N-hydroxy-2-mesityl-2-phenylacetimidoyl chloride | 1140906-84-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-hydroxy-2-mesityl-2-phenylacetimidoyl chloride
• CAS: 1140906-84-8
• 化学式: C₁₇H₁₈ClNO
• 分子量: 287.789
• InChiKey: UWMNJPJQPZETIA-UHFFFAOYSA-N

物化性质

• 熔点：
  113 °C
• 沸点：
  449.7±55.0 °C(predicted)
• 密度：
  1.11±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.77
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  β-硝基苯乙烯 、 均三甲苯 在 aluminum (III) chloride 作用下， 以 二氯甲烷 为溶剂， 以88%的产率得到N-hydroxy-2-mesityl-2-phenylacetimidoyl chloride
  参考文献：
  名称：

  An efficient method for the synthesis of α-arylated nitroalkanes and α-arylated hydroximoyl chlorides mediated by AlCl3

  摘要：

  Friedel-Crafts alkylation of various arenes/heteroarenes to beta-nitrostyrenes mediated by aluminum chloride is described. The interesting feature of this methodology pertain the formation of different products by tuning the reaction temperature. alpha-Arylated nitroalkanes were formed predominately at -78 degrees C, whereas alpha-arylated hydroximoyl chlorides were obtained at room temperature without any side products in high yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.01.075

文献信息

• An efficient method for the synthesis of α-arylated nitroalkanes and α-arylated hydroximoyl chlorides mediated by AlCl3
  作者：Zhijay Tu、B. Rama Raju、Tzuo-Rung Liou、Veerababurao Kavala、Chun-Wei Kuo、Yaochung Jang、Yu-Hsuan Shih、Chun-Chao Wang、Ching-Fa Yao

  DOI：10.1016/j.tet.2009.01.075

  日期：2009.3

  Friedel-Crafts alkylation of various arenes/heteroarenes to beta-nitrostyrenes mediated by aluminum chloride is described. The interesting feature of this methodology pertain the formation of different products by tuning the reaction temperature. alpha-Arylated nitroalkanes were formed predominately at -78 degrees C, whereas alpha-arylated hydroximoyl chlorides were obtained at room temperature without any side products in high yields. (C) 2009 Elsevier Ltd. All rights reserved.