3-(Trifluoromethyl)phenyl butanoate | 331-34-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 3-(Trifluoromethyl)phenyl butanoate
• 英文别名: [3-(trifluoromethyl)phenyl] butanoate
• CAS: 331-34-0
• 化学式: C₁₁H₁₁F₃O₂
• 分子量: 232.2
• InChiKey: NVQBWKJQSIJKKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PROCESS OF PREPARING SUBSTITUTED PYRIMIDINONES
  申请人：Amgen Inc.

  公开号：EP1037881B1

  公开（公告）日：2003-11-12
• FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF
  申请人：Asahi Glass Company, Limited

  公开号：EP2338935B1

  公开（公告）日：2012-12-12
• FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS
  申请人：Nakano Takashi

  公开号：US20110172336A1

  公开（公告）日：2011-07-14

  To provide a composition comprising a fluorocopolymer such as an ethylene/tetrafluoroethylene copolymer which can be produced at a relatively low temperature, and its production process. A fluorocopolymer composition which comprises a fluorocopolymer such as an ethylene/tetrafluoroethylene copolymer and a fluorinated aromatic compound having a melting point of at most 230° C. and having a fluorine content in the compound of from 5 to 75 mass %, and is in a solution state at a temperature of at most the melting point of the fluorocopolymer, and a process for producing the fluorocopolymer composition, which comprises a step of dissolving the fluorocopolymer in a solvent containing the fluorinated aromatic compound at a temperature of at most the melting point of the fluorocopolymer.
• US8952083B2
  申请人：——

  公开号：US8952083B2

  公开（公告）日：2015-02-10
• [EN] PROCESS OF PREPARING SUBSTITUTED PYRIMIDINONES<br/>[FR] PROCEDE SERVANT A PREPARER DES PYRIMIDINONES SUBSTITUEES
  申请人：AMGEN, INC.

  公开号：WO1999028303A1

  公开（公告）日：1999-06-10

  (EN) The present invention relates to a process useful in the preparation of compounds which are useful in treating diseases, such as TNF-$g(a), IL-1$g(b), IL-6 and/or IL-8 mediated diseases and other maladies. In accordance with the present invention, there is provided a process for preparing compounds of formula (I) comprising (a) mixing R11-CH2-C(O)L and R12-CN in a suitable solvent and in the presence of base; and (b) adding R4-N=C=X; or comprising (a) mixing R11-CH2-C(O)L and R12-CN in a suitable solvent and in the present of base; (b) adding R4-N=C=X; and (c) adding R2-L'; wherein L, L', X, R2, R4, R11 and R12 are defined in the claims.(FR) L'invention concerne un procédé servant à préparer des composés utiles pour traiter des maladies, telles que des maladies provoquées par l'intermédiaire de TNF-$g(a), IL-1$g(b), IL-6 et/ou IL-8, ou d'autres maladies. Elle concerne un procédé servant à préparer des composés représentés par la formule I I et consistant (a) à mélanger R11-CH2-C(O)L et R12-CN dans un solvant approprié en présence d'une base et (b) à ajouter R4-N=C=X ou consistant (a) à mélanger R11-CH2-C(O)L et R12-CN dans un solvant approprié en présence d'une base et (b) à ajouter R2-L'; dans laquelle L, L', X, R2, R11 et R12 sont tels qu'ils sont définis dans les revendications.