3-(2'-hydroxy-3'-phenoxypropyl)imidazolidine-2,4-dione | 1276127-19-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(2'-hydroxy-3'-phenoxypropyl)imidazolidine-2,4-dione
• 英文别名: 3-(2-hydroxy-3-phenoxypropyl)imidazolidine-2,4-dione
• CAS: 1276127-19-5
• 化学式: C₁₂H₁₄N₂O₄
• 分子量: 250.254
• InChiKey: XTYYFAVDICOMAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  海因 、 苯基缩水甘油醚 在 吡啶 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以0.51 g的产率得到3-(2'-hydroxy-3'-phenoxypropyl)imidazolidine-2,4-dione
  参考文献：
  名称：

  Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

  摘要：

  The synthesis and inhibitory potencies of a novel series of beta-amino alcohols, based on the hit-compound 3-[3`-(4 ''-cyclopent-2```-en-1```-ylphenoxy)-2`-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.099

文献信息

• Silica Sulfuric Acid (SSA) as a Highly Efficient Heterogeneous Catalyst for Persilylation of Purine and Pyrimidine Nucleobases and Other <i>N</i>-Heterocycles Using Hmds
  作者：Mohammad Navid Soltani Rad、Ali Khalafi-Nezhad、Masoumeh Divar、Somayeh Behrouz

  DOI：10.1080/10426500903383952

  日期：2010.8.25

  Purine and pyrimidine nucleobases and other N-heterocycles have been silylated with HMDS in excellent yields in the presence of a catalytic amount of silica sulfuric acid (SSA) as a heterogeneous catalyst. SSA utilizes a shorter reaction time and higher yields of silylated nucleobases. SSA is reusable for several times without a decrease in reactivity or yield of silylated adducts.
• Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase
  作者：Elizabeth Fullam、Areej Abuhammad、David L. Wilson、Matthew C. Anderton、Steve G. Davies、Angela J. Russell、Edith Sim

  DOI：10.1016/j.bmcl.2010.12.099

  日期：2011.2

  The synthesis and inhibitory potencies of a novel series of beta-amino alcohols, based on the hit-compound 3-[3`-(4 ''-cyclopent-2```-en-1```-ylphenoxy)-2`-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined. (c) 2010 Elsevier Ltd. All rights reserved.