4-chloro-N²,N²-dimethyl-o-phenylenediamine | 1022250-60-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-chloro-N²,N²-dimethyl-o-phenylenediamine
• 英文别名: 4-Chlor-N²,N²-dimethyl-o-phenylendiamin；4-chloro-2-(dimethylamino)aniline；4-chloro-N2,N2-dimethylbenzene-1,2-diamine；4-chloro-2-N,2-N-dimethylbenzene-1,2-diamine
• CAS: 1022250-60-7
• 化学式: C₈H₁₁ClN₂
• 分子量: 170.642
• InChiKey: RDROFMHXMLZWTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯-2-碘硝基苯 在 乙醇 、 铁粉 、 溶剂黄146 作用下， 生成 4-chloro-N²,N²-dimethyl-o-phenylenediamine
  参考文献：
  名称：

  LXIX.—3-卤代-6-硝基和-6-氨基-二甲基苯胺

  摘要：

  DOI：

  10.1039/jr9300000497

文献信息

• BENZIMIDAZOLE COMPOUNDS
  申请人：Aso Kazuyoshi

  公开号：US20100056515A1

  公开（公告）日：2010-03-04

  There is provided a compound of the formula (I): wherein R 1 is an optionally substituted C 1-10 alkyl; R 2 is H, or a C 1-6 alkyl which may be substituted with 1 to 3 substituents; R 3 is a 5- or 6-membered aromatic group which may be substituted with 1 to 5 substituents, wherein the 5- or 6-membered aromatic group may be fused with a 5- or 6-membered ring which may be substituted with 1 to 3 C 1-6 alkyls; R 4 is a hydrogen, a halogen, a hydroxy, a cyano, a C 1-6 alkyl or a C 1-6 alkoxy; Z is —O—, —S—, —SO—, —SO 2 —, or —NR 5 — wherein R 5 is a hydrogen or a C 1-6 alkyl; or a salt thereof or a prodrug thereof, which have CRF receptor antagonist activity and use thereof.

  提供了一个式子(I)的化合物： 其中，R1是可选取代的C1-10烷基；R2是氢，或者是一个C1-6烷基，该烷基可以用1至3个取代基取代；R3是一个5-或6-成员芳香基团，可以用1至5个取代基取代，其中5-或6-成员芳香基团可以与一个5-或6-成员环融合，该环可以用1至3个C1-6烷基取代；R4是氢、卤素、羟基、氰基、C1-6烷基或C1-6烷氧基；Z是-O-、-S-、-SO-、-SO2-或-NR5-，其中R5是氢或C1-6烷基；或其盐或前药，具有CRF受体拮抗活性和使用方法。
• METHOD FOR PRODUCING BIARYL COMPOUND
  申请人：Sato Koichi

  公开号：US20100087680A1

  公开（公告）日：2010-04-08

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种制备双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱的存在下，将芳香有机化合物与选自芳香基有机硼化合物和硼氧化物化合物组的至少一种化合物反应。
• Fluorination Process of Anilide Derivatives and Benzothiazole Fluorinate Derivatives as in VIVO Imaging Agents
  申请人：Storey Anthony Eamon

  公开号：US20100234611A1

  公开（公告）日：2010-09-16

  The invention relates to a process for preparation of a compound of formula (I): R 1 is selected from C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; which comprises: (i) reaction with fluoride, suitably [ 18 F]fluoride, of a corresponding compound of formula (II): wherein R 2 is selected from hydrogen, C 1-10 alkyl, C 1-10 haloalkyl, C 6-14 aryl, C 6-14 arylalkyl, —(CH 2 CH 2 O) q —CH 3 wherein q is an integer of from 1 to 10; R 1 is as defined for the compound of formula (I); and R 3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

  本发明涉及一种制备式(I)化合物的方法：其中R1选自C1-6烷基，C2-6烯基和C2-6炔基; 包括：(i)用氟化物，适宜地[18F]氟化物，与式(II)的相应化合物反应：其中R2选自氢，C1-10烷基，C1-10卤代烷基，C6-14芳基，C6-14芳基烷基，—(CH2CH2O)q—CH3，其中q为1至10的整数; R1如式(I)的化合物所定义; R3是一个离去基团。还声明了某些新型的式(II)的前体和含有这些前体的放射性药物配套件。
• FLUORINATION PROCESS
  申请人：GE HEALTHCARE LIMITED

  公开号：US20130225829A1

  公开（公告）日：2013-08-29

  The invention relates to a process for preparation of a compound of formula (I): R 1 is selected from C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; which comprises: (i) reaction with fluoride, suitably [ 18 F]fluoride, of a corresponding compound of formula (II): wherein R 2 is selected from hydrogen, C 1-10 alkyl, C 1-10 haloalkyl, C 6-14 aryl, C 6-14 arylalkyl, —(CH 2 CH 2 O) q —CH 3 wherein q is an integer of from 1 to 10; R 1 is as defined for the compound of formula (I); and R 3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

  本发明涉及一种制备式(I)化合物的过程：其中R1选自C1-6烷基，C2-6烯基和C2-6炔基；包括以下步骤：(i)用氟化物，适当地是[18F]氟化物，与相应的式(II)化合物反应：其中R2选自氢，C1-10烷基，C1-10卤代烷基，C6-14芳基，C6-14芳基烷基，—(CH2CH2O)q—CH3，其中q是1到10的整数；R1如式(I)化合物定义；且R3是一个离去基团。还声明了某些新型的式(II)前体和包含这种前体的放射性药物套装。
• Fluorination Process
  申请人：GE Healthcare Limited

  公开号：US20150328344A1

  公开（公告）日：2015-11-19

  The invention relates to a process for preparation of a compound of formula (I): R 1 is selected from C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl; which comprises: (i) reaction with fluoride, suitably [ 18 F]fluoride, of a corresponding compound of formula (II): wherein R 2 is selected from hydrogen, C 1-10 alkyl, C 1-10 haloalkyl, C 6-14 aryl, C 6-14 arylalkyl, —(CH 2 CH 2 O) q —CH 3 wherein q is an integer of from 1 to 10; R 1 is as defined for the compound of formula (I); and R 3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

  本发明涉及一种制备式（I）化合物的过程：其中R1选择自C1-6烷基，C2-6烯基和C2-6炔基；包括以下步骤：（i）用氟化物，适宜地用[18F]氟化物，反应对应的式（II）化合物：其中R2选择自氢，C1-10烷基，C1-10卤代烷基，C6-14芳基，C6-14芳基烷基，—（CH2CH2O）q—CH3，其中q为1至10的整数；R1如式（I）化合物定义；和R3是一个离去基团。还声明了某些新的式（II）前体和包含这些前体的放射性药剂组。