2-(dimethylamino)-N,N-dimethylbenzamide | 56042-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(dimethylamino)-N,N-dimethylbenzamide
• 英文别名: 2-dimethylamino-N,N-dimethylbenzamide；N,N-Dimethylanthranilsaeure-dimethylamid；N,N-Dimethyl-2-(dimethylamino)benzamid
• CAS: 56042-97-8
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: UCJNVDGEDDYVCJ-UHFFFAOYSA-N

物化性质

• 沸点：
  163-167 °C(Press: 15 Torr)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(dimethylamino)-N,N-dimethylbenzamide 在 劳森试剂 作用下， 以 甲苯 为溶剂， 以42%的产率得到(+/-)-2-dimethylamino-N,N-dimethylthiobenzamide
  参考文献：
  名称：

  Chiroptical detection during liquid chromatography, part 5: On-line measurement of circular dichroism spectra ??(?) during stops of chromatographic flow

  摘要：

  A procedure is described which serves to measure circular dichrograms DELTAepsilon (lambda) on line during stops of flow in liquid chromatography. Since the concentration of substrate in the spectrometer cell during the stop is not known, the differential absorption coefficients DELTAepsilon are calculated from the experimental differential absorbances DELTAA by means of UV absorption (i.e. photomultiplier voltage) data. Verifications of the procedure are obtained by its application to three substrates (Table 1), the DELTAepsilon (lambda) spectra of which were known. The present on-line technique is compared with a corresponding off-line method.The N,N-dimethylthiobenzamides 1 and 2 as well as the 9,10-phenanthrenequinone 7 consist of interconvertible enantiomers because their planar states are destabilized by steric overcrowding of groups. The unknown dichrograms DELTAepsilon (lambda) of 1, 2 and 7 are obtained (Figs. 2 and 4) and discussed with reference to the helicities of these molecules.

  DOI：

  10.1007/bf00810937
• 作为产物：
  描述：

  2-(三甲基硅)苯基三氟甲烷磺酸盐 、 1,1,3,3-四甲基脲 在 cesium fluoride 作用下， 反应 8.0h， 以55%的产率得到2-(dimethylamino)-N,N-dimethylbenzamide
  参考文献：
  名称：

  Addition of Ureas to Arynes: Straightforward Synthesis of Benzodiazepine and Benzodiazocine Derivatives

  摘要：

  DOI：

  10.1002/1521-3773(20020902)41:17<3247::aid-anie3247>3.0.co;2-p

文献信息

• MODULATORS OF THE RELAXIN RECEPTOR 1
  申请人：The United States of America, as Represented by the Secretary, Dept. of Health & Human Services

  公开号：US20150119426A1

  公开（公告）日：2015-04-30

  Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R 1 , and R 2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e.g., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method for therapeutic intervention in a facet of mammalian health that is mediated by a human relaxin receptor 1.

  本文揭示了人类松弛素受体1的调节剂，例如，公式（I）中的A、R1和R2如本文所定义，这些调节剂在治疗哺乳动物松弛素受体1介导的人类健康方面，例如心血管疾病中是有用的。还公开了一种包含药用适宜载体和本公开的至少一种化合物的组合物，以及一种用于治疗介导人类松弛素受体1的哺乳动物健康方面的干预方法。
• General method for nucleophilic aromatic substitution of aryl fluorides and chlorides with dimethylamine using hydroxide-assisted decomposition of N,N-dimethylforamide
  作者：Juana Garcia、Jacob Sorrentino、Emily J. Diller、Daniel Chapman、Zachary R. Woydziak

  DOI：10.1080/00397911.2016.1147051

  日期：2016.3.3

  and convenient procedure for the nucleophilic aromatic substitution of aryl fluorides and chlorides with dimethylamine was developed using a hydroxide-assisted thermal decomposition of N,N-dimethylforamide. These conditions are tolerant of nitro, nitrile, aldehyde, ketone, and amide groups but will undergo acyl substitution to form amides for methyl esters and acyl chlorides. Isolated yields of the products

  摘要 利用 N,N-二甲基甲酰胺的氢氧化物辅助热分解，开发了一种实用且方便的方法，用于芳基氟化物和氯化物与二甲胺的亲核芳香取代。这些条件耐受硝基、腈、醛、酮和酰胺基团，但会发生酰基取代以形成甲酯和酰氯的酰胺。产品的分离产率范围为 44% 至 98%，其中 17 个实例的大多数产率大于 70%。图形概要
• US9452973B2
  申请人：——

  公开号：US9452973B2

  公开（公告）日：2016-09-27