4-(3-aminophenyl)-2H-phthalazin-1-one | 391894-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(3-aminophenyl)-2H-phthalazin-1-one
• CAS: 391894-28-3
• 化学式: C₁₄H₁₁N₃O
• 分子量: 237.261
• InChiKey: NFARCWSYFRPOOP-UHFFFAOYSA-N

物化性质

• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-aminophenyl)-2H-phthalazin-1-one 在 盐酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 4-(3-aminophenyl)phthalazin-1(2H)-one hydrochloride
  参考文献：
  名称：

  NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE INHIBITORY ACTIVITY, AND USE THEREOF

  摘要：

  本发明涉及一种用于抑制ENPP1的化合物、一种用于抑制ENPP1的组合物，以及一种与抑制ENPP1的方法相关的新型酞嗪衍生物化合物，及其药学上可接受的盐、其水合物或其立体异构体。

  公开号：

  EP4148046A1

文献信息

• 2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient
  申请人：Ono Pharmaceutical Co., Ltd.

  公开号：US06677333B1

  公开（公告）日：2004-01-13

  Poly(ADP-ribose)polymerase inhibitors containing as the active ingredient 2H-phthalazin-1-one derivatives represented by general formula (I) (wherein each symbol is as defined in the description) or salts thereof. The compounds of the general formula (I) inhibit poly(ADP-ribose)polymerase and are useful as preventives and/or remedies for various ischemic diseases (brain, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory intestinal diseases, multiple encephalosclerosis, arthritis, etc.), nerve degeneration diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, etc.), diabetes, shock, head trauma, renal insufficiency, hyperalgesia, etc. These compounds are also useful as sensitizers for agents against retroviruses (HIV, etc.) and chemotherapy for cancer.

  聚(ADP-核糖)聚合酶抑制剂，其活性成分为一般式(I)所代表的2H-邻苯二酮衍生物，或其盐。一般式(I)的化合物抑制聚(ADP-核糖)聚合酶，可用作各种缺血性疾病（脑部、心脏、消化道、骨骼肌、视网膜等）、炎症性疾病（炎症性肠道疾病、多发性硬化症、关节炎等）、神经退行性疾病（锥体外症、阿尔茨海默病、肌营养不良等）、糖尿病、休克、头部外伤、肾功能不全、过敏症等的预防和/或治疗药物。这些化合物还可用作逆转录病毒（HIV等）和癌症化疗药物的增敏剂。
• 2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1148053A1

  公开（公告）日：2001-10-24

  Poly(ADP-ribose)polymerase inhibitors containing as the active ingredient 2H-phthalazin-1-one derivatives represented by general formula (I) (wherein each symbol is as defined in the description) or salts thereof. The compounds of the general formula (I) inhibit poly(ADP-ribose)polymerase and are useful as preventives and/or remedies for various ischemic diseases (brain, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory intestinal diseases, multiple encephalosclerosis, arthritis, etc.), nerve degeneration diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, etc.), diabetes, shock, head trauma, renal insufficiency, hyperalgesia, etc. These compounds are also useful as sensitizers for agents against retroviruses (HIV, etc.) and chemotherapy for cancer.

  聚(ADP-核糖)聚合酶抑制剂，其活性成分为通式(I)代表的 2H-酞嗪-1-酮衍生物（其中各符号如描述中所定义）或其盐。 通式（I）化合物可抑制聚（ADP-核糖）聚合酶，可用于预防和/或治疗各种缺血性疾病（脑、心脏、消化道、骨骼肌、视网膜等）、炎症性疾病（炎症性心肌梗塞、心肌梗死、心律失常、心肌梗死等）。这些化合物可用于预防和/或治疗各种缺血性疾病（脑部、心脏、消化道、骨骼肌、视网膜等）、炎症性疾病（肠道炎症性疾病、多发性脑硬化症、关节炎等）、神经变性疾病（锥体外系障碍、老年痴呆症、肌肉萎缩症等）、糖尿病、休克、头部外伤、肾功能不全、痛觉减退等。这些化合物还可用作抗逆转录病毒（HIV 等）药物和癌症化疗的增敏剂。
• US6677333B1
  申请人：——

  公开号：US6677333B1

  公开（公告）日：2004-01-13
• [EN] NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE INHIBITORY ACTIVITY, AND USE THEREOF<br/>[FR] NOUVEAU DÉRIVÉ DE PHTALAZINE AYANT UNE ACTIVITÉ D'INHIBITION DE L'ECTONUCLÉOTIDE PYROPHOSPHATASE/PHOSPHODIESTÉRASE, ET SON UTILISATION<br/>[KO] 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
  申请人：TXINNO BIOSCIENCE INC

  公开号：WO2021225407A1

  公开（公告）日：2021-11-11

  본 발명은 ENPP1의 억제를 위한 화합물, ENPP1의 억제를 위한 조성물 및 ENPP1의 억제를 위한 방법과 관련된 신규한 프탈라진 유도체 유도체 화합물, 이의 약학적으로 허용 가능한 염, 이의 수화물 또는 이의 입체 이성질체에 대한 발명이다.
• NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE INHIBITORY ACTIVITY, AND USE THEREOF
  申请人：Txinno Bioscience Inc.

  公开号：EP4148046A1

  公开（公告）日：2023-03-15

  The present invention relates to a compound for inhibiting ENPP1, a composition for inhibiting ENPP1, and a novel phthalazine derivative compound related to a method for inhibiting ENPP1, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof.

  本发明涉及一种用于抑制ENPP1的化合物、一种用于抑制ENPP1的组合物，以及一种与抑制ENPP1的方法相关的新型酞嗪衍生物化合物，及其药学上可接受的盐、其水合物或其立体异构体。