(4-hydroxy-6-methyl-1,3-phenylene)bis(phenylmethanone) | 137937-48-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (4-hydroxy-6-methyl-1,3-phenylene)bis(phenylmethanone)
• 英文别名: (5-Benzoyl-4-hydroxy-2-methylphenyl)-phenylmethanone
• CAS: 137937-48-5
• 化学式: C₂₁H₁₆O₃
• 分子量: 316.356
• InChiKey: VLLCLLAUSBOVFK-UHFFFAOYSA-N

物化性质

• 沸点：
  491.7±45.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-hydroxy-2-methylbenzophenone benzoate 在 三氯化铝 作用下， 反应 2.0h， 以61%的产率得到(4-hydroxy-6-methyl-1,3-phenylene)bis(phenylmethanone)
  参考文献：
  名称：

  Martin, Robert; Lafrance, Jean Ronald; Demerseman, Pierre, Bulletin des Societes Chimiques Belges, 1991, vol. 100, # 7, p. 539 - 548

  摘要：

  DOI：

文献信息

• Synthesis of substituted phenols via 1,1-dichloro-2-nitroethene promoted condensation of carbonyl compounds with DMF
  作者：Fukai Wang、Wei Wu、Xiaoyong Xu、Xusheng Shao、Zhong Li

  DOI：10.1016/j.tetlet.2018.04.076

  日期：2018.6

  A novel and efficient metal-free synthesis of phenolic compounds was developed via coupling cyclization of DMF as a carbon source with active methylene compounds such as 1,3-dicarbonyl compounds with the assistance of 1,1-dichloro-2-nitroethene. The method we used was different from other traditional phenol functionalization methods. In the reaction, the 1,1-dichloro-2-nitroethene as a promoter which

  通过将作为碳源的DMF与活性亚甲基化合物（例如1,3-二羰基化合物）在1,1-二氯-2-硝基乙烯的辅助下偶联环化，开发了一种新颖，有效的无金属酚类化合物合成方法。我们使用的方法不同于其他传统的苯酚官能化方法。在反应中，1,1-二氯-2-硝基乙烯作为促进剂，这与我们先前对1,1-二氯-2-硝基乙烯的研究不同。该方法允许在温和的反应条件下以中等收率方便地构建酚类化合物。
• Palladium-catalyzed formation of phenolic compounds by reaction of carbonyl compounds with carbon dioxide
  作者：Qi Gao、Xian-chun Tan、Ying-ming Pan、Heng-shan Wang、Ying Liang

  DOI：10.1039/c2cc37194d

  日期：——

  The use of carbon dioxide as a renewable and environmentally friendly source of carbon is highly attractive. A novel and efficient protocol for the synthesis of phenolic compounds from carbonyl compounds and carbon dioxide in the presence of a catalytic amount of Pd(OAc)2 has been developed. This reaction is appealing for industries and is a tool for the sequestration of carbon dioxide.

  二氧化碳作为一种可再生且环保的碳源，具有极高的吸引力。在催化剂 Pd(OAc)2 的存在下，从羰基化合物和二氧化碳合成酚类化合物的新颖而高效的方案已经开发出来。这种反应对工业很有吸引力，也是二氧化碳封存的一种工具。
• Copper-catalyzed synthesis of phenolic compounds with DMSO as the methylene source
  作者：Run Luo、Lina Guo、Wenjie Liu、Shaohua Wang

  DOI：10.1080/00397911.2021.1902536

  日期：——

  application of DMSO as an ideal source of carbon is highly attractive. A simple and novel protocol has been developed for the synthesis of phenolic compounds via CuSO4·5H2O-catalyzed cyclization of 1,3-dicarbonyl compounds with DMSO. It was found that the unsymmetrical 1,3-dicarbonyl compounds always gave a mixture of two isomeric products. In addition, the deuterium-labeling experiments revealed that the C2

  摘要 DMSO作为理想的碳源的应用极具吸引力。已经开发了一种简单新颖的方案，用于通过DMSO通过CuSO 4 ·5H 2 O催化1,3-二羰基化合物的环化反应合成酚类化合物。发现不对称的1，3-二羰基化合物总是给出两种异构产物的混合物。另外，氘标记实验表明苯环中的C2是DMSO产生的。