N'-(4-fluorobenzoyl)hydrazinecarbodithioic acid | 736084-51-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(4-fluorobenzoyl)hydrazinecarbodithioic acid
• 英文别名: [(4-Fluorobenzoyl)amino]carbamodithioic acid；[(4-fluorobenzoyl)amino]carbamodithioic acid
• CAS: 736084-51-8
• 化学式: C₈H₇FN₂OS₂
• 分子量: 230.287
• InChiKey: YYZNHYGLEWIYSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N'-(4-fluorobenzoyl)hydrazinecarbodithioic acid 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 3-(4-fluorophenyl)-6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
  参考文献：
  名称：

  Nadkarni; Kamat; Khadse, Arzneimittel-Forschung/Drug Research, 2001, vol. 51, # 7, p. 569 - 573

  摘要：

  DOI：
• 作为产物：
  描述：

  对氟苯甲酸甲酯 在 氢氧化钾 、 一水合肼 作用下， 以 乙醇 为溶剂， 生成 N'-(4-fluorobenzoyl)hydrazinecarbodithioic acid
  参考文献：
  名称：

  Nadkarni; Kamat; Khadse, Arzneimittel-Forschung/Drug Research, 2001, vol. 51, # 7, p. 569 - 573

  摘要：

  DOI：

文献信息

• A novel 5-mercapto triazole Schiff base as a selective chromogenic chemosensor for Cu2+
  作者：Ming-Xia Liu、Tai-Bao Wei、Qi Lin、You-Ming Zhang

  DOI：10.1016/j.saa.2011.05.068

  日期：2011.9

  A novel colorimetric cation sensor bearing phenol, thiol and HC=N groups was designed and synthesized. In a DMSO/H2O (9:1, v/v) solution, the sensor exhibited highly selective recognition of Cu2+ among a range of metal ions tested. In the presence of Cu2+, solutions of the sensor underwent a dramatic color change from colorless to yellow, while the presence of other metal cations such as Zn2+, Pb2+, Cd2+, Ni2+, Co2+, Fe3+, Hg2+, Ag+ and Ca2+ had no effect on the color. The detection limit of the sensor toward Cu2+ is 8.0 x 10(-7) M and an association constant K-a of 4.3 x 10(5) M-1 was measured. The sensing of Cu2+ by this sensor was found to be reversible, with the Cu2+-incluced color being lost upon addition of EDTA. (C) 2011 Elsevier B.V. All rights reserved.
• Synthesis and Evaluation of Antiphlogistic Activity of Some New 4-Fluorophenyltriazolothiadiazines
  作者：P. D. Bangre、N. A. Karande、L. G. Rathi、D. J. Singhavi、R. O. Ganjiwale、A. Nagar、A. R. Bendale、K. R. Danao

  DOI：10.59467/ijhc.2024.34.1

  日期：2024.3

  The reaction between 4-fluorobenzoic acid hydrazide (1) and carbon disulfide in the existence of alcoholic potassium hydroxide yielded N?-(4-fluoro-benzoyl)-hydrazinecarbodithioic acid (2). Subsequently, product 2 on reaction with an aqueous solution of hydrazine hydrate led to the formation of compound 3. The condensation of compound 3 with various substituted ?-bromoacetophenones in ethanol furnished the targeted triazolothiadiazines, bearing a 4-fluorophenyl moiety (4a-l). Subsequently, a comprehensive evaluation of the antiphlogistic potential of the synthesized molecules 4a-l was conducted. This assessment was completed using albino Wistar rats that had their paws swollen with carrageenan. Compounds 4l and 4b demonstrated significant (P < 0.01) antiphlogistic activity. Furthermore, compounds 4d, 4f, and 4k exhibited noteworthy antiphlogistic effects (P < 0.05), comparable to the standard drug indomethacin. This study sheds light on the antiphlogistic properties of these compounds and holds promise for further research in this area. . KEYWORDS :Antiphlogistic, Anti-inflammatory, 4-Fluorophenyl, Triazole, Thiadiazine.
• Nadkarni; Kamat; Khadse, Arzneimittel-Forschung/Drug Research, 2001, vol. 51, # 7, p. 569 - 573
  作者：Nadkarni、Kamat、Khadse

  DOI：——

  日期：——