3-methyl-6,7-dihydro-5H-thiazolo<3,2-a>pyrimidine | 63821-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-methyl-6,7-dihydro-5H-thiazolo<3,2-a>pyrimidine
• 英文别名: 3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine；3-Methyl-6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine；NoName_3304
• CAS: 63821-41-0
• 化学式: C₇H₁₀N₂S
• mdl: MFCD27926758
• 分子量: 154.236
• InChiKey: CSLUAIAPONZAKA-UHFFFAOYSA-N

物化性质

• 沸点：
  249.8±23.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-4-甲基噻唑 、 1,3-二氯丙烷 生成 3-methyl-6,7-dihydro-5H-thiazolo<3,2-a>pyrimidine
  参考文献：
  名称：

  Issa,I.M. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1977, vol. 15, p. 356 - 358

  摘要：

  DOI：

文献信息

• Thiazoline derivative and use of the same
  申请人：Kubo Keiji

  公开号：US20070010528A1

  公开（公告）日：2007-01-11

  A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X′ is a bond or —N(R 5 )—; Y is a divalent hydrocarbon group which may be substituted; Y′ is a bond or —C(═O)—; ring A is a nitrogen-containing heterocycle which may be substituted; Z 1 and Z 3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z 2 is a bond or —N(R 6 )—; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

  提供一种由式（I）表示的噻唑啉衍生物：其中R是环烃基，可以被取代，或者是可以被取代的杂环基; X是键或二价链烃基，可以被取代; X'是键或-N(R5)-; Y是二价烃基，可以被取代; Y'是键或-C(═O)-; 环A是含氮杂环，可以被取代; Z1和Z3各自独立地是键或二价链烃基，可以被取代; Z2是键或-N(R6)-; B是下式表示的基团：该化合物可用作治疗血栓症的药物。
• THIAZOLINE DERIVATIVE AND USE OF THE SAME
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1669352A1

  公开（公告）日：2006-06-14

  A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X' is a bond or -N(R5)-; Y is a divalent hydrocarbon group which may be substituted; Y' is a bond or -C(=O)-; ring A is a nitrogen-containing heterocycle which may be substituted; Z1 and Z3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z2 is a bond or -N(R6)-; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

  式 (I) 所代表的噻唑啉衍生物： 其中 R 是可被取代的环烃基或可被取代的杂环基；X 是键或可被取代的二价链烃基；X'是键或-N(R5)-；Y 是可被取代的二价烃基；Y'是键或-C(=O)-； 环 A 是可被取代的含氮杂环； Z1 和 Z3 各自独立地是键或可被取代的二价链烃基； Z2 是键或-N(R6)-； 以及 B 是由式表示的基团： 本发明提供了一种可作为血栓形成治疗药物的药物。
• Chadha,V.K. et al., Indian Journal of Chemistry, 1971, vol. 9, p. 1216 - 1219
  作者：Chadha,V.K. et al.

  DOI：——

  日期：——
• US7534887B2
  申请人：——

  公开号：US7534887B2

  公开（公告）日：2009-05-19
• Issa,I.M. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1977, vol. 15, p. 356 - 358
  作者：Issa,I.M. et al.

  DOI：——

  日期：——