4-hydroxy-N-(3-methylbutyl)benzamide | 83191-69-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxy-N-(3-methylbutyl)benzamide
• CAS: 83191-69-9
• 化学式: C₁₂H₁₇NO₂
• mdl: MFCD11130943
• 分子量: 207.272
• InChiKey: BNGPRIYCBMCBDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异戊胺 、 4-acetoxybenzoyl chloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 4-hydroxy-N-(3-methylbutyl)benzamide
  参考文献：
  名称：

  On the Intractability of Estrogen-Related Receptor α as a Target for Activation by Small Molecules

  摘要：

  The estrogen-related receptor alpha (ERR alpha) is a potential target for activation in the treatment of metabolic disease. To date, no small-molecule agonists of ERR alpha have been identified despite several high-throughput screening campaigns. We describe the synthesis and profiling of a small array of compounds designed on the basis of a previously reported agonist-bound crystal structure of the closely related receptor ERR gamma. The results suggest that ERRa may be intractable as a direct target for pharmacologic activation.

  DOI：

  10.1021/jm7012387

文献信息

• Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists
  作者：Hua Lin、Christelle Doebelin、Rémi Patouret、Ruben D. Garcia-Ordonez、M.R. Chang、Venkatasubramanian Dharmarajan、Claudia Ruiz Bayona、Michael D. Cameron、Patrick R. Griffin、Theodore M. Kamenecka

  DOI：10.1016/j.bmcl.2018.03.019

  日期：2018.5

  Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule. Our structure activity relationship studies in this series revealed the phenol portion of the molecule to be required for activity. Attempts to replace the hydrazone with more suitable chemotypes led to a simple amide as a viable alternative. Differential hydrogen-deuterium

  在此，我们报告了一系列基于腙先导分子的简单酚酰胺 ERRγ 激动剂的设计和合成。我们在该系列中的构效关系研究揭示了分子的苯酚部分是活性所必需的。尝试用更合适的化学类型取代腙导致了一种简单的酰胺作为可行的替代品。微分氢-氘交换实验用于帮助理解与 ERRγ 结合的​​结构基础，并有助于开发更有效的配体。
• CHEMICALLY CLEAVABLE GROUP
  申请人：TAGWORKS PHARMACEUTICALS B.V.

  公开号：US20150344514A1

  公开（公告）日：2015-12-03

  Disclosed is the use of the reactive components of the inverse electron-demand Diels Alder reaction for chemical masking and unmasking in vitro. This can be applied in complex chemical reactions and, particularly in the synthesis of biomolecules, e.g. on solid supports. The reactive components are a dienophile, particularly a trans-cyclooctene, and a diene, particularly a tetrazine.

  本发明揭示了在体外使用反电子需求Diels-Alder反应的反应组分进行化学遮蔽和解除遮蔽的方法。这可以应用于复杂的化学反应中，特别是在生物分子的合成中，例如在固体支持体上。反应组分是二烯丙烯，特别是反式-环辛烯，和二烯，特别是四唑。
• Chemically cleavable group
  申请人：Tagworks Pharmaceuticals B.V.

  公开号：US10927139B2

  公开（公告）日：2021-02-23

  Disclosed is the use of the reactive components of the inverse electron-demand Diels Alder reaction for chemical masking and unmasking in vitro. This can be applied in complex chemical reactions and, particularly in the synthesis of biomolecules, e.g. on solid supports. The reactive components are a dienophile, particularly a trans-cyclooctene, and a diene, particularly a tetrazine.

  本发明公开了利用反电子需求 Diels Alder 反应的反应组分进行体外化学掩蔽和解除掩蔽的方法。这可用于复杂的化学反应，特别是生物大分子的合成，例如在固体支持物上的合成。反应组分是亲二烯（尤其是反式环辛烯）和二烯（尤其是四嗪）。
• On the Intractability of Estrogen-Related Receptor α as a Target for Activation by Small Molecules
  作者：Stephen M. Hyatt、Elizabeth L. Lockamy、Rebecca A. Stein、Donald P. McDonnell、Aaron B. Miller、Lisa A. Orband-Miller、Timothy M. Willson、William J. Zuercher

  DOI：10.1021/jm7012387

  日期：2007.12.27

  The estrogen-related receptor alpha (ERR alpha) is a potential target for activation in the treatment of metabolic disease. To date, no small-molecule agonists of ERR alpha have been identified despite several high-throughput screening campaigns. We describe the synthesis and profiling of a small array of compounds designed on the basis of a previously reported agonist-bound crystal structure of the closely related receptor ERR gamma. The results suggest that ERRa may be intractable as a direct target for pharmacologic activation.