methyl 2-hydroxy-3,5-dimethylbenzoate | 117369-92-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-hydroxy-3,5-dimethylbenzoate
• 英文别名: 2-hydroxy-3,5-dimethyl-benzoic acid methyl ester；2-Hydroxy-3,5-dimethyl-benzoesaeure-methylester
• CAS: 117369-92-3
• 化学式: C₁₀H₁₂O₃
• mdl: MFCD24393078
• 分子量: 180.203
• InChiKey: MDKRUWLGYSFHKW-UHFFFAOYSA-N

物化性质

• 沸点：
  262.0±35.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 2-hydroxy-3,5-dimethylbenzoate 在 羟胺 作用下， 生成 2-hydroxy-3,5-dimethyl-benzohydroxamic acid
  参考文献：
  名称：

  Urbanski, Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1953, vol. 1, p. 319,320

  摘要：

  DOI：
• 作为产物：
  描述：

  均三甲苯磺酸 在 盐酸 、 氢氧化钾 、 potassium carbonate 作用下， 生成 methyl 2-hydroxy-3,5-dimethylbenzoate
  参考文献：
  名称：

  Analysis of aqueous humour proteins of eyes with and without pseudoexfoliation syndrome

  摘要：

  Pseudoexfoliation syndrome (PEX) has been suggested to represent a blood-aqueous barrier impairment leading to a higher protein content in aqueous humour of eyes with PEX. However, the nature of a prospective PEX protein has not yet been described. We set out to reevaluate protein content and examine protein composition for prospective PEX protein candidates in aqueous humour of eyes with PEX syndrome. Aqueous humour of 52 patients with PEX and 38 without PEX signs was sampled during cataract or glaucoma surgery. Total aqueous protein concentration in the samples was analysed in 43 PEX specimens and 32 non-PEX specimens according to Bradford. Aqueous protein composition of all samples was determined by sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS PAGE) and silver staining. Screening for amyloids was performed in nine PEX samples and six non-PEX samples by Congo Red staining and polarised light microscopy. Aqueous protein concentration was not significantly increased in PEX eyes in comparison with non-PEX eyes. Furthermore, we could not detect any characteristic difference in protein band sizes of the two groups after SDS PAGE. However, we were able to show the presence of amyloid exclusively in aqueous humour of PEX patients. Conclusion: our results do not confirm a generally higher protein concentration in pseudoexfoliation syndrome eyes. This does not necessarily contradict a blood-aqueous barrier impairment but illustrates the variance in protein concentration between and within the two groups. No characteristic protein band allocatable to pseudoexfoliation syndrome proteins could be detected in any of the samples. However, our findings support the theory that the pseudoexfoliation syndrome is associated with an amyloid of a serum protein.

  DOI：

  10.1007/s004170100357

文献信息

• [EN] METHOD TO PREPARE PHENOLICS FROM BIOMASS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS PHÉNOLIQUES À PARTIR DE BIOMASSE
  申请人：TNO

  公开号：WO2016114668A1

  公开（公告）日：2016-07-21

  The present invention is directed to a method for preparing a final phenolic product from biomass comprising the steps of providing a furanic compound obtainable from biomass; reacting the furanic compound with a dienophile to obtain a phenolic compound; reacting the phenolic compound further to obtain the final phenolic product.

  本发明涉及一种从生物质制备最终酚类产品的方法，包括以下步骤：提供可以从生物质中获得的一种呋喃化合物；将呋喃化合物与二烯体反应以获得酚类化合物；进一步反应酚类化合物以获得最终酚类产品。
• An Efficient One-Pot Synthesis of Phenol Derivatives by Ring Opening and Rearrangement of Diels-Alder Cycloadducts of Substituted Furans Using Heterogeneous Catalysis and Microwave Irradiation
  作者：Andrés Moreno、Antonio de la Hoz、María Victoria Gómez、Ester Vázquez、Angel Díaz-Ortiz、Pilar Prieto、José Antonio Mayoral、Elisabet Pires

  DOI：10.1055/s-2004-825604

  日期：——

  under microwave irradiation promotes regiospecific opening of the 7-oxa bridge of Diels-Alder cycloadducts of furan derivatives and produces polysubstituted phenols in a single step. This rapid and efficient procedure permits the synthesis of tri-, tetra- and pentasubstituted benzene derivatives by reaction of 2,5-dimethylfuran (1), 2-ethylfuran (2) and 2-methoxyfuran (3) with dienophiles such as dimethyl

  在微波辐射下使用二氧化硅负载的路易斯酸作为催化剂促进了呋喃衍生物的 Diels-Alder 环加合物的 7-氧杂桥的区域特异性打开，并在一个步骤中产生多取代酚。这种快速有效的方法允许通过 2,5-二甲基呋喃 (1)、2-乙基呋喃 (2) 和 2-甲氧基呋喃 (3) 与亲二烯体（如乙炔二甲酸二甲酯和丙炔酸甲酯。
• Method to prepare phenolics from biomass
  申请人：Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO

  公开号：US10407376B2

  公开（公告）日：2019-09-10

  The present invention is directed to a method for preparing a final phenolic product from biomass comprising the steps of providing a furanic compound obtainable from biomass; reacting the furanic compound with a dienophile to obtain a phenolic compound; reacting the phenolic compound further to obtain the final phenolic product.

  本发明涉及一种从生物质中制备最终酚类产品的方法，该方法包括以下步骤：提供一种可从生物质中获得的呋喃化合物；使呋喃化合物与一种亲二烯化合物反应以获得一种酚类化合物；使酚类化合物进一步反应以获得最终酚类产品。
• Manganese(III)-based oxidative free-radical cyclizations. Oxidative cyclization and aromatization of 3-oxo-6-heptenoate esters
  作者：Barry B . Snider、Jeffrey J. Patricia

  DOI：10.1021/jo00262a016

  日期：1989.1
• The Effect of Changes in the Allyl Group on the Rearrangement of Allyl Ethers of Salicylic Acids
  作者：William R. Nummy、D. Stanley Tarbell

  DOI：10.1021/ja01148a026

  日期：1951.4