4-[[Amino(anilino)methylidene]amino]benzoic acid | 108787-57-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[Amino(anilino)methylidene]amino]benzoic acid
• CAS: 108787-57-1
• 化学式: C₁₄H₁₃N₃O₂
• 分子量: 255.276
• InChiKey: SHQODGUVJNJQJI-UHFFFAOYSA-N

物化性质

• 沸点：
  423.4±47.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯基硫脲 在 过氧乙酸 、 potassium carbonate 作用下， 以 甲醇 、 水 为溶剂， 反应 24.0h， 生成 4-[[Amino(anilino)methylidene]amino]benzoic acid
  参考文献：
  名称：

  A Facile Conversion of Amino Acids to Guanidino Acids

  摘要：

  据报道，氨基酸通过氨基酸亚氨甲磺酸（2a-c）的作用转化为胍基酸。化合物2a-c是通过相应硫脲的过乙酸氧化合成的。

  DOI：

  10.1055/s-1986-31777

文献信息

• Methods and systems for the delivery of a therapeutic agent
  申请人：HANANJA EHF

  公开号：US10052333B2

  公开（公告）日：2018-08-21

  The present invention provides a liquid pharmaceutical composition comprising a therapeutic agent and an alkoxy-polyethylene glycol, for example, methoxy-polyethylene glycol, for administration of the therapeutic agent to the mammal. The compositions can be applied to a membrane, for example, a nasal membrane during intranasal administration. The invention also provides methods of administering such compositions to a mammal.

  本发明提供了一种由治疗剂和烷氧基聚乙二醇（例如甲氧基聚乙二醇）组成的液体药物组合物，用于向哺乳动物施用治疗剂。在鼻内给药过程中，这些组合物可以涂抹在膜上，例如鼻膜上。本发明还提供了向哺乳动物施用这种组合物的方法。
• A PHARMACEUTICAL PREPARATION CONTAINING N-GLYCOFUROLS AND N-ETHYLENE GLYCOLS
  申请人：BECHGAARD INTERNATIONAL RESEARCH AND DEVELOPMENT A/S

  公开号：EP0532546B1

  公开（公告）日：1998-03-18
• METHODS AND COMPOSITIONS FOR THE DELIVERY OF A THERAPEUTIC AGENT
  申请人：Hananja Ehf

  公开号：EP2121025B1

  公开（公告）日：2016-11-02
• Methods and Compositions for the Delivery of a Therapeutic Agent
  申请人：Gizurarson Sveinbjorn

  公开号：US20080275030A1

  公开（公告）日：2008-11-06

  The present invention provides a liquid pharmaceutical composition comprising a therapeutic agent and an alkoxy-polyethylene glycol, for example, methoxy-polyethylene glycol, for administration of the therapeutic agent to the mammal. The compositions can be applied to a membrane, for example, a nasal membrane during intranasal administration. The invention also provides methods of administering such compositions to a mammal.
• ANTI-RESORPTIVE BONE CEMENTS AND ALLOGENEIC, AUTOGRAFIC, AND XENOGRAFIC BONE GRAFTS
  申请人：Healey John H.

  公开号：US20080286377A1

  公开（公告）日：2008-11-20

  Anti-resorptive bone cements, comprising an anti-resorptive amount of one or more anti-resorptive agents, preferably the anti-resorptive agent is a bisphosphonate. The anti-resorptive bone cements are useful for reducing bone voids and bonding prosthetic devices to bone. The invention also relates to anti-resorptive allogeneic, autografic, and xenografic bone grafts, which bone grafts comprise an anti-resorptive amount of an anti-resorptive agent such as a bisphosphonate. The anti-resorptive bone grafts are useful for reconstructive bone surgery.