N-(phenazin-2-yl)benzamide | 304644-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(phenazin-2-yl)benzamide
• 英文别名: N-phenazin-2-ylbenzamide
• CAS: 304644-21-1
• 化学式: C₁₉H₁₃N₃O
• 分子量: 299.332
• InChiKey: XQYXDHAVRKKOHV-UHFFFAOYSA-N

物化性质

• 沸点：
  448.9±10.0 °C(predicted)
• 密度：
  1.342±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4-二硝基二苯胺 在 吡啶 、 5%-palladium/activated carbon 、 氢气 、 magnesium sulfate 作用下， 以 吡啶 、 二氯甲烷 、 乙酸乙酯 、 硝基苯 为溶剂， 反应 48.5h， 生成 N-(phenazin-2-yl)benzamide
  参考文献：
  名称：

  Synthesis and anticancer activity of some novel 2-phenazinamine derivatives

  摘要：

  In this study, we report the synthesis and spectral characterization of a novel series of 2-phenazinamine derivatives. In vitro evaluation for their anticancer activity toward cultured K562 (human chronic myelogenous leukemia), HepG2 (human hepatocellular carcinoma), MGC803 (human gastric carcinoma), HCT116 (human colorectal carcinoma), MCF7 (human breast adenocarcinoma) cell lines, as well as 293T (epithelial cells from human embryo kidney) non-cancer cell was carried out. The compounds 4, 7,16 and 19 showed good positive anticancer activity in vitro. In particular, compound 4, 2-chloro-N-(phenazin-2-yl)benzamide, possessed a potent anticancer effect comparable to cisplatin against both 1<562 and HepG2 cancer cells but was very low or had no effect against 293T non-cancer cell. Preliminary anticancer mechanism of 4 was investigated by cell apoptosis assays compared with cisplatin using flow cytometry. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.07.017

文献信息

• Methods For Reducing Superoxide Anions in Eukaryotic Organisms
  申请人：Burhans WIlliam C.

  公开号：US20130150336A1

  公开（公告）日：2013-06-13

  Provided are methods and compositions for reducing superoxide anions such that a prophylactic or therapeutic effect against conditions associated with excess oxidative stress achieved. The compositions and methods provide for reducing inflammation and for enhancing lifespan of eukaryotic organisms. A screen for identifying compounds that can be used in these methods is also provided.
• US9034857B2
  申请人：——

  公开号：US9034857B2

  公开（公告）日：2015-05-19