3-(pyridine-2-yl)isoquinoline | 58814-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(pyridine-2-yl)isoquinoline
• 英文别名: 3-(pyridin-2-yl)isoquinoline；3-(2-pyridyl)isoquinoline；pyridylquinoline；3-pyridin-2-yl-isoquinoline；3-(2-pyridyl)-isoquinoline；3-(2-Pyridyl)isochinolin；3-pyridin-2-ylisoquinoline
• CAS: 58814-67-8
• 化学式: C₁₄H₁₀N₂
• 分子量: 206.247
• InChiKey: WTTNREGFXXNAIL-UHFFFAOYSA-N

物化性质

• 沸点：
  374.3±22.0 °C(Predicted)
• 密度：
  1.176±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  六氟磷酸钾 、 trans-bis((diphenylthio)ethane)dichlororuthenium(II) 、 3-(pyridine-2-yl)isoquinoline 以 not given 为溶剂， 以93%的产率得到[Ru(II)((diphenylthio)ethane)(pyridylquinoline)](PF6)2
  参考文献：
  名称：

  摘要：

  The complexation reaction of trans-[RuCl2(Dpte)(2)] (Dpte - (diphenylthio)ethane) with mixed diimine ligands 2,2'-bipyridine, pyridylquinoline, 4,6-dichloro-2-(2-pyridyl)pyrimidine, 4,6-dichloro-5-methyl-2-(2-pyridyl)pyrimidine, and 4,6-dichloro-5-phenyl-2-(2-pyridyl)pyrimidine produces new Ru(II) mixed-ligand complexes. These complexes exhibit maximum photo- and chemical stability and high absorptivity. The above complexes have been characterized using IR, H-1 and C-13 NMR, electronic absorption spectroscopy, and elemental analysis.

  DOI：

  10.1023/a:1021158931775
• 作为产物：
  描述：

  3-(1,2,4-Triazin-3-yl)isoquinoline 在 2,5-降冰片二烯 作用下， 以 xylene 为溶剂， 反应 5.0h， 以90.4%的产率得到3-(pyridine-2-yl)isoquinoline
  参考文献：
  名称：

  PROCESS FOR THE PRODUCTION OF 2-PYRIDYLPYRIDINE DERIVATIVES

  摘要：

  公开号：

  EP1186596B1

文献信息

• Manganese/cobalt-catalyzed oxidative C(sp³)–H/C(sp³)–H coupling: a route to α-tertiary β-arylethylamines
  作者：Meiling Tan、Kaizhi Li、Jiangliang Yin、Jingsong You

  DOI：10.1039/c7cc08512e

  日期：——

  An oxidative coupling reaction of an α-C(sp³)–H bond of amine with a benzylic C(sp³)–H bond provides diverse collections of α-tertiary β-arylethylamines.

  一种胺的α-C(sp3)-H键与苄基的C(sp3)-H键之间的氧化偶联反应可提供多样化的α-三级β-芳基乙胺集合。
• LIGHT INDUCED DRUG RELEASE
  申请人：Bonnet Sylvestre

  公开号：US20140148425A1

  公开（公告）日：2014-05-29

  Photosensitive compounds for use in a method of treating a disease or condition are described. The photosensitive compounds have the formula R—Y, wherein R is a ruthenium complex and Y is at least one sulphur-containing photoreleasable group, and the compounds comprise at least one ruthenium-sulphur bond; or a pharmaceutically acceptable salt, solvate, ester or amide, such that upon influence of visible or near infra-red light (400-1400 nm) in vivo, said at least one ruthenium-sulphur bond is broken, thereby generating a pharmacologically active compound.

  描述了用于治疗疾病或症状的一种方法中使用的光敏化合物。这些光敏化合物具有R—Y的化学式，其中R是一个钌配合物，Y是至少一个含硫光释放基团，这些化合物包括至少一个钌-硫键；或者是药用可接受的盐、溶剂合物、酯或酰胺，因此，在体内受到可见光或近红外光（400-1400纳米）的影响时，所述至少一个钌-硫键被断裂，从而产生一种药理活性化合物。
• Alkoxide-Catalyzed Hydrosilylation of Cyclic Imides to Isoquinolines via Tandem Reduction and Rearrangement
  作者：Xiaoyu Wu、Guangni Ding、Liqun Yang、Wenkui Lu、Wanfang Li、Zhaoguo Zhang、Xiaomin Xie

  DOI：10.1021/acs.orglett.8b02287

  日期：2018.9.21

  realized via tandem reduction and rearrangement. Using TMSOK as the catalyst and (EtO)2MeSiH as the reductant, a series of cyclic imides containing different functional groups were reduced to the corresponding 3-aryl isoquinolines in moderate to good yields. The scenario of the reaction pathway was supposed to involve the reduction of imides to ω-hydroxylactams, which underwent rearrangement in the presence

  通过串联还原和重排实现了醇盐催化的环状酰亚胺氢化成异喹啉。使用TMSOK作为催化剂，使用（EtO）2 MeSiH作为还原剂，将一系列包含不同官能团的环状酰亚胺以中等至良好的产率还原为相应的3-芳基异喹啉。该反应途径的场景被认为包括将酰亚胺还原为ω-羟基内酰胺，其在碱性催化剂的存在下进行重排，然后羰基还原，然后甲硅烷氧基消除。
• Process for the production of 2-pyridylpyridine derivatives
  申请人：Sankio Chemical Co., Ltd.

  公开号：US06504032B1

  公开（公告）日：2003-01-07

  A process for producing a 2-pyridylpyridine derivative usable as an intermediate for medicines or agricultural chemicals is provided, which does not require expensive metal catalysts, which does not cause environmental problems, and which can be conducted on an industiral scale. The process comprises the step (A) of producing an amidrazone compound from a cyano group-containing heterocyclic compound in water, the step (B) of producing a 1,2,4-triazine compound from the amidrazone compound in water, and the step (C) of producing a 2-pyridylpyridine derivative from the 1,2,4-triazine compound.

  提供一种用作药物或农药中间体的2-吡啶基吡啶衍生物的生产方法，该方法不需要昂贵的金属催化剂，不会造成环境问题，并且可以在工业规模上进行。该方法包括以下步骤：（A）在水中从含氰基的杂环化合物中产生酰肼化合物，（B）在水中从酰肼化合物中产生1,2,4-三嗪化合物，以及（C）从1,2,4-三嗪化合物中产生2-吡啶基吡啶衍生物。
• CYCLOMETALATED TRANSITION METAL COMPLEXES FOR MULTIPLEX ANALYTE DETECTION
  申请人：Berkelman Thomas R.

  公开号：US20100144046A1

  公开（公告）日：2010-06-10

  A complex containing a transition metal ion and a plurality of donor ligands each of which is fully coordinated to the transition metal ion and is either a nitrogen donor ligand or a cyclometalated donor ligand, such that at least one of the donor ligands is a cyclometalated donor ligand bears one or more reactive groups connected to at least one of the donor ligands through a linker that includes a chain of four or more atoms. The linker offers advantages that make the complex particularly effective in labeling biomolecules and in multiplex analyses.

  本文描述了一种包含过渡金属离子和多种供体配体的复合物，每个供体配体都与过渡金属离子完全配位，并且是氮供体配体或环金属供体配体，至少一个供体配体是带有一个或多个反应基团的环金属供体配体，该反应基团通过一个包含四个或更多原子的链连接到至少一个供体配体上。该链连接提供了优势，使得该复合物在标记生物分子和多重分析中特别有效。