Mono(papa-cresyl) carbonate | 1260082-40-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Mono(papa-cresyl) carbonate
• 英文别名: (4-methylphenyl) hydrogen carbonate
• CAS: 1260082-40-3
• 化学式: C₈H₈O₃
• 分子量: 152.15
• InChiKey: NQJCGWSRIVAROT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] KETAL ESTER DERIVATIVES<br/>[FR] DÉRIVÉS CÉTO-ESTERS
  申请人：SEGETIS INC

  公开号：WO2010036884A1

  公开（公告）日：2010-04-01

  The present disclosure relates to the preparation of acrylate, alkacrylate, allyl, and polycarbonate derivatives of hydroxy ketal esters, and uses thereof.

  本公开涉及羟基缩醛酮酯的丙烯酸酯、烯丙酸酯、烯丙基和聚碳酸酯衍生物的制备以及它们的用途。
• Penem derivatives and antimicrobial agents containing the same
  申请人：SUNTORY LIMITED

  公开号：EP0774465A1

  公开（公告）日：1997-05-21

  Penem derivatives represented by the following Formula (I): wherein Z represents a hydroxyl group or a fluorine atom, R1 represents a substituted or unsubstituted alkyl, alkenyl, aralkyl group, aryl group, heterocyclic, or acyl group, or a hydrogen atom, and R2 represents a hydrogen atom or a carboxyl-protecting group; and pharmacologically acceptable salts thereof are antibacterial agents effective against, inter alia, methicillin-resistant Staphylococcus aureus. The derivatives and salts are novel except when R1 is ethyl and Z is hydroxyl. The analogous compounds in which R2 is a carboxyl-protecting group and any hydroxyl group represented by Z is protected are novel process intermediates.

  Penem衍生物由以下公式（I）表示：其中Z代表一个羟基团或氟原子，R1代表一个取代或未取代的烷基，烯基，芳基甲基，芳基，杂环基或酰基，或氢原子，R2代表一个氢原子或羧基保护基；及其药理学上可接受的盐是有效的抗菌剂，可用于治疗耐甲氧西林金黄色葡萄球菌等感染。这些衍生物和盐是新颖的，除非R1是乙基且Z是羟基。其中R2是羧基保护基且Z代表的任何羟基被保护的类似化合物是新颖的工艺中间体。
• [EN] TUBULYSIN COMPOUNDS AND CONJUGATES THEREOF<br/>[FR] COMPOSÉS DE TUBULYSINE ET LEURS CONJUGUÉS
  申请人：MERSANA THERAPEUTICS INC

  公开号：WO2014160360A1

  公开（公告）日：2014-10-02

  A tubulysin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by Lp. Each occurrence of D is independently a tubulysin compound having a molecular weight < 5 kDa. LD and Lp are distinct linkers connecting the tubulysin compound and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-tubulysin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

  本文提供了一种管状霉素化合物结合物。该结合物包括基于蛋白质的识别分子（PBRM）和与一个或多个-LD-D取代的聚合物载体，其中基于蛋白质的识别分子通过Lp连接到聚合物载体上。每个D的出现独立地是具有分子量<5 kDa的管状霉素化合物。LD和Lp是连接管状霉素化合物和PBRM到聚合物载体的不同连接物。还公开了用于与PBRM结合形成本文所述聚合物-管状霉素化合物-PBRM结合物的聚合物支架，包括结合物的组合物，其制备方法，以及使用结合物或其组合物治疗各种疾病的方法。
• Penem derivatives and antimicrobial agent containing the same
  申请人：Ishiguro Masaji

  公开号：US20050004092A1

  公开（公告）日：2005-01-06

  A penem derivative represented by the following formula (I): wherein R 1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkylthio group, a substituted or unsubstituted alkenylthio group, a substituted or unsubstituted aralkylthio group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted heterocyclic thio group, a substituted or unsubstituted acylthio group, a mercapto group or a hydrogen atom, and R 2 represents a hydrogen atom or a carboxyl-protecting group; or a pharmacologically acceptable salt thereof. The compound (I) exhibits strong antibacterial activities, and especially, shows strong activities against MRSA. It is therefore useful not only as a general antibacterial agent but also as an antibacterial agent for MRSA against which no general antibacterial agents are recognized to be-effective.

  以下是公式（I）所代表的一种青霉烷衍生物： 其中，R1代表取代或未取代的烷基、取代或未取代的烯基、取代或未取代的芳基烷基、取代或未取代的芳基、取代或未取代的烷基硫基、取代或未取代的烯基硫基、取代或未取代的芳基烷基硫基、取代或未取代的芳基硫基、取代或未取代的杂环基、取代或未取代的杂环硫基、取代或未取代的酰基硫基、巯基或氢原子，R2代表氢原子或羧酸保护基；或其药学上可接受的盐。该化合物（I）表现出强大的抗菌活性，特别是对MRSA表现出强大的活性。因此，它不仅有用作一般抗菌剂，还有用作抗MRSA的抗菌剂，对于这种细菌，一般的抗菌剂被认为无效。
• Quinophthalone Compound, Mixed Colorant, Laser Ray Transmitting Colored Resin Composition, and Laser-Welded Product
  申请人：Sugawara Shuji

  公开号：US20070254984A1

  公开（公告）日：2007-11-01

  Quinophthalone compound of Formula (1) or (2), mixed colorant, laser ray transmitting colored resin composition containing thereof, and laser-welded product. in each of Formulas (1) and (2), X: —O-L; L : hydrogen atom, alkyl, aryl; Y represents hydrogen atom, hydroxyl, mercapto, alkoxy, aryloxy, heterocyclic oxy, acyloxy, alkylsulfonyloxy, arylsulfonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, alkylthio, arylthio, heterocyclic thio; R 1 to R 8 and R 1 to R 4 and R 9 to R 14 : hydrogen atom, nitro, hydroxyl, mercapto, carboxyl, cyano, thiocyano, halogen atom, alkyl, cycloalkyl, aryl, amino, acyl, alkoxy, aryloxy, heterocyclic oxy, acyloxy, alkylsulfonyloxy, arylsulfonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, alkoxycarbonyl, cycloalkyloxycarbonyl, aryloxycarbonyl, heterocyclic oxycarbonyl, carbamoyl, sulfamoyl, alkylsulfonyl, arylsulfonyl, alkylthio, arylthio, heterocyclic thio, alkoxysulfonyl, cycloalkyloxysulfonyl, aryloxysulfonyl, heterocyclic oxysulfonyl; at least one of R 5 to R 8 in Formula (1) is carboxyl, at least one of R 9 to R 14 in Formula (2) is carboxyl.

  公式（1）或（2）中的喹喔酮化合物，混合着色剂，含有其的激光透射着色树脂组合物和激光焊接产品。在每个公式（1）和（2）中，X：—O-L; L：氢原子，烷基，芳基；Y代表氢原子，羟基，巯基，烷氧基，芳氧基，杂环氧基，酰氧基，烷基磺酰氧基，芳基磺酰氧基，烷氧羰基氧基，芳氧羰基氧基，烷硫基，芳硫基，杂环硫基；R1至R8和R1至R4和R9至R14：氢原子，硝基，羟基，巯基，羧基，氰基，硫氰基，卤素原子，烷基，环烷基，芳基，氨基，酰基，烷氧基，芳氧基，杂环氧基，酰氧基，烷基磺酰氧基，芳基磺酰氧基，烷氧羰基氧基，芳氧羰基氧基，烷氧羰基，环烷氧羰基，芳氧羰基，杂环氧羰基，氨基甲酰基，磺酰胺基，烷基磺酰基，芳基磺酰基，烷硫基，芳硫基，杂环硫基，烷氧基磺酰基，环烷氧基磺酰基，芳氧基磺酰基，杂环氧基磺酰基；在公式（1）中的R5至R8中至少有一个是羧基，在公式（2）中的R9至R14中至少有一个是羧基。