2-(2,6-dimethoxypyridin-3-yl)isoindoline-1,3-dione | 848827-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2,6-dimethoxypyridin-3-yl)isoindoline-1,3-dione
• 英文别名: 2,6-Dimethoxy-3-phthalimidopyridine；2-(2,6-dimethoxypyridin-3-yl)isoindole-1,3-dione
• CAS: 848827-76-9
• 化学式: C₁₅H₁₂N₂O₄
• 分子量: 284.271
• InChiKey: MVLBQYGEKYUYHL-UHFFFAOYSA-N

物化性质

• 沸点：
  465.2±55.0 °C(Predicted)
• 密度：
  1.366±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2,6-dimethoxypyridin-3-yl)isoindoline-1,3-dione 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 54.0h， 以71%的产率得到1,3-dioxo-2-(2,6-dihydroxypyridin-3-yl)-isoindoline hydrobromide
  参考文献：
  名称：

  [EN] THALIDOMIDE ANALOGS AS TNF-ALPHA MODULATORS
  [FR] ANALOGUES DU THALIDOMIDE

  摘要：

  公开号：

  WO2005028436A3
• 作为产物：
  描述：

  N-羟基邻苯二甲酰亚胺 在 fac-tris(2-phenylpyridinato-N,C2')iridium(III) 作用下， 以 乙腈 为溶剂， 反应 28.0h， 生成 2-(2,6-dimethoxypyridin-3-yl)isoindoline-1,3-dione
  参考文献：
  名称：

  N-Acyloxyphthalimides as Nitrogen Radical Precursors in the Visible Light Photocatalyzed Room Temperature C–H Amination of Arenes and Heteroarenes

  摘要：

  This paper reports a room temperature visible light photocatalyzed method for the C-H amination of arenes and heteroarenes. A key enabling advance in this work is the design of N-acyloxyphthalimides as precursors to nitrogen-based radical intermediates for these transformations. A broad substrate scope is presented, including the selective meta-amination of pyridine derivatives. A radical aromatic substitution mechanism is proposed.

  DOI：

  10.1021/ja501906x

文献信息

• Thalidomide analogs
  申请人：Greig H. Nigel

  公开号：US20060211728A1

  公开（公告）日：2006-09-21

  Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.

  本文披露了调节肿瘤坏死因子α（TNF-α）活性和血管生成的沙利度胺类似物。特别是，本文披露了等构硫含类沙利度胺类似物。同时还披露了使用这些类似物治疗受试者的方法。
• THALIDOMIDE ANALOGS
  申请人：Greig Nigel H.

  公开号：US20110245210A1

  公开（公告）日：2011-10-06

  Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.

  本文披露了调节肿瘤坏死因子α（TNF-α）活性和血管生成的沙利度胺类似物。在特别披露的实施例中，沙利度胺类似物是同位素硫含量类似物。还披露了使用这些类似物治疗受试者的方法。
• Thalidomide Analogs
  申请人：Greig Nigel H.

  公开号：US20130035363A1

  公开（公告）日：2013-02-07

  Thalidomide analogs that modulate tumor necrosis factor alpha (TNFα) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.

  本发明揭示了调节肿瘤坏死因子α（TNFα）活性和血管生成的沙利度胺类似物。特别是，本发明揭示的沙利度胺类似物是等构硫含有的类似物。本发明还揭示了使用这些类似物治疗受试者的方法。
• Regioselective C(sp²)–H imidation of arenes by redox neutral visible-light photocatalysis
  作者：Manoj Kumar Ghosh、Kumari Swati Sharma、Ganesh Pandey

  DOI：10.1039/d2ob02040h

  日期：——

  neutral visible light-induced regioselective C(sp2)–H imidation of electron-rich arenes and heteroarenes using conceptually designed redox-active 1 as a source of the N-centered imidyl radical. Structurally diverse aromatic imides were obtained in moderate to good yields. This methodology has been successfully employed for the late stage imidation of complex molecules and has also been applied towards

  我们在此报道了一种氧化还原中性可见光诱导的富电子芳烃和杂芳烃的区域选择性 C(sp 2 )–H 亚胺化，使用概念设计的氧化还原活性1作为以 N 为中心的亚胺自由基的来源。以中等到良好的产率获得了结构多样的芳香族酰亚胺。该方法已成功用于复杂分子的后期酰亚胺化，也已应用于海洋天然产物 carpatamides A、B 和 D 的正式全合成。进一步表明，生成的酰亚胺可以很容易地转化为直接就地生成相应的苯胺。
• Photocatalytic C–H Activation and Amination of Arenes with Nonactivated <i>N</i>-Hydroxyphthalimides Involving Phosphine-Mediated N–O Bond Scission
  作者：Zhentao Pan、Bo Chen、Jingxi Fang、Tong Liu、Jiayao Fang、Yongmin Ma

  DOI：10.1021/acs.joc.2c01975

  日期：2022.11.4