4-methyl-N-[morpholino(phenyl)methylene]benzenesulfonamide | 17260-48-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-[morpholino(phenyl)methylene]benzenesulfonamide
• 英文别名: 4-methyl-N-(morpholino(phenyl)methylene)benzensulfonamide；4-[N-(toluene-4-sulfonyl)-benzimidoyl]-morpholine；Morpholine, 4-[[[(4-methylphenyl)sulfonyl]imino]phenylmethyl]-；4-methyl-N-[morpholin-4-yl(phenyl)methylidene]benzenesulfonamide
• CAS: 17260-48-9
• 化学式: C₁₈H₂₀N₂O₃S
• mdl: MFCD01108122
• 分子量: 344.434
• InChiKey: CYMNENNJRJQNSV-UHFFFAOYSA-N

物化性质

• 熔点：
  164-166 °C
• 沸点：
  508.8±60.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲醛 在 sulfur 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 4-methyl-N-[morpholino(phenyl)methylene]benzenesulfonamide
  参考文献：
  名称：

  Zinc Chloride Catalyzed Ring Opening of N-Arylsulfonyl Aziridines by Thioamides: A New Approach to the Synthesis of Amidines

  摘要：

  The first zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides is described. Various thioamides were reacted with N-arylsulfonyl aziridines in the presence of a catalytic amount of dry zinc chloride to provide the corresponding N-arylsulfonyl amidine derivatives with good to excellent yields.

  DOI：

  10.1055/s-0034-1378376

文献信息

• Facile Synthesis of Sulfonyl Amidines and β-Amino Sulfonyl Enamines under Transition-Metal-Free Conditions
  作者：Baohua Chen、Tingting Gao、Mingming Zhao、Xu Meng、Chuanbin Li

  DOI：10.1055/s-0030-1260548

  日期：2011.6

  Treatment of enamine and azide resulted in the formation of either sulfonyl amidine or β-amino sulfonyl enamine derivative in moderate to good yields. The reaction could proceed under catalyst-free conditions.

  烯胺和叠氮化物经处理后可生成磺酰基脒或 δ-氨基磺酰基烯胺衍生物，产率为中等到良好。反应可在无催化剂条件下进行。
• v-Triazolines—VI
  作者：Piero Dalla Croce、Riccardo Stradi

  DOI：10.1016/0040-4020(77)80036-7

  日期：1977.1
• Zinc Chloride Catalyzed Ring Opening of N-Arylsulfonyl Aziridines by Thioamides: A New Approach to the Synthesis of Amidines
  作者：Hassan Zali-Boeini、Khadijeh Hajibabaei

  DOI：10.1055/s-0034-1378376

  日期：——

  The first zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides is described. Various thioamides were reacted with N-arylsulfonyl aziridines in the presence of a catalytic amount of dry zinc chloride to provide the corresponding N-arylsulfonyl amidine derivatives with good to excellent yields.