cyclic imines bearing various alkyl, aryl or heterocyclic group were successfully involved in this transformation. Novel trifluoromethylated analogues of nicotine, anabasine, and homoanabasine alkaloids were synthesized. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.11.032

文献信息

• The reaction of cyclic imines with the Ruppert–Prakash reagent. Facile approach to α-trifluoromethylated nornicotine, anabazine, and homoanabazine
  作者：Nikolay E. Shevchenko、Katja Vlasov、Valentine G. Nenajdenko、Gerd-Volker Röschenthaler

  DOI：10.1016/j.tet.2010.11.032

  日期：2011.1

  We have demonstrated that the Ruppert-Prakash reagent is able to react with a number of cyclic imines under acidic condition to afford the corresponding alpha-trifluoromethyl derivatives of nitrogen heterocycles. 5-7-Membered cyclic imines bearing various alkyl, aryl or heterocyclic group were successfully involved in this transformation. Novel trifluoromethylated analogues of nicotine, anabasine, and homoanabasine alkaloids were synthesized. (C) 2010 Elsevier Ltd. All rights reserved.