rac.-2-(2-Chlor-4-nitrophenoxy)-propionsaeure | 21105-10-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: rac.-2-(2-Chlor-4-nitrophenoxy)-propionsaeure
• 英文别名: 2-(2-Chlor-4-nitrophenoxy)propionsaeure；2-(2-Chloro-4-nitrophenoxy)propanoic acid
• CAS: 21105-10-2
• 化学式: C₉H₈ClNO₅
• mdl: MFCD03422218
• 分子量: 245.619
• InChiKey: FPVGJIAXEJMVRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-氨基苯磺酰氟 、 rac.-2-(2-Chlor-4-nitrophenoxy)-propionsaeure 生成 4-[2-(2-Chloro-4-nitrophenoxy)propanoylamino]benzenesulfonyl fluoride
  参考文献：
  名称：

  不可逆酶抑制剂。CLXXIX。活性位点定向的不可逆酶抑制剂的二氢叶酸还原酶从1-（3-氯苯基）-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪与乙酰胺桥连接到末端磺酰氟。

  摘要：

  DOI：

  10.1021/jm00300a032
• 作为产物：
  描述：

  2-氯-4-硝基苯酚 在 sodium hydroxide 、 potassium carbonate 作用下， 生成 rac.-2-(2-Chlor-4-nitrophenoxy)-propionsaeure
  参考文献：
  名称：

  不可逆酶抑制剂。CLXXIX。活性位点定向的不可逆酶抑制剂的二氢叶酸还原酶从1-（3-氯苯基）-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪与乙酰胺桥连接到末端磺酰氟。

  摘要：

  DOI：

  10.1021/jm00300a032

文献信息

• Novel Herbicide Resistance Genes
  申请人：Wright Terry R.

  公开号：US20110203017A1

  公开（公告）日：2011-08-18

  The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.

  本发明提供了新的植物，不仅对2,4-D具有抗性，而且对吡啶氧乙酸类除草剂也具有抗性。迄今为止，没有预期或建议通过引入单个基因可以产生同时具有这两个优点的植物。本发明还包括将本发明的一个或多个酶“堆叠”在一起与一个或多个其他除草剂抗性基因一起产生的植物。本发明使得可以使用新的除草剂组合以新的方式。此外，本发明提供了预防和控制对一种或多种除草剂，如草甘膦具有抗性的杂草品系的新方法。根据本发明使用的首选酶和基因被称为AAD-12（芳氧烷基酸脱氧酶）。这一高度新颖的发现是显著的除草剂耐受作物性状和可选择标记机会的基础。
• NOVEL HERBICIDE RESISTANCE GENES
  申请人：Dow AgroSciences LLC

  公开号：US20130035233A1

  公开（公告）日：2013-02-07

  The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.

  本发明提供了一种新型植物，不仅对2,4-D具有抗性，而且对吡啶氧乙酸类除草剂也具有抗性。迄今为止，没有任何预期或建议表明引入单个基因可以产生同时具有这两种优势特性的植物。本发明还包括产生本发明中的一种或多种酶与一种或多种其他除草剂抗性基因“堆叠”在一起的植物。本发明使得新型除草剂的组合可以以新的方式使用。此外，本发明提供了一种防止和控制对一种或多种除草剂（如草甘膦）具有抗性的杂草品系的新方法。本发明中用于使用的首选酶和基因被称为AAD-12（芳氧烷基酸脱氧酶）。这一极其新颖的发现是显著的除草剂耐受作物特征和可选择标记机会的基础。
• USES AND DETECTION OF HERBICIDE RESISTANCE GENES FOR RESISTANCE TO ARYLOXYALKANOATE HERBICIDES
  申请人：Dow AgroSciences LLC

  公开号：US20130040815A1

  公开（公告）日：2013-02-14

  The subject invention provides novel plants that are not only resistant to 2,4-D, but also to a pyridyloxyacetate herbicide. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-13 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.

  本发明提供了新型植物，不仅对2,4-D具有抗性，还对吡啶氧乙酸类除草剂具有抗性。本发明还包括将本发明的一种或多种酶“叠加”在一起与一种或多种其他除草剂抗性基因一起产生的植物。本发明使得新型除草剂的组合可以以新的方式使用。此外，本发明提供了预防和控制对一种或多种除草剂如草甘膦具有抗性的杂草株的新方法。本发明中用于使用的首选酶和基因被称为AAD-13（芳氧基烷酸双加氧酶）。这一高度新颖的发现是显著的除草剂耐受农作物特征和可选择标记机会的基础。
• ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS
  申请人：The Hong Kong Polytechnic University

  公开号：US20150011513A1

  公开（公告）日：2015-01-08

  A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters. The EC50 values for reversing paclitaxel resistance (141-340 nM) of LCC6MDR cells, DOX (78-590 nM) and vincristine (82-550 nM) resistance of 2008/MRP1 cells and topotecan resistance (0.9-135 nM) of HEK293/R2 and MCF7-MX100 cells were at nanomolar range. Importantly, a number of compounds displayed EC50 at or below 10 nM in BCRP-overexpressed cell lines, indicating that these bivalent triazoles more selectively inhibit BCRP transporter than the P-gp and MRP1 transporters. Most of the dimers are notably safe MDR chemosensitizers as indicated by their high therapeutic index values.

  通过一系列含有三唑桥联类黄酮二聚物的合成，使用环加成反应，利用一系列含有黄酮基团的叠氮化物（Az1-15）和炔烃（Ac1-17）构建了一个高效的化合物库。这些三唑桥联的类黄酮二聚体及其前体炔基和叠氮基类黄酮被筛选，以评估它们对过表达P-gp的细胞系（LCC6MDR）、MRP1过表达的细胞系（2008/MRP1）和BCRP过表达的细胞系（HEK293/R2和MCF7-MX100）调节多药耐药性（MDR）的能力。总体而言，它们展现了极具前景的P-gp、MRP1和BCRP介导的药物耐药性的MDR逆转活性。此外，它们显示出对各种转运体的不同程度的选择性。总体而言，它们可以分为单选择性、双选择性和多选择性的P-gp、MRP1和BCRP转运体调节剂。对于LCC6MDR细胞的紫杉醇耐药性（141-340 nM）、2008/MRP1细胞的DOX（78-590 nM）和长春新碱（82-550 nM）耐药性以及HEK293/R2和MCF7-MX100细胞的拓扑替康耐药性（0.9-135 nM），它们的EC50值处于纳摩尔范围。重要的是，许多化合物在BCRP过表达的细胞系中显示出EC50值在或低于10 nM，表明这些双价三唑更有选择性地抑制BCRP转运体而不是P-gp和MRP1转运体。大多数二聚体的治疗指数值非常高，表明它们是非常安全的MDR化疗敏感剂。
• Novel herbicide resistance genes
  申请人：Dow AgroSciences LLC

  公开号：EP2484202A1

  公开（公告）日：2012-08-08

  The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention "stacked" together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.

  本发明提供的新型植物不仅能抗 2,4-D，还能抗吡啶氧乙酸酯除草剂。在此之前，人们并不期望或认为通过引入单个基因就能培育出具有上述两种优势特性的植物。本发明还包括产生一种或多种本发明酶与一种或多种其他抗除草剂基因 "叠加 "在一起的植物。本发明可使除草剂以新的方式组合使用。此外，本发明还提供了预防和控制对一种或多种除草剂（如草甘膦）具有抗性的杂草品系的新方法。根据本发明，优选使用的酶和基因被称为 AAD-12（芳氧基烷酸二加氧酶）。这一高度新颖的发现是重要的耐除草剂作物性状和可选择标记机会的基础。