ethyl bis(pentachlorophenyl)acetate | 141725-93-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl bis(pentachlorophenyl)acetate
• 英文别名: Ethyl 2,2-bis(2,3,4,5,6-pentachlorophenyl)acetate
• CAS: 141725-93-1
• 化学式: C₁₆H₆Cl₁₀O₂
• 分子量: 584.752
• InChiKey: HONFZGWESBHYMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl bis(pentachlorophenyl)acetate 在 硫酸 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 双(五氯苯基)甲烷
  参考文献：
  名称：

  Synthesis of the sterically hindered bis(pentachlorophenyl)acetic acid and derived stable free radicals

  摘要：

  Bis(pentachlorophenyl)acetic acid esters were synthesized from the alpha-hydroxydiaryl acetate esters 13 via the free radicals 15 formed on homolytic cleavage of the alpha-chloro compounds 14. The acid 8 underwent rapid decarboxylation in basic solution (e.g., Et3N in THF) but could be dehydrated to the corresponding ketene 17. Nucleophilic addition to the ketene provided a route to the corresponding amides (21 and 19) and nitrile 20, the enolates of which underwent ready oxidation to the corresponding stable free radicals 15, 22, and 23. Evidence for the structure and unusual stability of these free radicals is presented. Attempts to observe enols of acids or esters on the addition of water or alcohols to the sterically hindered ketene 17 were unsuccessful.

  DOI：

  10.1021/jo00042a021
• 作为产物：
  描述：

  ethyl decachlorobenzilate 在 三溴化磷 作用下， 以 二乙二醇二甲醚 为溶剂， 以83%的产率得到ethyl bis(pentachlorophenyl)acetate
  参考文献：
  名称：

  Synthesis of the sterically hindered bis(pentachlorophenyl)acetic acid and derived stable free radicals

  摘要：

  Bis(pentachlorophenyl)acetic acid esters were synthesized from the alpha-hydroxydiaryl acetate esters 13 via the free radicals 15 formed on homolytic cleavage of the alpha-chloro compounds 14. The acid 8 underwent rapid decarboxylation in basic solution (e.g., Et3N in THF) but could be dehydrated to the corresponding ketene 17. Nucleophilic addition to the ketene provided a route to the corresponding amides (21 and 19) and nitrile 20, the enolates of which underwent ready oxidation to the corresponding stable free radicals 15, 22, and 23. Evidence for the structure and unusual stability of these free radicals is presented. Attempts to observe enols of acids or esters on the addition of water or alcohols to the sterically hindered ketene 17 were unsuccessful.

  DOI：

  10.1021/jo00042a021

文献信息

• Synthesis of the sterically hindered bis(pentachlorophenyl)acetic acid and derived stable free radicals
  作者：Pat O'Neill、Anthony F. Hegarty

  DOI：10.1021/jo00042a021

  日期：1992.7

  Bis(pentachlorophenyl)acetic acid esters were synthesized from the alpha-hydroxydiaryl acetate esters 13 via the free radicals 15 formed on homolytic cleavage of the alpha-chloro compounds 14. The acid 8 underwent rapid decarboxylation in basic solution (e.g., Et3N in THF) but could be dehydrated to the corresponding ketene 17. Nucleophilic addition to the ketene provided a route to the corresponding amides (21 and 19) and nitrile 20, the enolates of which underwent ready oxidation to the corresponding stable free radicals 15, 22, and 23. Evidence for the structure and unusual stability of these free radicals is presented. Attempts to observe enols of acids or esters on the addition of water or alcohols to the sterically hindered ketene 17 were unsuccessful.