4-Mercaptopyrrolo<2,3-d>pyrimidin | 1421-27-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 4-Mercaptopyrrolo<2,3-d>pyrimidin
• 英文别名: Pyrrolo[2,3-d]pyrimidine-4-thione；1,7-dihydropyrrolo[2,3-d]pyrimidine-4-thione
• CAS: 1421-27-8
• 化学式: C₆H₅N₃S
• mdl: MFCD01686812
• 分子量: 151.192
• InChiKey: HTDPDLVWFWOIBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.3
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  4-Mercaptopyrrolo<2,3-d>pyrimidin 在 镍 sodium hydroxide 、 四丁基硫酸氢铵 作用下， 以 ammonium hydroxide 、 乙二醇二甲醚 为溶剂， 反应 7.5h， 生成 7,7'-Methylendi(7H-pyrrolo<2,3-d>pyrimidin)
  参考文献：
  名称：

  Seela, Frank; Steker, Herbert, Liebigs Annalen der Chemie, 1983, # 9, p. 1576 - 1587

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯吡咯并嘧啶 在 硫脲 作用下， 以 乙醇 为溶剂， 以92.4%的产率得到4-Mercaptopyrrolo<2,3-d>pyrimidin
  参考文献：
  名称：

  ＪＡＫ-3 저해제로 유용한 ７Ｈ-피롤로[2,3-ｄ]피리미딘-4-싸이올 유도체

  摘要：

  This is the translation of the text you provided: This invention relates to a method for preparing a novel 7H-pyrrolo[2,3-d]pyrimidine-4-thiol derivative or a pharmaceutically acceptable salt thereof and pharmaceutical compositions containing it as an active ingredient. Compositions containing the novel 7H-pyrrolo[2,3-d]pyrimidine-4-thiol derivative according to the present invention can be useful for the prevention or treatment of diseases induced by the overactivity of Janus kinase (JAK).

  公开号：

  KR101683061B1

文献信息

• [EN] PROCESSES FOR MAKING PRMT5 INHIBITORS<br/>[FR] PROCÉDÉS DE FABRICATION D'INHIBITEURS DE PRMT5
  申请人：PRELUDE THERAPEUTICS INC

  公开号：WO2022125735A1

  公开（公告）日：2022-06-16

  The disclosure provides processes for preparing the compound of formula (VIII) and pharmaceutically acceptable salts thereof. Intermediates useful in preparing the compound of formula (VIII) are also provided.

  本公开提供了制备化合物式（VIII）及其药学上可接受的盐的过程。还提供了制备化合物式（VIII）的中间体。
• 7-Beta-D-arabinofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-4-amine 5'-phosphate compounds useful as antiviral agents, pharmaceutical compositions containing the compounds, and processes for producing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0057548A2

  公开（公告）日：1982-08-11

  7-β-D-arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine, its hydroxy, amino and sulfhydryl derivatives, corresponding esters and non-toxic pharmaceutically acceptable salts are disclosed. Such compounds may be produced by arabinofura- nosylation of the requisite heterocyclic compound, with 2,3,5-tri-O-benzyl-a-D-arabinofuranosyl halide and further reaction to obtain the desired compound. These water-soluble compounds are resistant to adenosine deaminase and exhibit antiviral activity.

  本发明公开了 7-β-D-阿拉伯呋喃糖基-7H-吡咯并[2,3-d]嘧啶、其羟基、氨基和巯基衍生物、相应的酯和无毒的药学上可接受的盐。这些化合物可以通过将所需的杂环化合物与 2,3,5-三-O-苄基-a-D-阿拉伯呋喃糖基卤化物进行阿拉伯呋喃糖基化，并进一步反应得到所需的化合物。这些水溶性化合物对腺苷脱氨酶有抗性，并具有抗病毒活性。
• Seela, Frank; Steker, Herbert, Liebigs Annalen der Chemie, 1984, # 10, p. 1719 - 1730
  作者：Seela, Frank、Steker, Herbert

  DOI：——

  日期：——
• Chemical Fragment Screening and Assembly Utilizing Common Chemistry for NMR Probe Introduction and Fragment Linkage
  申请人：Sem Daniel S.

  公开号：US20100305326A1

  公开（公告）日：2010-12-02

  Disclosed herein are methods related to drug development. The methods typically include steps whereby two chemical fragments are identified as binding to a target protein and subsequently the two chemical fragments are joined to create a new chemical entity that binds to the target protein.
• SCN9A ANTISENSE OLIGONUCLEOTIDES
  申请人：OliPass Corporation

  公开号：US20190218255A1

  公开（公告）日：2019-07-18

  The current invention provides peptide nucleic acid derivatives targeting a part of the human SCN9A pre-mRNA. The peptide nucleic acid derivatives potently induce splice variants of the SCN9A mRNA in cells, and are useful to safely treat pains or conditions involving Na v 1.7 activity.