2-(Fluoromethyl)phenol | 62037-87-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(Fluoromethyl)phenol
• CAS: 62037-87-0
• 化学式: C₇H₇FO
• 分子量: 126.13
• InChiKey: AYHHDHPNVPMCIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase
  申请人：Forum Pharmaceuticals, Inc.

  公开号：US20170000749A1

  公开（公告）日：2017-01-05

  This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

  这份披露涉及用于抑制组蛋白去乙酰化酶和治疗认知障碍或缺陷的化合物。更具体地，该披露提供了公式（I）的化合物 其中 Q、J、L和Z如规范中所定义。
• Separation of amine from a phenolic compound
  申请人：Renner A. Carl

  公开号：US20050080294A1

  公开（公告）日：2005-04-14

  A process comprises contacting a product mixture with a base, optionally in the presence of a polyhydric alcohol, to produce a base-treated mixture and distilling the base-treated mixture in which the product mixture comprises an aromatic amine and a phenolic compound.

  一个过程包括将产品混合物与碱接触，可选地在多元醇的存在下，以产生经碱处理的混合物，并蒸馏经碱处理的混合物，其中产品混合物包括芳香胺和酚化合物。
• Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
  申请人：Chao J. Hannguang

  公开号：US20050267119A1

  公开（公告）日：2005-12-01

  The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y 1 receptor activity.

  本发明提供了新型吡啶基或苯基脲及其类似物，它们是人类P2Y1受体的选择性抑制剂。本发明还提供了各种相应的制药组合物和调节P2Y1受体活性的治疗疾病的方法。
• Method for producing an olefin type copolymer having a cyclic structure
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20020058767A1

  公开（公告）日：2002-05-16

  A method for producing an olefin type copolymer having a cyclic structure, which comprises copolymerizing ethylene (M1) and dicyclopentadiene or tricyclopentadiene (M2), and, as optionally introduced, a cyclic olefin (M3), wherein, as a catalyst, a catalyst comprising a metallocene compound (A) of the following formula [1]: H 2 C(R′ m CP)(R″ n Cp)Mx 2 [1] wherein M is zirconium or hafnium, Cp is a group having a cyclopentadienyl skeleton, each of R′ and R″ is a hydrocarbon group having 1 to 10 carbon atoms, each of two X's which may be the same or different from each other, is a halogen atom, a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms, a halogenated hydrocarbon group, an alkylamino group, an alkoxy group, an aryloxy group of the formula —O—Ar—Y p (wherein Ar is an aromatic ring, Y is a halogen atom, a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms, a halogenated hydrocarbon group, an alkoxy group, an alkylamino group, a cyano group or a nitro group, and p is an integer of from 1 to 5), a thioalkyl group, or a thioaryl group of the formula —S—Ar—Y p (wherein Ar, Y and p are as defined above), and each of m and n is an integer of from 0 to 4, provided that m and n are not equal, and m+n is an integer of from 3 to 6, and an aluminoxane (B), is used.

  一种制备具有环状结构的烯烃共聚物的方法，包括共聚乙烯（M1）和二环戊二烯或三环戊二烯（M2），以及作为可选引入的环状烯烃（M3），其中，作为催化剂使用以下式子（1）的金属茂化合物（A）：H2C(R′mCP)(R″nCp)Mx2（1），其中M为锆或铪，Cp为具有环戊二烯基骨架的基团，R′和R″各自为具有1至10个碳原子的碳氢基团，两个X可以相同也可以不同，是卤素原子、氢原子、具有1至20个碳原子的碳氢基团、卤代碳氢基团、烷基氨基基团、烷氧基、苯氧基（式中Ar为芳香环，Y为卤素原子、氢原子、具有1至20个碳原子的碳氢基团、卤代碳氢基团、烷氧基、烷基氨基基团、氰基或硝基，p为1至5的整数），硫代烷基团或硫代芳基团（式中Ar、Y和p如上所述），m和n各自为0至4的整数，但m和n不相等，且m+n为3至6的整数，并使用铝烷氧化物（B）。
• UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS
  申请人：Chao Hannguang J.

  公开号：US20080280905A1

  公开（公告）日：2008-11-13

  The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y 1 receptor activity.

  本发明提供了新型吡啶基或苯基脲及其类似物，它们是选择性的人类P2Y1受体抑制剂。本发明还提供了各种该类药物组成物和调节P2Y1受体活性以治疗对其反应的疾病的方法。