1-<4-Amino-benzoyl>-guanidin | 3166-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-<4-Amino-benzoyl>-guanidin
• 英文别名: (4-amino-benzoyl)-guanidine；(4-Amino-benzoyl)-guanidin；4-amino-N-carbamimidoylbenzamide
• CAS: 3166-06-1
• 化学式: C₈H₁₀N₄O
• 分子量: 178.194
• InChiKey: CNRCFIFMZGXXRA-UHFFFAOYSA-N

物化性质

• 熔点：
  101-104 °C
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-<4-Amino-benzoyl>-guanidin 在 乙醇 、 镍 作用下， 生成 N-(4-amino-benzoyl)-N'-sulfanilyl-guanidine
  参考文献：
  名称：

  Cortisol secretion throughout the day, perceptions of the work environment, and negative affect

  摘要：

  The effects of explanatory variables derived from a work stress model (the effort-reward imbalance model) on salivary cortisol were assessed A multilevel analysis was used to distinguish the effects of single occasion and multiple occasion measurements of work stress and effect an cortisol. The single (or cross-sectional) factors include Effort-Reward imbalance (ERI), need for control negative affect, and other enduring factors (type of occupation, gender and smoking). The multiple occasion measurements include momentary negative mood, Momentary Demand-Satisfaction Ratio (MD-SR), sleep quality, work load (workday versus day off) at work (versus not being at the workplace). and lunch. The effect of time of day on cortisol was controlled for before the effects of these variables were determined.Momentary negative mood but not trait negative affect was positively associated with ambulatory measured cortisol. The variables from the work stress model-effort, reward need for control, and the multiple occasion measurements of demand arm satisfaction-did not affect cortisol. As could be expected, time of day had an effect on cortisol ,but a hypothesised interaction with momentary negative mood was not found. Additionally, the results show that the time course of cortisol differs between individuals and that the effect of sleep quality on cortisol can vary from person to person. This points to the necessity of continued efforts to single out sources of individual variability.The finding that variables derived from the effort-reward imbalance model are not related with cortisol does not support the hypothesis that ERI lends to short-term changes in cortisol, indicating no relation with hypothalamic-pituitary-adrenal (HPA) axis activity. On the other hand the present results invite further qualification of negative affect as a potential determinant of HPA activity at least, as far as can be deduced from cortisol measurements.

  DOI：

  10.1007/bf02895668
• 作为产物：
  描述：

  4-硝基苯甲酸丙酯 在 sodium ethanolate 、 镍 作用下， 生成 1-<4-Amino-benzoyl>-guanidin
  参考文献：
  名称：

  Optimism and depression as predictors of physical and mental health functioning: The normative aging study

  摘要：

  Dispositional optimism has been linked in previous studies to better health outcomes. We sought to examine the independent associations of dispositional optimism and depressive symptoms with physical and mental functioning in a cohort of healthy middle-aged and older men. The study was conducted among 659 subjects in the Veterans Administration (VA) Normative Aging Study. Dispositional optimism and depressive symptomatology were measured in 1991 and 1990, respectively, by the Life Orientation Test and the Center for Epidemiologic Studies-Depression Scale (CES-D). The dependent variables, functioning and well-being, were measured in 1992 by the Medical Outcomes Study Short-Form Health Survey (SF-36). In multivariate regression models, optimism was associated with higher levels of general health perceptions, vitality, and mental health, and lower levels of bodily pain, but not to physical functioning, social functioning, or role limitations due to physical or emotional problems. Depressive symptomatology was associated with reduced levels of functioning across all SF-36 domains. The findings for optimism and depression were statistically significant after mutual adjustment in multivariate regression models. Optimism and depression are independent predictors of functional status among aging men.

  DOI：

  10.1007/bf02895776

文献信息

• Aminosubstituierte Benzoylguanidine mit antiarrhythmischen Eigenschaften
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0556672B1

  公开（公告）日：1997-08-06
• 4-Amino-benzoylguanidin-Derivate
  申请人：MERCK PATENT GmbH

  公开号：EP0723963B1

  公开（公告）日：2001-06-13
• C-4' MODIFIED ADENOSINE KINASE INHIBITORS
  申请人：Gensia Sicor Inc.

  公开号：EP0832091B1

  公开（公告）日：2004-01-14
• US5739142A
  申请人：——

  公开号：US5739142A

  公开（公告）日：1998-04-14
• Optimism and depression as predictors of physical and mental health functioning: The normative aging study
  作者：Helen Achat、Ichiro Kawachi、Avron Spiro、Deborah A. DeMolles、David Sparrow

  DOI：10.1007/bf02895776

  日期：2000.6

  Dispositional optimism has been linked in previous studies to better health outcomes. We sought to examine the independent associations of dispositional optimism and depressive symptoms with physical and mental functioning in a cohort of healthy middle-aged and older men. The study was conducted among 659 subjects in the Veterans Administration (VA) Normative Aging Study. Dispositional optimism and depressive symptomatology were measured in 1991 and 1990, respectively, by the Life Orientation Test and the Center for Epidemiologic Studies-Depression Scale (CES-D). The dependent variables, functioning and well-being, were measured in 1992 by the Medical Outcomes Study Short-Form Health Survey (SF-36). In multivariate regression models, optimism was associated with higher levels of general health perceptions, vitality, and mental health, and lower levels of bodily pain, but not to physical functioning, social functioning, or role limitations due to physical or emotional problems. Depressive symptomatology was associated with reduced levels of functioning across all SF-36 domains. The findings for optimism and depression were statistically significant after mutual adjustment in multivariate regression models. Optimism and depression are independent predictors of functional status among aging men.