tert-Butyl-dimethyl-(1-methyl-2-phenyl-ethoxy)-silane | 112471-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-Butyl-dimethyl-(1-methyl-2-phenyl-ethoxy)-silane
• 英文别名: tert-Butyl(dimethyl)[(1-phenylpropan-2-yl)oxy]silane；tert-butyl-dimethyl-(1-phenylpropan-2-yloxy)silane
• CAS: 112471-50-8
• 化学式: C₁₅H₂₆OSi
• 分子量: 250.456
• InChiKey: FVZRCCFPCDUQOC-UHFFFAOYSA-N

物化性质

• 沸点：
  284.2±19.0 °C(Predicted)
• 密度：
  0.893±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.64
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tert-Butyl-dimethyl-(1-methyl-2-phenyl-ethoxy)-silane 在 三氯溴甲烷 作用下， 以71 %的产率得到1-苯基-2-丙醇
  参考文献：
  名称：

  一种脱除醇上硅类保护基的方法

  摘要：

  本发明公开了一种脱除醇上多种硅类保护基(‑SiR’3)的方法。该方法包括以下步骤：将原料(RO‑SiR’3)与催化剂加入到含有溶剂的反应瓶中，在7W UV灯或目光照射下反应4～8h，将反应产物提纯后得到相应的脱除硅类的醇(ROH)；其中，所述原料为醇的不同硅醚(RO‑SiR’3)；所述催化剂为三氯溴甲烷(BrCCl3)，所述溶剂为甲醇、乙醇或其混合溶剂。本发明方法操作简单、条件温和、产率高(70～98％)、适用性广、原料廉价易得、节能环保，为脱除醇上硅类保护基提供了一条更好的途径。

  公开号：

  CN116606185A

文献信息

• Application of SO3H Silica Gel to Deprotection of Silyl Ethers
  作者：Hiroshi Nagase、Hideaki Fujii、Takaaki Yamada、Miki Kuwada、Atom Hamasaki、Kazunori Nobuhara、Sumio Ozeki、Kohei Hayashida

  DOI：10.3987/com-12-12577

  日期：——

  A newly developed SO3H silica gel cleaved the O-Si bonds in various aryl and alkyl silyl ethers to give the corresponding phenols and alcohols in good to excellent yield. The crude filtrates contained no silyl residues. The solid phase Si-29 NMR analyses of the SO3H silica gel strongly suggested that the silyl residues were captured by silanol groups on the surface of the silica gel. The SO3H silica gel could be recycled at least ten times without any loss of activity. The disappearance of silyl residues in the crude filtrate was observed in even the 10th repetition. Our method provides an easily handled desilylation method that requires no further purification. Our method was also applicable to a selective desilylation reaction of a derivative 5 with different siloxy groups or desilylation of an alkaloid derivative 7.
• A one-step and chemoselective conversion of silyl-protected alcohols into the corresponding acetates
  作者：Takeshi Oriyama、Mihoko Oda、Junko Gono、Gen Koga

  DOI：10.1016/s0040-4039(00)73040-1

  日期：1994.3

  A reagent system of acetyl bromide combined with a catalytic amount of tin(II) bromide cleaves readily trialkylsilyl ethers to give the corresponding acetates in high yields under very mild conditions.
• Oriyama Takeshi, Oda Mihoko, Gono Junko, Koga Gen, Tetrahedron Lett, 35 (1994) N 13, S 2027-2030
  作者：Oriyama Takeshi, Oda Mihoko, Gono Junko, Koga Gen

  DOI：——

  日期：——