2-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-6-[2-[2-[2-[[2-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1,3-dioxobenzo[de]isoquinolin-6-yl]amino]ethoxy]ethoxy]ethylamino]benzo[de]isoquinoline-1,3-dione | 228406-67-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-6-[2-[2-[2-[[2-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1,3-dioxobenzo[de]isoquinolin-6-yl]amino]ethoxy]ethoxy]ethylamino]benzo[de]isoquinoline-1,3-dione
• 英文别名: 2-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-6-[2-[2-[2-[[2-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1,3-dioxobenzo[de]isoquinolin-6-yl]amino]ethoxy]ethoxy]ethylamino]benzo[de]isoquinoline-1,3-dione
• CAS: 228406-67-5
• 化学式: C₄₂H₅₂N₆O₁₀
• 分子量: 800.909
• InChiKey: FATGBSYFASWUAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  58
• 可旋转键数：
  27
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  206
• 氢给体数：
  4
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  1,8-二氨基-3,6-二氧杂辛烷 、 4-溴-1,8-萘二甲酸酐 生成 2-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-6-[2-[2-[2-[[2-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1,3-dioxobenzo[de]isoquinolin-6-yl]amino]ethoxy]ethoxy]ethylamino]benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING
  [FR] COMPOSITIONS ET MÉTHODES D'UTILISATION DES COMPOSITIONS POUR RAMOLLIR DES PLAQUES CALCIFIÉES

  摘要：

  公开号：

  WO2014022807A3

文献信息

• Methods of acute restoration of vascular compliance
  申请人：Alumend, LLC

  公开号：US10959995B2

  公开（公告）日：2021-03-30

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

  本文公开了一种用于血管的组合物中的化合物，其中的化合物能软化和/或破坏钙化斑块的结晶基质，并能迅速恢复血管治疗部位的血管顺应性，同时在血管成形术期间保持管腔增大。还公开了包括应用所公开组合物的治疗方法。还公开了斑块软化化合物。
• METHODS OF ACUTE RESTORATION OF VASCULAR COMPLIANCE
  申请人：ALUMEND, LLC

  公开号：US20160030413A1

  公开（公告）日：2016-02-04

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.
• COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING
  申请人：ALUMEND, LLC

  公开号：US20160046584A1

  公开（公告）日：2016-02-18

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.
• [EN] ENDOVASCULAR MULTI-BALLOON CATHETHERS WITH OPTICAL DIFFUSER FOR TREATMENT OF VASCULAR STENOSES<br/>[FR] CATHÉTERS À BALLONS MULTIPLES ENDOVASCULAIRES À DIFFUSEUR OPTIQUE POUR LE TRAITEMENT DE STÉNOSES VASCULAIRES
  申请人：ALUMEND LLC

  公开号：WO2014022867A1

  公开（公告）日：2014-02-06

  An interventional vascular therapeutic device (100) including a catheter shaft (110) having a pair of occlusion balloons (132, 134), a dilatation balloon (136) disposed on the catheter shaft between the occlusion balloons, a first inflation lumen (112) and a second inflation lumen (113) cofigured to supply inflation fluid to a proximally disposed one and a distal on of the occlusion balloons, a third inflation lumen (115) configured to supply inflation fluid to the dilatation balloon, a primary lumen (111) extending the entire length of the catheter configured to slidably receive a guidewire, and an infusion lumen (114) extending from a proximal end of the catheter shaft toward the distal end of the catheter shaft and terminating at an infusion exit port (140) located between the occlusion balloons. The device including an optical fiber (480) configured to be inserted into the primary lumen in exchange for the guidewire.
• [EN] COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING<br/>[FR] COMPOSITIONS ET MÉTHODES D'UTILISATION DES COMPOSITIONS POUR RAMOLLIR DES PLAQUES CALCIFIÉES
  申请人：ALUMEND LLC

  公开号：WO2014022807A3

  公开（公告）日：2014-05-30