[2-(ethoxy-hydroxy-phosphoryloxy)-ethyl]-trimethyl-ammonium betaine | 22080-28-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [2-(ethoxy-hydroxy-phosphoryloxy)-ethyl]-trimethyl-ammonium betaine
• 英文别名: [2-(Aethoxy-hydroxy-phosphoryloxy)-aethyl]-trimethyl-ammonium-betain；Phosphorsaeure-aethylester-cholinester-betain；ethyl 2-(trimethylammonio)ethyl phosphate；Ammonium,(2-hydroxyethyl),trimethyl, hydroxide ethyl hydrogen phosphate innersalt；Aethyl-<2-trimethyl-ammonio-aethyl>-phosphat；2-[(Ethoxyhydroxyphosphinyl)oxy]-N,N,N-trimethylethanaminium Inner Salt；ethyl 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 22080-28-0
• 化学式: C₇H₁₈NO₄P
• 分子量: 211.198
• InChiKey: JGENYNHRIOHZOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  十二/十四烷基二甲基氧化胺 、 2-乙氧基-1,3,2-二氧杂磷杂环戊烷 在 三甲胺 作用下， 以 丙酮 、 乙腈 为溶剂， 生成 [2-(ethoxy-hydroxy-phosphoryloxy)-ethyl]-trimethyl-ammonium betaine
  参考文献：
  名称：

  Brault,J.-F.; Chabrier,P., Bulletin de la Societe Chimique de France, 1974, p. 677 - 680

  摘要：

  DOI：

文献信息

• COSMETICS OR DERMATOLOGICAL PREPARATIONS CONTAINING POLYMERS HAVING PHOSPHORYLCHOLINE SIDE CHAIN
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1306090A1

  公开（公告）日：2003-05-02

  Provided is a cosmetic or a dermatological composition comprising as an active ingredient, a specific acryl base copolymer having phosphorylcholine as a side chain or a pendant group. Such active ingredient can inhibit or repair skin damages by strengthening the expression of a β-glucocerebrosidase gene.

  本发明提供了一种化妆品或皮肤科组合物，其活性成分是一种特定的丙烯酸基共聚物，该共聚物具有磷酰胆碱作为侧链或悬垂基团。这种活性成分可以通过加强 β-葡糖脑苷脂基因的表达来抑制或修复皮肤损伤。
• IMMUNOSTIMULATORY LIPOPLEX, PHARMACEUTICAL COMPOSITION INCLUDING IMMUNOSTIMULATORY LIPOPLEX, AND USES THEREOF
  申请人：Industrial Technology Research Institute

  公开号：EP4019006A1

  公开（公告）日：2022-06-29

  An immunostimulatory lipoplex is provided. The immunostimulatory lipoplex includes a liposome and at least one immunostimulatory nucleic acid drug, and the immunostimulatory nucleic acid drug is complexed with the liposome. The liposome includes 40 to 85 mol% of cationic lipid, 10 to 50 mol% of cholesterol, and 0.001 to 20 mol% of modified polyethylene glycol lipid. A pharmaceutical composition including the immunostimulatory lipoplex is also provided.

  提供了一种免疫刺激脂质体。免疫刺激脂质体包括脂质体和至少一种免疫刺激核酸药物，免疫刺激核酸药物与脂质体复合。脂质体包括 40 至 85 摩尔%的阳离子脂质、10 至 50 摩尔%的胆固醇和 0.001 至 20 摩尔%的改性聚乙二醇脂质。还提供了一种包括免疫刺激脂质体的药物组合物。
• Stimulation of an immune response by enantiomers of cationic lipids
  申请人：PDS Biotechnology Corporation

  公开号：US10702541B2

  公开（公告）日：2020-07-07

  A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in R1 is a quaternary ammonium group, Y1 is a spacer chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, R2 and R3 are independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combinations thereof.

  一种活化体内外免疫细胞或诱导受试者免疫反应的组合物和方法，包括一种包含至少一种手性阳离子脂质的组合物。手性阳离子脂质在一个实施方案中包括具有由式（I）表示的结构的非甾体阳离子脂质；其中，R1是季铵基团，Y1是选自烃链、酯、酮和肽的间隔物，C*是手性碳，R2和R3独立地选自饱和脂肪酸、不饱和脂肪酸、酯链烃、磷-二酯及其组合。
• Intracellular substance transport system and use thereof
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US11007276B2

  公开（公告）日：2021-05-18

  The present invention pertains to a complex including nanoparticles and, carried on the surface of the nanoparticles, a lysosomal enzyme inhibitor or kinase inhibitor shown by general formula (A) and a phospholipid mimetic substance shown by general formula (B). In general formula (A), n1 is an integer of 2-30, n2 is an integer of 2-30, the -S- terminal is a nanoparticle-carrying site, and R10 is a suicide substrate site or a kinase inhibition site. In general formula (B), n3 is an integer in the range of 2-30, and the -S- terminal is a nanoparticle-carrying site. The present invention provides a versatile system capable of efficiently delivering a drug to endolysosomes and allowing the drug to function at a low concentration on lysosomal enzymes, and an anticancer agent in which this system is used.

  本发明涉及一种复合物，包括纳米颗粒和纳米颗粒表面携带的通式（A）所示的溶酶体酶抑制剂或激酶抑制剂以及通式（B）所示的磷脂模拟物质。 通式（A）中，n1 为 2-30 的整数，n2 为 2-30 的整数，-S- 端为纳米粒子携带位点，R10 为自杀底物位点或激酶抑制位点。通式（B）中，n3 是 2-30 范围内的整数，-S- 端是纳米粒子携带位点。本发明提供了一种多功能系统，能够有效地将药物输送到内溶酶体，并使药物以低浓度作用于溶酶体酶，还提供了一种使用该系统的抗癌剂。
• Cosmetics or dermatological preparations containing polymers having phosphorylcholine side chain
  申请人：——

  公开号：US20040013628A1

  公开（公告）日：2004-01-22

  Provided is a cosmetic or a dermatological composition comprising as an active ingredient, a specific acryl base copolymer having phosphorylcholine as a side chain or a pendant group. Such active ingredient can inhibit or repair skin damages by strengthening the expression of a &bgr;-glucocerebrosidase gene.

  本发明提供了一种化妆品或皮肤科组合物，其活性成分是一种特定的丙烯酰基共聚物，该共聚物以磷酸胆碱作为侧链或悬垂基团。这种活性成分可以通过加强&bgr;-葡糖脑苷脂基因的表达来抑制或修复皮肤损伤。