5-acetyl-2-(4-methylphenyl)benzofuran | 1374787-33-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 5-acetyl-2-(4-methylphenyl)benzofuran
• 英文别名: 1-[2-(4-Methylphenyl)-1-benzofuran-5-yl]ethanone；1-[2-(4-methylphenyl)-1-benzofuran-5-yl]ethanone
• CAS: 1374787-33-3
• 化学式: C₁₇H₁₄O₂
• 分子量: 250.297
• InChiKey: WRRFDKOAEOWZTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-乙酰基-2-溴苯并呋喃 、 三对甲苯基铋 在 palladium diacetate 、 caesium carbonate 、 三苯基膦 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 1.0h， 以88%的产率得到5-acetyl-2-(4-methylphenyl)benzofuran
  参考文献：
  名称：

  Palladium-catalyzed cross-couplings of functionalized 2-bromobenzofurans for atom-economic synthesis of 2-arylbenzofurans using triarylbismuth reagents

  摘要：

  The palladium catalyzed, atom-economic synthesis of various functionalized 2-arylbenzofurans was achieved through cross-coupling reaction of 2-bromobenzofurans with triarylbismuth reagents. The palladium catalytic protocol is very efficient to furnish various cross-coupled functionalized 2-arylbenzofurnas in high yields using triarylbismuth reagents with three aryl couplings as multi-coupling organometallic nucleophiles in one-pot operation. All the coupling reactions were completed in 1 h short reaction time involving three couplings from triarylbismuths under heating condition. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.059