2-amino-1,4-dihydro-6-methyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester | 50550-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-1,4-dihydro-6-methyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester
• 英文别名: 2-amino-4-phenyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester；2-amino-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester；(+/-)-2-amino-1,4-dihydro-6-methyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester；(+/-)-2-amino-1,4-dihydro-6-methyl-4-phenylpyridine-3,5-dicarboxylic acid diethyl ester；2-amino-1,4-dihydro-6-methyl-4-phenylpyridine-3,5-dicarboxylic acid diethyl ester；2-amino-6-methyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester；diethyl 2-amino-6-methyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 50550-91-9
• 化学式: C₁₈H₂₂N₂O₄
• 分子量: 330.384
• InChiKey: UZYJNISTYPQLBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  90.6
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-amino-1,4-dihydro-6-methyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester 在 六氯乙烷 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 6.67h， 生成 2-Ethoxy-3,4,5,8-tetrahydro-7-methyl-4-oxo-3,5-diphenylpyrido<2,3-d>pyrimidin-6-carbonsaeure-ethylester
  参考文献：
  名称：

  Wamhoff, Heinrich; Paasch, Joachim, Liebigs Annalen der Chemie, 1990, # 10, p. 995 - 999

  摘要：

  DOI：
• 作为产物：
  描述：

  (E)-ethyl 2-benzylidene-3-oxobutanoate 、 3-氨基-3-亚氨基丙酸乙酯 生成 2-amino-1,4-dihydro-6-methyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  MEYER, H.;WEHINGER, E.;BOSSERT, F.;STOEPEL, K.;VATER, W., ARZNEIMITTEL-FORSCH., 1981, 31, N 8, 1173-1177

  摘要：

  DOI：

文献信息

• 4-alkoxy-pyrido[2,3-d]pyrimidine derivatives
  申请人：Godecke Aktiengesellschaft

  公开号：US04681882A1

  公开（公告）日：1987-07-21

  4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation. For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arteriosclerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.

  本文介绍了4-烷氧基-吡啶并[2,3-d]嘧啶衍生物及其制备过程。由于其血管痉挛作用，这些化合物主要适用于治疗脑、心脏和外周血管疾病，如心肌缺血、脑梗死、肺血栓以及动脉硬化和其他狭窄性疾病。因此，它们是对抗心血管疾病死亡率的有价值的药物。
• 4-oxo-pyrido[2,3-d]pyrimidinone derivatives
  申请人：Warner-Lambert Company

  公开号：US04677108A1

  公开（公告）日：1987-06-30

  4-Oxo-pyrido[2,3-d]pyrimidine derivatives are herein described as well as processes for their preparation. These compounds possess valuable pharmacological properties. As calcium antagonists they exert vasospasmolytic, vasodilatory, and antihypertensive activities. Surprisingly some of the compounds also have the effect of increasing contractility. They are therefore particularly suited for the treatment of vascular diseases.

  本文介绍了4-氧代吡啶[2,3-d]嘧啶衍生物及其制备过程。这些化合物具有有价值的药理特性。作为钙拮抗剂，它们具有解痉、扩张血管和降压的作用。令人惊讶的是，其中一些化合物还具有增加收缩力的作用。因此，它们特别适用于治疗血管疾病。
• Aminoalkylideamino-1,4-dihydropyridines and their use as medicaments
  申请人：Bayer Aktiengesellschaft

  公开号：US04146627A1

  公开（公告）日：1979-03-27

  The circulation provides new aminoalkylidene-amino-1,4-dihydropyridines which influence the circulatory system and are useful, for instance, as antihypertensive agents. Also included in the invention are methods for the preparation of said dihydropyridines, compositions containing them and methods for their use.

  这项发明提供了对循环系统有影响的新型氨基烷基亚胺基-1,4-二氢吡啶类化合物，例如作为降血压剂。该发明还包括制备上述二氢吡啶类化合物的方法，含有它们的组合物以及它们的使用方法。
• 2-Amino-3,4-dihydropyridines
  申请人：Bayer Aktiengesellschaft

  公开号：US04001252A1

  公开（公告）日：1977-01-04

  2-Amino-3,4-dihydropyridine-3-carboxylic acid ester derivatives are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid ester derivatives with an alkylating agent in the presence of an inert organic solvent at a temperature of from 20.degree. to 200.degree. C. and exhibit antihypertensive and coronary dilating properties.

  2-氨基-3,4-二氢吡啶-3-羧酸酯衍生物是通过将2-氨基-1,4-二氢吡啶-3-羧酸酯衍生物与烷基化剂在惰性有机溶剂存在下反应，在20℃至200℃的温度下制备的，具有降压和扩张冠状动脉的特性。
• 2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and
  申请人：Bayer Aktiengesellschaft

  公开号：US04002762A1

  公开（公告）日：1977-01-11

  3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an inert organic solvent at a temperature of from 20.degree. C to 200.degree. C. The compounds, of which 2-amino-3,6-dimethyl-4-phenyl-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is a typical embodiment, possess antihypertensive and coronary dilating properties.

  3-取代基2-氨基-3,4-二氢吡啶-3-羧酸酯通过在惰性有机溶剂存在下，将2-氨基-1,4-二氢吡啶-3-羧酸酯与烷基化剂反应，在20℃至200℃的温度下制备而成。其中，2-氨基-3,6-二甲基-4-苯基-3,4-二氢吡啶-3,5-二羧酸二乙酯是一种典型的化合物，具有降压和扩张冠状动脉的特性。