7-(phenylthio)-3,5,8,8a-tetrahydro-5-indolizinone | 1415683-64-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 7-(phenylthio)-3,5,8,8a-tetrahydro-5-indolizinone
• 英文别名: 7-phenylsulfanyl-8,8a-dihydro-3H-indolizin-5-one
• CAS: 1415683-64-5
• 化学式: C₁₄H₁₃NOS
• 分子量: 243.329
• InChiKey: FMRDUSXRFJMNSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-(phenylthio)-3,5,8,8a-tetrahydro-5-indolizinone 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 水 为溶剂， 以77%的产率得到7-(phenylsulfonyl)-3,5,8,8a-tetrahydro-5-indolizinone
  参考文献：
  名称：

  New synthesis and reactions of indolizidine 167E and indolizidine derivatives

  摘要：

  Two new methods of synthesizing indolizidines via ring-closing metathesis (RCM) have been developed. One method utilizes an alkene-isomerization, and the other method uses N-vinylation of an amide as the key step. Indolizidine 167E and many derivatives have also been synthesized. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.026
• 作为产物：
  描述：

  1-allyl-4-(phenylthio)-6-(E-1-propenyl)-1,2,5,6-tetrahydro-2-pyridinone 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以67%的产率得到7-(phenylthio)-3,5,8,8a-tetrahydro-5-indolizinone
  参考文献：
  名称：

  New synthesis and reactions of indolizidine 167E and indolizidine derivatives

  摘要：

  Two new methods of synthesizing indolizidines via ring-closing metathesis (RCM) have been developed. One method utilizes an alkene-isomerization, and the other method uses N-vinylation of an amide as the key step. Indolizidine 167E and many derivatives have also been synthesized. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.026

文献信息

• New synthesis and reactions of indolizidine 167E and indolizidine derivatives
  作者：Shang-Shing P. Chou、Shan-Lun Chiang、Guan-Lin Huang、Bi-Shan Chiang、Ya-Chien Yu

  DOI：10.1016/j.tet.2012.10.026

  日期：2013.1

  Two new methods of synthesizing indolizidines via ring-closing metathesis (RCM) have been developed. One method utilizes an alkene-isomerization, and the other method uses N-vinylation of an amide as the key step. Indolizidine 167E and many derivatives have also been synthesized. (C) 2012 Elsevier Ltd. All rights reserved.