dimethylbenzenepropanol | 1000543-09-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethylbenzenepropanol
• 英文别名: 3-(2,3-dimethylphenyl)propan-1-ol；3-(2,3-dimethylphenyl)-1-propanol
• CAS: 1000543-09-8
• 化学式: C₁₁H₁₆O
• 分子量: 164.247
• InChiKey: WAKRZUVRHRIHCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  dimethylbenzenepropanol 生成 2,3-二甲基-苯丙醛
  参考文献：
  名称：

  WO2008/78291

  摘要：

  公开号：
• 作为产物：
  描述：

  3-(2,3-dimethylphenyl)-2-propyne-1-ol 在 palladium-carbon 氢气 作用下， 以 1,4-二氧六环 为溶剂， 反应 15.0h， 以to give the object product (1.93 g) as a brown oil的产率得到dimethylbenzenepropanol
  参考文献：
  名称：

  AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

  摘要：

  提供的是一种新型胺类化合物，其化学式表示为(I)，具有优异的外周血淋巴细胞减少作用、免疫抑制作用、排异抑制作用等，表现出例如心动过缓等副作用减少的优点，或其药学上可接受的酸加盐，或其水合物，或其溶剂化物。 其中，每个符号如规范中所定义。

  公开号：

  US20100179216A1

文献信息

• [EN] ALICYCLIC MUSK FRAGRANCE COMPOUNDS<br/>[FR] COMPOSÉS ALICYCLIQUES DE PARFUM MUSQUÉ
  申请人：SYMRISE AG

  公开号：WO2020125993A1

  公开（公告）日：2020-06-25

  The present invention primarily relates to the use of a compound according to the general formula (I) wherein i) m is 1, n is 1, o is 0 or 1, Y is Hydrogen, or ii) m is 2, n is 0, o is 1, Y is methyl, and wherein X is O or methylene, R and R1 are each methyl or form together with the carbon atom attached to a carbonyl group, and R2 is methyl, ethyl, propyl, butyl, butan-2-one-4-yl, tetrahydrofuran-2-yl, or tetrahydrofuran-3-yl, as perfuming ingredients. Moreover, the present invention relates to perfume compositions and perfumed products comprising the before mentioned perfuming ingredients. Still more particularly, the invention relates to a method for producing said perfumed products and a method of imparting and/or increasing musk odor characteristics to perfumed products. This invention also relates to a process for the preparation of said compounds according to the general formula (I).

  本发明主要涉及使用符合一般式(I)的化合物，其中i）m为1，n为1，o为0或1，Y为氢，或ii）m为2，n为0，o为1，Y为甲基，X为O或亚甲基，R和R1分别为甲基或与连接到羰基的碳原子形成一起的，R2为甲基、乙基、丙基、丁基、丁酮-2-基、四氢呋喃-2-基或四氢呋喃-3-基，作为香料成分。此外，本发明涉及包含上述香料成分的香水组合物和带有香水成分的香水产品。更具体地，本发明涉及生产所述香水产品的方法以及赋予和/或增加香水产品的麝香气味特征的方法。本发明还涉及根据一般式(I)制备所述化合物的方法。
• Synthesis and isolation of metal alkoxides
  申请人：Mine Safety Appliances Company

  公开号：US06444862B1

  公开（公告）日：2002-09-03

  A method for synthesizing highly soluble metal alkoxides includes the step of reacting a tertiary alcohol having the formula: wherein R1, R2, and R3 are, independently, the same or different, an alkyl group, an alkenyl, an alkynyl group or an aryl group, and at least one of R1, R2, and R3 is a group of at least 3 carbon atoms, with at least a stoichiometric amount of a metal reagent. The metal reagent is generally a group I metal, a group II metal, zinc, a metal alloy of a group I metal, a metal alloy of a group II metal, a metal alloy of zinc, a compound of a group I metal, a compound of a group II metal or a compound of zinc.

  一种合成高度可溶性金属烷氧基化合物的方法包括以下步骤：将具有以下公式的三级醇与至少一个配位量的金属试剂反应，其中R1、R2和R3独立地表示相同或不同的烷基、烯基、炔基或芳基，且R1、R2和R3中至少有一个是至少3个碳原子的基团。金属试剂通常是I族金属、II族金属、锌、I族金属的金属合金、II族金属的金属合金、锌的金属合金、I族金属的化合物、II族金属的化合物或锌的化合物。
• 5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES
  申请人：Aissaoui Hamed

  公开号：US20100093740A1

  公开（公告）日：2010-04-15

  The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I), wherein X represents CH 2 or O; R 1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R 2 represents (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 2-4 )alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR 5 R 6 or cyclopropyl; R 3 represents (C 1-4 )alkyl, (C 1-4 )alkoxy-methyl or halogen; R 4 represents (C 1-4 )alkyl; R 5 represents hydrogen or (C 1-4 )alkyl; and R 6 represents hydrogen or (C 1-4 )alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

  本发明涉及公式（I）的5,6,7,8-四氢咪唑[1,5-a]吡嗪衍生物，其中X代表CH2或O; R1代表苯基，该基团独立地单取代、双取代或三取代，其中取代基独立地选自由（C1-4）烷基，（C1-4）烷氧基，卤素，氰基，三氟甲氧基和三氟甲基的群组; R2代表（C1-4）烷基，（C1-4）烷氧基，（C2-4）烯基，卤素，氰基，羟甲基，三氟甲基，C（O）NR5R6或环丙基; R3代表（C1-4）烷基，（C1-4）烷氧甲基或卤素; R4代表（C1-4）烷基; R5代表氢或（C1-4）烷基; R6代表氢或（C1-4）烷基。本发明还涉及这种化合物的药学上可接受的盐;以及将这种化合物用作药物的用途;特别是作为促进睡眠激素受体拮抗剂。
• Amine compound and pharmaceutical use thereof
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：US08129361B2

  公开（公告）日：2012-03-06

  Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

  提供的是一种新型胺类化合物，其化学式如下（I），具有卓越的外周血淋巴细胞降低作用和免疫抑制作用，抗排异作用等方面表现出降低副作用的优点，例如心动过缓等，或其药学上可接受的酸盐，或其水合物，或其溶剂化物。 其中，每个符号如规范中所定义。
• Method for producing rotundone-containing mixtures
  申请人：SYMRISE AG

  公开号：US11028034B2

  公开（公告）日：2021-06-08

  The present invention relates to, according to a primary aspect, a method for manufacturing a mixture comprising rotundone. A further aspect of the present invention relates to mixtures containing rotundone as well as their use for generating, imparting or modifying, preferably enhancing, one or several taste and/or olfactory impressions. Moreover, the invention relates to a pharmaceutical preparation for nutrition, for oral care or for pleasure or a cosmetic pharmaceutical preparation or a pharmaceutical preparation intended for oral consumption or an intermediate good for manufacturing a pharmaceutical preparation for nutrition, for oral care or for pleasure or a cosmetic pharmaceutical preparation or a pharmaceutical preparation intended for oral consumption comprising a mixture according to the invention and furthermore to a method for manufacturing said preparation or intermediate good.

  本发明的一个主要方面涉及一种制造含罗通酮混合物的方法。本发明的另一个方面涉及含罗通酮的混合物及其用于产生、传递或改变（最好是增强）一种或多种味觉和/或嗅觉印象的用途。此外，本发明还涉及一种用于营养、口腔护理或愉悦的药物制剂，或一种用于美容的药物制剂，或一种用于口服的药物制剂，或一种用于制造营养、口腔护理或愉悦的药物制剂，或一种用于美容的药物制剂，或一种用于口服的药物制剂的中间产品，该中间产品包含一种根据本发明制成的混合物，还涉及一种制造所述制剂或中间产品的方法。