R-(-)-O-Methylmandelic acid chloride | 1226601-65-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: R-(-)-O-Methylmandelic acid chloride
• 英文别名: R-(-)-O-methylmandeloyl chloride；(2R)-2-hydroxy-2-(2-methylphenyl)acetyl chloride
• CAS: 1226601-65-5
• 化学式: C₉H₉ClO₂
• 分子量: 184.622
• InChiKey: DLGUOTFONDNAHO-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  petroleum 、 hydrochloric acid-saturated ether 、 R-(-)-O-Methylmandelic acid chloride 、 1,2,3,4-四氢-N-环丙基-5-甲氧基-1-甲基-2-萘胺 、 potassium tert-butylate 、 R-(-)-O-methylmandelic acid 生成 (-)-cis-5-methoxy-1-methyl-2-(N-cyclopropylmethylamino)tetralin hydrochloride
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• TRANS-FUSED CHROMENOISOQUINOLINES SYNTHESIS AND METHODS FOR USE
  申请人：Nichols David

  公开号：US20090030025A1

  公开（公告）日：2009-01-29

  Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein.

  本文描述了可选地替代的咔唑啉和类似物及其衍生物。此外，本文还描述了这些化合物的合成方法。此外，本文还描述了这些化合物作为多巴胺受体结合化合物的用途。
• Therapeutically useful 1-alkyl-2-aminotetralin derivatives
  申请人：Astra Läkemedel Aktiebolag

  公开号：EP0064964A1

  公开（公告）日：1982-11-17

  Compounds of the formula wherein R3 and the NR1R2 group are in a cis-position to each other and wherein Y is OH, R4COO, (R5)2NCOO or R60 either in position 5 or position 7, whereby R4 is an alkyl group having 1-5 carbon atoms or a possibly substituted phenyl group, R5 is an alkyl group having 1-5 carbon atoms and R6 is an allyl or benzyl group, R1 is hydrogen or an alkyl group having 1-3 carbon atoms, R2 is an alkyl group having 1-6 carbon atoms, a phenylalkyl- or m-hydroxyphenylalkyl group with 2-4 carbon atoms in the alkyl part, or an alkenyl group with 3-6 carbon atoms other than 1-alkenyl, and R3 is an alkyl group having 1-3 carbon atoms, processes and intermediates for their preparation, pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.

  式中的化合物 其中 R3 和 NR1R2 互为顺式位置，Y 为 OH、R4COO、(R5)2NCOO 或位于位置 5 或位置 7 的 R60，其中 R4 为具有 1-5 个碳原子的烷基或可能取代的苯基，R5 为具有 1-5 个碳原子的烷基，R6 为烯丙基或苄基，R1 为氢或具有 1-3 个碳原子的烷基、R2 是具有 1-6 个碳原子的烷基、烷基部分含有 2-4 个碳原子的苯基烷基或间羟苯基烷基，或除 1-烯基以外的具有 3-6 个碳原子的烯基，R3 是具有 1-3 个碳原子的烷基，以及制备这些化合物的工艺和中间体、药物制剂和使用这些化合物的治疗方法。这些化合物可用于治疗目的，特别是治疗中枢神经系统疾病。
• Octahydrobenzo(f)quinoline derivatives
  申请人：Carlsson, Per Arvid Emil

  公开号：EP0127597A1

  公开（公告）日：1984-12-05

  Compounds of the formula wherein C' and N4 are in trans configuration to each other, Y is OH, R'COO, R2R3NCOO- or R4O whereby R' is an aliphatic hydrocarbon residue having 1-17 carbon atoms, a phenyl, 2,6-dimethylphenyl or 3- or 4-hydroxyphenyl group or a 3- or 4-alkanoyloxyphenyl group with the formula wherein R5 is an alkyl group having 1-6 carbon atoms, or R' is a group wherein R6 is hydrogen, an alkyl group having 1 to 5 carbon atoms or a phenyl group, R7 is hydrogen, an alkyl group having 1 to 5 carbon atoms or an acyl group and R8 is hydrogen or an alkyl group having 1 to 5 carbon atoms, R2 is hydrogen, an alkyl group having 1-5 carbon atoms, a phenethyl, benzyl or phenyl group which may be mono- or disubstituted in the aromatic part with a methyl, methoxy, hydroxy, nitro or cyano group or a halogen, R' is H, an alkyl group having 1 to 5 carbon atoms or a phenyl group or R2 and R3 together with the nitrogen atom form a 5, 6 or membered ring that may contain 1 to 3 double bonds and/or 1 or further hetero-atoms selected from N, 0 and S, and R4 is an allyl or benzyl group and R is hydrogen or the group wherein n is 3 or 4 and R9 is hydrogen, an alkanoyl group having 2-6 carbon atoms or benzoyl, as bases and pharmaceutically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for treatment of disorders in the central nervous system.

  式中的化合物 其中C'和N4互为反式构型，Y为OH、R'COO、R2R3NCOO-或R4O，其中R'为具有1-17个碳原子的脂肪族烃残基、苯基、2,6-二甲基苯基或3-或4-羟基苯基或3-或4-烷酰氧基苯基，其式为 其中 R5 是具有 1-6 个碳原子的烷基，或 R' 是一个基团 其中 R6 是氢、具有 1 至 5 个碳原子的烷基或苯基，R7 是氢、具有 1 至 5 个碳原子的烷基或酰基，R8 是氢或具有 1 至 5 个碳原子的烷基，R2 是氢、具有 1 至 5 个碳原子的烷基、苯乙基、苄基或苯基，这些基团可在芳香族部分与甲基、甲氧基、羟基、硝基、苄基、苄基或苄基进行单取代或二取代、R'是氢、具有 1 至 5 个碳原子的烷基或苯基，或 R2 和 R3 与氮原子一起形成一个 5、6 或成员环，该环可能含有 1 至 3 个双键和/或 1 个或多个选自 N、0 和 S 的杂原子，R4 是烯丙基或苄基，R 是氢或以下基团 其中 n 为 3 或 4，R9 为氢、具有 2-6 个碳原子的烷酰基或苯甲酰基，作为碱及其药学上可接受的酸加成盐、其制备工艺和药物制剂以及使用此类化合物的治疗方法。这些化合物可用于治疗中枢神经系统疾病。
• NEW OCTAHYDROBENZO (f) QUINOLINE DERIVATIVES
  申请人：Carlsson, Per Arvid Emil

  公开号：EP0172821B1

  公开（公告）日：1989-09-13
• Therapeutically useful tetralin derivatives
  申请人：THE UPJOHN COMPANY

  公开号：EP0334538B1

  公开（公告）日：1992-12-02