5-(p-tolyl)-2,2'-bithiophene | 106925-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: 5-(p-tolyl)-2,2'-bithiophene
• 英文别名: 2-(4-Methylphenyl)-5-thiophen-2-ylthiophene
• CAS: 106925-77-3
• 化学式: C₁₅H₁₂S₂
• 分子量: 256.392
• InChiKey: KTFXDMAAZPMIKB-UHFFFAOYSA-N

物化性质

• 熔点：
  129.5-131 °C
• 沸点：
  375.4±32.0 °C(Predicted)
• 密度：
  1.191±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(p-tolylbuta-1,3-diyn-1-yl)thiophene 在 copper(l) iodide 、 sodiumsulfide nonahydrate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以78%的产率得到5-(p-tolyl)-2,2'-bithiophene
  参考文献：
  名称：

  在配体和无Pd / Ni的铜催化下快速进入不对称的1,3-二炔和2,5-二取代的噻吩†

  摘要：

  实现了无Pd / Ni的铜催化串联合成，可快速从1,1-二溴烯烃和末端炔烃中获得不对称的1,3-二炔。该方法扩展到一锅操作中不对称2,5-二取代噻吩的直接合成。

  DOI：

  10.1039/c5ra15705f

文献信息

• Direct C–H Arylation of Thiophenes at Low Catalyst Loading of a Phosphine-Free Bis(alkoxo)palladium Complex
  作者：Yabo Li、Jingran Wang、Mengmeng Huang、Zhiwei Wang、Yusheng Wu、Yangjie Wu

  DOI：10.1021/jo402745b

  日期：2014.4.4

  An efficient phosphine-free direct C–H arylation of thiophenes at the α-position has been developed at low catalyst loading of bis(alkoxo)palladium complex (Cat.I, 0.1–0.2 mol %). The developed synthetic method can be applied to the synthesis of α-aryl/heteroaryl thiophenes from aryl or heteroaryl bromides in good to excellent yields and is compatible with the substrates bearing electron-donating or

  在双（烷氧基）钯配合物（Cat.I，0.1-0.2 mol％）的低催化剂负载下，已开发出一种有效的无磷的噻吩在α位上无膦直接CH芳基化的化合物。所开发的合成方法可用于从芳基或杂芳基溴化物以良好至优异的产率合成α-芳基/杂芳基噻吩，并且与带有给电子或吸电子基团的底物相容。噻吩2位和5位的反应性是相同的，并且在最佳条件下不依赖于空间位阻。该条件还可以以高转化率应用于其他杂环部分，例如苯并噻吩，苯并呋喃和吡咯。
• NOVEL FLUORENE COMPOUND
  申请人：HIROSE Hidekazu

  公开号：US20100197942A1

  公开（公告）日：2010-08-05

  A fluorene compound is provided, which is represented by the following Formula (I): in Formula (1), R 11 and R 12 each independently represent an alkyl group having 1 to 6 carbon atoms; R 21 and R 22 each independently represent an alkyl group having 1 to 8 carbon atoms, or an alkoxy group having 1 to 8 carbon atoms; and n1 and n2 each independently represent an integer of from 1 to 5.

  提供一种萘化合物，其由以下化学式（I）表示： 在化学式（1）中，R11和R12分别独立表示具有1至6个碳原子的烷基基团；R21和R22分别独立表示具有1至8个碳原子的烷基基团，或具有1至8个碳原子的烷氧基团；n1和n2分别独立表示从1到5的整数。
• SUBSTITUTED AZOLES, ANTIVIRAL ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARATION AND USE THEREOF
  申请人：Ivachtchenko Alexandre Vasilievich

  公开号：US20130253008A1

  公开（公告）日：2013-09-26

  The present invention relates to novel azoles, novel antiviral active components of the general formulas 1A and 1B, pharmaceutical composition, antiviral medicament, method for prophylaxis and treatment of viral diseases, particularly caused by hepatitis C viruses (HCV). In general formulas 1A and 1B wherein: solid lines with accompanying dotted lines ( ) represent ordinary bond or double bond, provided that one of them is an ordinary bond, the other one is double bond; X and Y accept various meanings, one of them is—nitrogen, the other—oxygen, sulfur or NH group; R 1 and R 2 —optionally the same radicals selected from 2-(R)- and (S)-substituted N-acyl pyrrolidine derivatives; N-methyl-N-[2-(R) and (S)-substituted 2,2-disubstituted acetamides; methyl[2-(R) and (S)-substituted ((methyl)amino)-(1-oxobutan-2-yl)-2-(R)-] and (S)-iso-propyl)-carbamates. A represents aliphatic C 2 -C 8 biradical; dioxane, cyclo- and bicycloaliphatic, alkyloxyalkyl, alkyloxyalkylenoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl biradicals and their thioanaloges; aryl and thiophene alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, alkyloxyaryl, alkenyloxyaryl, alkynyloxyaryl, alkylthioaryl, alkenylthioaryl, alkynylthioaryl, cycloalkylthiophene, aryldioxane and thiophenyldioxane biradicals. B represents: aliphatic C 2 -C 8 radical, including 1, 2 or 3 triple C≡C bonds; aryl and thiophene, alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, cycloalkylbenzene, 4-cycloalkylbiphenyl, bicycloalkylbenzene, 4-bicycloalkylbiphenyl, cycloalkylthiophene, aryldioxane and thiophenyldioxane radicals.

  本发明涉及新型唑类化合物，通式1A和1B的新型抗病毒活性成分，药物组合物，抗病毒药物，预防和治疗病毒性疾病的方法，特别是由丙型肝炎病毒（HCV）引起的疾病。在通式1A和1B中，其中：实线与伴随虚线（）表示普通键或双键，前提是其中一个是普通键，另一个是双键；X和Y接受各种含义，其中一个是氮，另一个是氧、硫或NH基团；R1和R2—可选地选择自2-(R)-和(S)-取代的N-酰基吡咯烷衍生物；N-甲基-N-[2-(R)和(S)-取代的2,2-二取代乙酰胺；甲基[2-(R)和(S)-取代的((甲基)氨基)-(1-氧代丁酰)-2-(R)-]和(S)-异丙基)-氨基甲酸酯。A代表脂肪族C2-C8双基；二氧六环、环和双环脂肪族、烷氧烷基、烷氧烷氧基烷基、烯烃氧烷基、炔烃氧烷基双基及其硫代物；芳基和噻吩炔基环烷基、炔基二氧六环、炔基芳基、烷基噻吩烯烯基、炔基噻吩、烷氧芳基、烯烃氧芳基、炔烃氧芳基、烷硫芳基、烯硫芳基、炔硫芳基、环烷基噻吩、芳基二氧六环和噻吩二氧六环双基。B代表：脂肪族C2-C8基，包括1、2或3个三重键C≡C键；芳基和噻吩、炔基环烷基、炔基二氧六环、炔基芳基、烷基噻吩、烯烃噻吩和炔基噻吩、环烷基苯、4-环烷基联苯、双环烷基苯、4-双环烷基联苯、环烷基噻吩、芳基二氧六环和噻吩二氧六环基。
• Arylamine compound, charge transport material, electrophotographic photoreceptor, image forming apparatus, and process cartridge
  申请人：Iwasaki Masahiro

  公开号：US20070148571A1

  公开（公告）日：2007-06-28

  An arylamine compound represented by formula (I). Ar 1 represents a phenyl group substituted by a substituted or unsubstituted monovalent polycyclic aromatic hydrocarbon group, and a substituted or unsubstituted monovalent heterocyclic group. Ar 2 represents a substituted or unsubstituted arylene group. R 1 represents a hydrogen atom, a halogen atom, an alkoxy group, or a substituted or unsubstituted alkyl group. R 2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group. R 3 and R 4 each independently represents a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group, at least one of R 3 and R 4 represents a substituted or unsubstituted aryl group, and R 3 and R 4 may be bound to form a ring via a single bond or a divalent group m represents an integral of from 0 to 4.

  由公式(I)表示的芳胺化合物。Ar1代表一个被取代或未取代的多环芳香烃基团和一个取代或未取代的杂环基团取代的苯基团，Ar2代表一个取代或未取代的芳基团。R1代表氢原子、卤素原子、烷氧基或取代或未取代的烷基团。R2代表氢原子、取代或未取代的烷基团或取代或未取代的芳基团。R3和R4各自独立地代表氢原子、取代或未取代的烷基团或取代或未取代的芳基团，R3和R4中至少一个代表取代或未取代的芳基团，R3和R4可以通过单键或双价基团结合形成环。m的值为0到4的整数。
• QUINOXALINE-CONTAINING COMPOUNDS AND POLYMERS THEREOF
  申请人：HORIBA Koji

  公开号：US20080306239A1

  公开（公告）日：2008-12-11

  There is provided a quinoxaline-containing compound represented by the following formula (I); wherein Ar 1 represents a substituted or unsubstituted monovalent aromatic group; and R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group.

  提供一种含有喹啉基的化合物，其化学式如下（I）；其中Ar1代表一个取代或未取代的一价芳香基团；而R1代表氢原子、取代或未取代的烷基团、取代或未取代的芳基团，或取代或未取代的芳基烷基团。