1-(1-Naphthalenylmethoxy)naphthalene | 135505-58-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(1-Naphthalenylmethoxy)naphthalene
• 英文别名: 1-(naphthalen-1-ylmethoxy)naphthalene
• CAS: 135505-58-7
• 化学式: C₂₁H₁₆O
• 分子量: 284.357
• InChiKey: WIVHAXJTXQMLCL-UHFFFAOYSA-N

物化性质

• 沸点：
  477.5±14.0 °C(Predicted)
• 密度：
  1.173±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(1-Naphthalenylmethoxy)naphthalene 在 sodium 、 N,N-二甲基甲酰胺 作用下， 反应 0.33h， 生成 二-1-萘甲醇
  参考文献：
  名称：

  Novel synthesis of N,N-diarylarylmethanamines from N-(arylmethylene)arenamines and (arylmethoxy)arenes

  摘要：

  Various N,N-diarylarylmethanamines were synthesized by the reaction of N-(arylmethylene)arenamines with (arylmethoxy)arenes in dimethylformamide solution in the presence of a strong base as a catalyst which is obtained in situ by reacting metallic sodium with this solvent. In general, the reaction may be depicted as the reduction of the imine and addition, on the original imino nitrogen atom, of the aryl group (of the aryloxy moiety) of the ether and presumably oxidation of the arylmethoxy group of the either to its corresponding aldehyde. Side reactions and a proposed reaction mechanism are discussed.

  DOI：

  10.1021/jo00020a032
• 作为产物：
  描述：

  萘酚 、 (氯甲基)萘 在 氢氧化钾 作用下， 生成 1-(1-Naphthalenylmethoxy)naphthalene
  参考文献：
  名称：

  Novel synthesis of N,N-diarylarylmethanamines from N-(arylmethylene)arenamines and (arylmethoxy)arenes

  摘要：

  Various N,N-diarylarylmethanamines were synthesized by the reaction of N-(arylmethylene)arenamines with (arylmethoxy)arenes in dimethylformamide solution in the presence of a strong base as a catalyst which is obtained in situ by reacting metallic sodium with this solvent. In general, the reaction may be depicted as the reduction of the imine and addition, on the original imino nitrogen atom, of the aryl group (of the aryloxy moiety) of the ether and presumably oxidation of the arylmethoxy group of the either to its corresponding aldehyde. Side reactions and a proposed reaction mechanism are discussed.

  DOI：

  10.1021/jo00020a032

文献信息

• PHARMACEUTICAL COMPOSITIONS OF 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-3,4-DIHYDROPYRAZINO [2,3-B]PYRAZIN-2(1H)-ONE, A SOLID FORM THEREOF AND METHODS OF THEIR USE
  申请人：Signal Pharmaceuticals, LLC

  公开号：US20140356430A1

  公开（公告）日：2014-12-04

  Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.

  本文提供了7-(6-(2-羟基丙烷-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3,4-二氢吡嗪并[2,3-b]吡嗪-2(1H)-酮的组合物，固体形式，同位素和代谢物，以及它们用于治疗疾病，紊乱或状况的方法。
• Regioselective rearrangement reactions of naphthyl naphthylmethyl ethers by using Lewis acids or UV light irradiation
  作者：Hajime Maeda、Saki Nakamura、Taniyuki Furuyama、Masahito Segi

  DOI：10.1016/j.molstruc.2022.134450

  日期：2023.2

  Et2AlCl) in CH2Cl2 produced rearranged products of the naphthylmethyl group to the 2- and 7-positions of the naphthalene, whereas rearrangement of 2-naphthyl ethers 3 and 4 proceeded to the 1-position. When benzene solution of compound 1 was irradiated, rearrangement to the 4-position proceeded, whereas rearrangement of 2 proceeded to the 2- and 4-positions. Photoinduced rearrangement of 3 and 4 proceeded

  1-萘基萘甲基醚1和2与路易斯酸（BF 3 -Et 2 O 或 Et 2 AlCl）在 CH 2 Cl 2中的反应产生萘甲基重排到萘的 2 位和 7 位的产物，而2-萘基醚3和4的重排进行到 1 位。当化合物1的苯溶液被辐照时，重排到4位进行，而2的重排进行到2位和4位。3和4的光致重排如在使用路易斯酸的反应中进行到1-位。在与路易斯酸的反应中，离子对由路易斯酸配位的萘氧基阴离子和萘甲基阳离子组成，在光反应中，CO键均裂产生的自由基对被认为是中间体。对中间体负电荷分布和自旋密度的计算表明，反应的区域选择性可以通过每个片段的电荷密度和自旋密度、空间位阻和溶剂笼效应来解释。
• CURABLE RESIN COMPOSITION, CURED PRODUCT THEREOF, PHENOLIC RESIN, EPOXY RESIN, AND SEMICONDUCTOR SEALING MATERIAL
  申请人：Ogura Ichirou

  公开号：US20130237639A1

  公开（公告）日：2013-09-12

  A high degree of resistance to moisture and solder and high flame retardancy are realized without incorporating a halogen in view of environmental friendliness. A phenolic resin has structural moieties which are a naphthylmethyloxy group- or anthrylmethyloxy group-containing aromatic hydrocarbon group (ph1), a phenolic hydroxyl group-containing aromatic hydrocarbon group (ph2), and a divalent aralkyl group (X) represented by general formula (1) below: (where Ar represents a phenylene group or a biphenylene group and Rs each independently represent a hydrogen atom or a methyl group) and has a structure in which plural aromatic hydrocarbon groups selected from the group consisting of the naphthylmethyloxy group- or anthrylmethyloxy group-containing aromatic hydrocarbon group (ph1) and the phenolic hydroxyl group-containing aromatic hydrocarbon group (ph2) are bonded through the divalent aralkyl group (X). This phenolic resin is used as a curing agent for an epoxy resin.
• US5011998A
  申请人：——

  公开号：US5011998A

  公开（公告）日：1991-04-30
• US5117062A
  申请人：——

  公开号：US5117062A

  公开（公告）日：1992-05-26