5-Oxaspiro[2.4]heptan-6-imine hydrobromide | 491572-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 5-Oxaspiro[2.4]heptan-6-imine hydrobromide
• 英文别名: 5-oxaspiro[2.4]heptan-6-imine;hydrobromide
• CAS: 491572-79-3
• 化学式: C6H10BrNO
• 分子量: 192.05
• InChiKey: YVXJXBKZADVHMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.74
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• PROCESS FOR THE PREPARATION OF 1-(MERCAPTOMETHYL)-CYCLOPROPANEACETIC ACID
  申请人：Delmar Chemicals Inc.

  公开号：EP1474386A1

  公开（公告）日：2004-11-10
• US6512140B1
  申请人：——

  公开号：US6512140B1

  公开（公告）日：2003-01-28
• [EN] PROCESS FOR THE PREPARATION OF 1-(MERCAPTOMETHYL)-CYCLOPROPANEACETIC ACID<br/>[FR] PROCESSUS DESTINE A LA PREPARATION D'ACIDE 1-(MERCAPTOMETHYL)-CYCLOPROPANE-ACETIQUE
  申请人：DELMAR CHEMICALS INC

  公开号：WO2003066582A1

  公开（公告）日：2003-08-14

  A process for the preparation of highly pure 1-(mercaptomethyl)-cyclopropaneacetic acid is described. Treatment of 1-(hydroxymethyl)-cyclopropaneacetonitrile with an acid provides the corresponding imino ester and/or halo-amide, which when reacted with thiourea provides the corresponding amide-isothiuronium salt. Hydrolysis of the amide-isothiuronium salt followed by an in situ oxidation allows the facile isolation and purification of 1-[1-(carboxymethyl)-cyclopropanemethyldisulfanylmethyl]-cyclopropaneacetic acid (also known as 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide). Reduction of the 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide under mild conditions provides the 1-(mercaptomethyl)-cyclopropaneacetic acid with high purity.