N,N'-((3-bromophenyl)methylene)dibenzamide | 312537-02-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-((3-bromophenyl)methylene)dibenzamide
• 英文别名: N-[benzamido-(3-bromophenyl)methyl]benzamide
• CAS: 312537-02-3
• 化学式: C₂₁H₁₇BrN₂O₂
• 分子量: 409.282
• InChiKey: YESRWMJWSQXEDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  间溴苯甲醛 、 苯甲酰胺 在 silica-bonded S-sullfonic acid nanoparticles 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以93%的产率得到N,N'-((3-bromophenyl)methylene)dibenzamide
  参考文献：
  名称：

  二氧化硅键合的 S-磺酸纳米粒子催化醛和酰胺有效合成对称双酰胺

  摘要：

  摘要 二氧化硅键合的 S-磺酸纳米粒子 (SBSANPs) 很容易由二氧化硅纳米粒子合成，并被证明是合成对称 N,N'-亚烷基双酰胺的有效催化剂。在催化剂存在下醛和酰胺的反应以良好至极好的产率提供相应的双酰胺。广泛的底物范围表明该方法具有普遍适用性。催化剂的可重复使用性、简单的后处理程序和较短的反应时间是该协议的其他优点。补充材料可用于本文。访问出版商的 Synthetic Communications ® 在线版以查看免费的补充文件。图形概要

  DOI：

  10.1080/00397911.2012.709573

文献信息

• A convenient synthesis of bisamides with BF3 etherate as catalyst
  作者：Yi Zhang、Zhihao Zhong、Yingmei Han、Ruirui Han、Xu Cheng

  DOI：10.1016/j.tet.2013.11.017

  日期：2013.12

  A convenient synthesis of bisamide from aldehyde and amide with BF3 etherate as catalyst was reported. Both aryl and aliphatic bisamides could be prepared with this procedure in high yield at room temperature and the catalyst loading as low as 0.5 mol % was achieved. Fine-tuned solvent was utilized for both rapid conversion and simple isolation. Two CB2 receptor inverse agonists were synthesized with

  从醛和酰胺与BF双酰胺的一种方便的合成3作为报道醚合物催化剂。可以通过该方法在室温下以高收率制备芳基和脂族双酰胺，并且催化剂的负载量低至0.5 mol％。微调的溶剂可用于快速转化和简单分离。两个CB 2受体反向激动剂，用该协议以高收率合成。
• Synthesis of symmetrical N,N′-alkylidene bis-amides catalyzed by silica coated magnetic NiFe₂O₄ nanoparticle supported polyphosphoric acid (NiFe₂O₄@SiO₂-PPA) and its application toward silver nanoparticle synthesis for electrochemical detection of glucose
  作者：Behrooz Maleki、Mehdi Baghayeri

  DOI：10.1039/c5ra16481h

  日期：——

  For the first time, a new and facile Ag@PM-b-B nanocomposite electrochemical sensor was successfully developed for the detection of glucose. Also, the magnetically recoverable catalyst was easily recycled at least ten times without significant loss of catalytic activity.

  首次成功开发了一种新颖且便捷的Ag@PM-b-B纳米复合电化学传感器，用于检测葡萄糖。此外，这种具有磁性可回收性的催化剂可轻松回收至少十次，而且催化活性几乎没有明显损失。
• <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-Tetramethylethylene-diaminium-<i>N</i>,<i>N</i>′-disulfonic acid trifluoroacetate and pyridinium-<i>N</i>-sulfonic acid hydrogen sulfate as highly effective dual-functional catalysts for the preparation of <i>N</i>,<i>N</i>′-alkylidene bisamides
  作者：Zahra Kordrostami、Abdolkarim Zare、Mostafa Karami

  DOI：10.1515/znb-2019-0064

  日期：2019.9.25

  In this research, Brønsted-acidic ionic liquids N,N,N′,N′-tetramethylethylene-diaminium-N,N′-disulfonic acid trifluoroacetate ([TMEDSA][TFA]₂) and pyridinium-N-sulfonic acid hydrogen sulfate ([Py-SO₃H][HSO₄]) have been introduced as dual-functional catalysts for the green, simple and effective preparation of N,N′-alkylidene bisamides by the reaction of primary amides (2 eq.) with arylaldehydes (1 eq.) under solvent-free conditions. The reaction results and conditions of the catalysts have been compared with the previously reported ones. [TMEDSA][TFA]₂ and [Py-SO₃H][HSO₄] were superior to the previously reported catalysts in terms of two or more of these factors: reaction times (10–45 min), yields (86–98%), temperature and the reaction conditions. Additionally, a plausible and attractive mechanism based on dual functionality of the catalysts has been proposed.

  在这项研究中，Brønsted酸性离子液体N,N,N′,N′-四甲基乙二胺-N,N′-二磺酸三氟乙酸酯([TMEDSA][TFA]2)和吡啶-N-磺酸氢硫酸盐([Py-SO3H][HSO4])被引入作为双功能催化剂，用于在无溶剂条件下通过一次酰胺(2当量)与芳基醛(1当量)的反应绿色、简单和有效地制备N,N′-烷基亚胺。与先前报道的催化剂相比，这些催化剂的反应结果和条件进行了比较。[TMEDSA][TFA]2和[Py-SO3H][HSO4]在反应时间(10-45分钟)、产率(86-98%)、温度和反应条件等两个或更多因素方面优于先前报道的催化剂。此外，提出了基于催化剂双重功能性的可能且有吸引力的机制。
• Graphene oxide anchored with sulfonic acid-functionalized glycerin: production, characterization and catalytic performance for the synthesis of N,N′-alkylidene bisamides
  作者：Seham Naeim-Fallahiyeh、Esmael Rostami、Habibeh Golchaman、Soheila Kaman-Torki

  DOI：10.1007/s11164-020-04197-6

  日期：2020.9

  Abstract A novel nanosheet-structured material, namely graphene oxide anchored with sulfonic acid-functionalized glycerin (GO@Gl-SO3H), was prepared and characterized by FTIR, EDS, FESEM, TEM and XRD analyses. Afterward, its catalytic performance was examined for the synthesis of N,N′-alkylidene bisamides through the reaction of benzamide (2 eq.) and arylaldehydes (1 eq.) under solvent-free conditions

  摘要 制备了一种新型的纳米片结构材料，即以磺酸官能化的甘油锚固的氧化石墨烯（GO @ Gl-SO 3 H），并通过FTIR，EDS，FESEM，TEM和XRD分析对其进行了表征。然后，在无溶剂条件下，通过苯甲酰胺（2eq。）和芳醛（1eq。）的反应，研究了其催化性能，以合成N，N'-亚烷基双酰胺。GO @ G1-SO 3 H是用于该反应的高效催化剂，并以高收率和较短的反应时间提供产物。 图形摘要
• Immobilization of dihydrogen phosphate onto rice husk ash as a highly efficient and green catalyst for the synthesis of symmetrical N,N′-alkylidene bisamides
  作者：Hamid Reza Saadati-Moshtaghin

  DOI：10.1007/s11164-019-03779-3

  日期：2019.5

  The preparation and characterization of an environmentally-benign and low-cost catalyst consisting of KH2PO4 supported on silica from rice husk ash is reported. The prepared catalyst was characterized by FT-IR spectroscopy, field emission scanning electron microscopy, powder X-ray diffraction and inductively coupled plasma. The synthesized nanocomposite exhibited an excellent catalytic efficiency in

  报道了由稻壳灰制备负载在二氧化硅上的KH 2 PO 4组成的对环境无害且低成本的催化剂。通过FT-IR光谱，场发射扫描电子显微镜，粉末X射线衍射和电感耦合等离子体对所制备的催化剂进行了表征。合成的纳米复合材料在无溶剂条件下制备对称的 N ， N'-亚 烷基双酰胺的缩合反应中具有优异的催化效率 。