4-(4-Chlor-phenyl)-but-3-ensaeure | 90797-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-Chlor-phenyl)-but-3-ensaeure
• 英文别名: 4-(4-chloro-phenyl)-but-3-enoic acid；γ-(4-Chlor-phenyl)-vinylessigsaeure；β-(4-Chlor-benzal)-propionsaeure；4-(4-Chlorophenyl)but-3-enoic acid
• CAS: 90797-93-6
• 化学式: C₁₀H₉ClO₂
• 分子量: 196.633
• InChiKey: BKRAWOAKGFMKKB-UHFFFAOYSA-N

物化性质

• 沸点：
  358.4±22.0 °C(Predicted)
• 密度：
  1.281±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-Chlor-phenyl)-but-3-ensaeure 生成 7-氯萘-1-醇
  参考文献：
  名称：

  Erdmann; Schwechten, Justus Liebigs Annalen der Chemie, 1890, vol. 260, p. 74,75

  摘要：

  DOI：
• 作为产物：
  描述：

  trans-4-(4-chlorophenyl)-3-butenoic acid ethyl ester 在 alkali 作用下， 生成 4-(4-Chlor-phenyl)-but-3-ensaeure
  参考文献：
  名称：

  713. 2：6-二氨基-3-芳基吡啶的合成

  摘要：

  DOI：

  10.1039/jr9530003548

文献信息

• Synthesis of Allylboranes via Cu(I)-Catalyzed B–H Insertion of Vinyldiazoacetates into Phosphine–Borane Adducts
  作者：Denis Drikermann、Robert S. Mößel、Walid K. Al-Jammal、Ivan Vilotijevic

  DOI：10.1021/acs.orglett.9b04619

  日期：2020.2.7

  Cu(I) catalysts enable C-B bond formation via direct insertion of vinyldiazoacetates into B-H bonds of borane-phosphine Lewis adducts to form phosphine-protected allylboranes under mild conditions. The resulting allylborane-phosphine Lewis adducts can be used in the diastereoselective allylation of aldehydes directly without the need for removal of the phosphine. The allylation reaction proceeds with

  Cu（I）催化剂可通过将重氮乙酸乙烯酯直接插入硼烷-膦路易斯加合物的BH键中而形成CB键，从而在温和条件下形成膦保护的烯丙基硼烷。所得的烯丙基硼烷-膦路易斯路易斯加合物可直接用于醛的非对映选择性烯丙基化，而无需除去膦。烯丙基化反应以高非对映选择性进行，并在用适当的酸处理后产生5，6-二取代的二氢吡喃酮。
• Mn(OAc)₃-mediated phosphonation–lactonization of alkenoic acids: synthesis of phosphono-γ-butyrolactones
  作者：Yuzhen Gao、Xueqin Li、Jian Xu、Yile Wu、Weizhu Chen、Guo Tang、Yufen Zhao

  DOI：10.1039/c4cc07978g

  日期：——

  A new, general method for the synthesis of phosphono-γ-butyrolactones has been achieved through Mn(OAc)₃-mediated radical oxidative phosphonation and lactonization of alkenoic acids withH-phosphonates andH-phosphine oxide.

  通过Mn(OAc)₃介导的自由基氧化磷化和内酯化合成磷酸γ-丁酯的一种新的通用方法已经实现，该方法利用烯酸与H-磷酸酯和H-膦氧化物进行反应。
• Enantioselective Epoxidation of β,γ-Unsaturated Carboxylic Acids by a Cooperative Binuclear Titanium Complex
  作者：Takahiro Sawano、Hisashi Yamamoto

  DOI：10.1021/acscatal.9b00840

  日期：2019.4.5

  Enantioselective epoxidation of β,γ-unsaturated carboxylic acids with a cooperative binuclear titanium complex has been developed to provide single diastereomer γ-lactones in high yields and enantioselectivities via intramolecular cyclization. For the success of the reaction, the proper distance between the carboxylic acid and alkene is quite important, offering the regioselective epoxidation of unsaturated

  已经开发了具有合作双核钛配合物的β，γ-不饱和羧酸的对映选择性环氧化，可通过分子内环化以高收率和对映选择性提供单一的非对映异构体γ-内酯。为了使反应成功，羧酸和链烯烃之间的适当距离非常重要，它可以使带有两个相似链烯的不饱和羧酸进行区域选择性环氧化。
• Butenoic or propenoic acid derivatives
  申请人：Eisai Co., Ltd.

  公开号：EP0344577A2

  公开（公告）日：1989-12-06

  A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phenyl having substituents and a heterocyclic ring may be formed between R2, R3 and J is provided here and is useful in the pharmacological field.

  丁烯酸或丙烯酸衍生物具有下式，其中 G 为芳基或杂环，R11 和 R12 为氢基或烷基，X 为硫或氧，R2 和 R3 为氢，取代基如烷基，J 为吡啶基或苯基，R2、R3 和 J 之间可形成杂环，该衍生物在药理学领域非常有用。
• Cyclosulfenylation of <i>N</i>-(1(2)-naphthyl) styrylacetamides as a synthetic route to 4(2)-arylthio naphtho[1,2-<i>b</i>]([2,1-<i>b</i>])azepin-2(4)-ones
  作者：Ivanna Yu. Danyliuk、Alla I. Vaskevych、Ruslan I. Vaskevych、Eduard B. Rusanov、Mykhailo V. Vovk

  DOI：10.1080/17415993.2020.1855431

  日期：2021.5.4

  Cyclofunctionalization of 1- and 2-naphthyl styrylacetamides with benzene- and 4-toluenesulfenyl chlorides in a nitromethane medium in the presence of an equimolar amount of LiClO4 as a doping agent is distinguished by high chemoselectivity affording, respectively, 5-aryl-4-arylthio-1,3,4,5-tetrahydro-2H-naphtho[1,2-b]azepin-2-ones and 1-aryl-2-arylthio-1,2,3,5-tetrahydro-4H-naphtho[2,1-b]azepin-4-ones.