[(Z)-2-benzylsulfanyl-1-butyltellanylethenyl]benzene | 898562-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(Z)-2-benzylsulfanyl-1-butyltellanylethenyl]benzene
• CAS: 898562-32-8
• 化学式: C₁₉H₂₂STe
• 分子量: 410.05
• InChiKey: YCXTXLHFTDKZAZ-MNDPQUGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.84
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [(Z)-2-benzylsulfanyl-1-butyltellanylethenyl]benzene 、 (碘乙炔基)苯 在 copper(l) iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以54%的产率得到
  参考文献：
  名称：

  Csp3-tellurium copper cross-coupling: synthesis of alkynyl tellurides a novel class of antidepressive-like compounds

  摘要：

  We present here the results on the synthesis of functionalized alkynyl tellurides using the reaction of vinyl, alkynyl, and aryl tellurides with several alkynyl iodides catalyzed by copper iodide. The reaction proceeded cleanly under mild reaction conditions, at room temperature, in the absence of base and ligand giving alkynyl tellurides in acceptable yields. The obtained compounds 3a-c and 3m-o were screened for antidepressive-like activity using the tail Suspension test (TST) in mice. Compounds 3a-c and 3m-o administered at 10 mg/kg by oral route produced a significant antidepressant-like effect on the TST in mice. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.024

文献信息

• Csp3-tellurium copper cross-coupling: synthesis of alkynyl tellurides a novel class of antidepressive-like compounds
  作者：Afamefuna Elvis Okoronkwo、Benhur Godoi、Ricardo Frederico Schumacher、José Sebastião Santos Neto、Cristiane Luchese、Marina Prigol、Cristina Wayne Nogueira、Gilson Zeni

  DOI：10.1016/j.tetlet.2008.12.024

  日期：2009.2

  We present here the results on the synthesis of functionalized alkynyl tellurides using the reaction of vinyl, alkynyl, and aryl tellurides with several alkynyl iodides catalyzed by copper iodide. The reaction proceeded cleanly under mild reaction conditions, at room temperature, in the absence of base and ligand giving alkynyl tellurides in acceptable yields. The obtained compounds 3a-c and 3m-o were screened for antidepressive-like activity using the tail Suspension test (TST) in mice. Compounds 3a-c and 3m-o administered at 10 mg/kg by oral route produced a significant antidepressant-like effect on the TST in mice. (C) 2008 Elsevier Ltd. All rights reserved.