4-(2,4-dichlorophenyl)-N-phenylthiazol-2-amine | 402945-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,4-dichlorophenyl)-N-phenylthiazol-2-amine
• 英文别名: 4-(2,4-dichlorophenyl)-N-phenyl-1,3-thiazol-2-amine
• CAS: 402945-32-8
• 化学式: C₁₅H₁₀Cl₂N₂S
• 分子量: 321.23
• InChiKey: XGEGKXDVDOLOIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯基硫脲 、 2,2',4'-三氯苯乙酮 以 乙二醇 为溶剂， 反应 0.58h， 以94%的产率得到4-(2,4-dichlorophenyl)-N-phenylthiazol-2-amine
  参考文献：
  名称：

  Efficient and Expeditious Synthesis of Di- and Trisubstituted Thiazoles in PEG Under Catalyst-Free Conditions

  摘要：

  An efficient and expeditious catalyst-free protocol was developed for the construction of di- and trisubstituted thiazoles from -haloketones and thioureas/thioamides in PEG. The reaction was carried out at ambient temperature, and the products were obtained in excellent isolated yields (91-98%). Additionally, PEG could be recovered easily and was reused without evident loss in activity.

  DOI：

  10.1080/00397910802691874

文献信息

• Aryliodoazide Synthons: A Different Approach for Diversified Synthesis of 2-Aminothiazole, 1,3-Thiazole, and 1,3-Selenazole Scaffolds
  作者：Sahar Majnooni、Joseph Duffield、Jessica Price、Ahmad Reza Khosropour、Hassan Zali-Boeini、Hudson Beyzavi

  DOI：10.1021/acscombsci.9b00045

  日期：2019.7.8

  Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational

  已经建立了几种直接且实用的方法来从芳基碘化物构建 2-氨基噻唑、1,3-噻唑和 1,3-硒唑。这些策略成功地使用了广泛的取代硫代酰胺及其衍生物，产生了以令人满意的产率获得的五元杂环。这些协议的独特之处在于操作简单和高度官能团耐受性，这使其成为制备各种 2-氨基噻唑、1,3-噻唑和 1,3-硒唑库的方便实用的途径。
• Efficient and Expeditious Synthesis of Di- and Trisubstituted Thiazoles in PEG Under Catalyst-Free Conditions
  作者：Dongjian Zhu、Jiuxi Chen、Huilong Xiao、Miaochang Liu、Jinchang Ding、Huayue Wu

  DOI：10.1080/00397910802691874

  日期：2009.7.21

  An efficient and expeditious catalyst-free protocol was developed for the construction of di- and trisubstituted thiazoles from -haloketones and thioureas/thioamides in PEG. The reaction was carried out at ambient temperature, and the products were obtained in excellent isolated yields (91-98%). Additionally, PEG could be recovered easily and was reused without evident loss in activity.