3-(2,2,3,3,4,4,5,5-Octafluoropentyloxy)-1,2-propanediol | 25385-69-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 3-(2,2,3,3,4,4,5,5-Octafluoropentyloxy)-1,2-propanediol
• 英文别名: 3-(2,2,3,3,4,4,5,5-octafluoropentoxy)propane-1,2-diol
• CAS: 25385-69-7
• 化学式: C₈H₁₀F₈O₃
• 分子量: 306.153
• InChiKey: XQNPGKQYINWYIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2,2,3,3,4,4,5,5-八氟-1-戊醇 在 盐酸 、 sodium 作用下， 以 甲醇 为溶剂， 反应 28.0h， 生成 3-(2,2,3,3,4,4,5,5-Octafluoropentyloxy)-1,2-propanediol
  参考文献：
  名称：

  Fluoroalkyl derivatives of protected glycerol by nucleophilic substitution. Fluorine-containing amphiphilic mono- and bis-methacrylates

  摘要：

  The tosylate of protected glycerol (solketal, 4-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolane) was fluoroalkylated by a nucleophilic substitution reaction with sodium polyfluoroalkoxides. On deprotection, 3-O-fluoroalkylated glycerol was obtained which was converted to mono-and bis-methacrylates; analogous methacrylate derivatives were prepared from 3,3,4,5,5,5-hexafluoro-pentane-1,2-diol. (C) 1997 Elsevier Science S.A.

  DOI：

  10.1016/s0022-1139(97)00063-8

文献信息

• Solov'ev, D. V.; Kolomenskaya, L. V.; Rodin, A. A., Journal of general chemistry of the USSR, 1991, vol. 61, # 3.2, p. 611 - 615
  作者：Solov'ev, D. V.、Kolomenskaya, L. V.、Rodin, A. A.、Zenkevich, I. G.、Lavrent'ev, A. N.

  DOI：——

  日期：——
• SOLOVEV, D. V.;KOLOMENSKAYA, L. V.;RODIN, A. A.;ZENKEVICH, I. G.;LAVRENTE+, ZH. OBSHCH. XIMII, 61,(1991) N, S. 673-678
  作者：SOLOVEV, D. V.、KOLOMENSKAYA, L. V.、RODIN, A. A.、ZENKEVICH, I. G.、LAVRENTE+

  DOI：——

  日期：——
• Fluoroalkyl derivatives of protected glycerol by nucleophilic substitution. Fluorine-containing amphiphilic mono- and bis-methacrylates
  作者：Jaroslav Kvíčala、Bohumil Dolenský、Oldřich Paleta

  DOI：10.1016/s0022-1139(97)00063-8

  日期：1997.10

  The tosylate of protected glycerol (solketal, 4-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolane) was fluoroalkylated by a nucleophilic substitution reaction with sodium polyfluoroalkoxides. On deprotection, 3-O-fluoroalkylated glycerol was obtained which was converted to mono-and bis-methacrylates; analogous methacrylate derivatives were prepared from 3,3,4,5,5,5-hexafluoro-pentane-1,2-diol. (C) 1997 Elsevier Science S.A.